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公开(公告)号：US09988654B2
公开(公告)日：2018-06-05
申请号：US14740749
申请日：2015-06-16
IPC分类号： C12P7/62 , C12P7/44 , C12P13/00 , C12P7/42 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C12N9/18 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
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公开(公告)号：US09988653B2
公开(公告)日：2018-06-05
申请号：US14975584
申请日：2015-12-18
申请人： California Institute of Technology , University of Southern California , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： Adam Vinay Subhas , William Berelson , Nick Everett Rollins , Jess Firey Adkins , Jonathan Erez
CPC分类号： C12P7/40 , B01D53/346 , B01D53/62 , B01D53/77 , B01D53/8671 , B01D2251/606 , B01D2251/90 , B01D2255/804 , C12M23/58 , C12M27/00 , C12M29/00 , C12M29/04 , C12M29/18 , Y02C10/04 , Y02P20/152 , Y02P20/59
摘要： Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO2 in proximity with a sequestration agent are provided. Reactants are combined with catalyst such that at least two regions of controlled catalytic activity form encompassing at least the interface between a sequestration agent and an aqueous solution containing dissolved CO2. Suitable reactants include various sequestration agents, catalyst, and carbon dioxide dissolved in an aqueous solution (seawater, for example). Possible products include bicarbonate and metal cations.
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公开(公告)号：US09963730B2
公开(公告)日：2018-05-08
申请号：US15596658
申请日：2017-05-16
申请人： XYLECO, INC.
IPC分类号： C12P19/14 , C12P7/10 , C12N9/42 , C12P5/02 , C12P7/04 , C12P7/16 , C12P7/24 , C12P7/28 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/52 , C12P7/56 , C12P7/62 , C12P19/02 , C12P19/04 , C12P19/12
CPC分类号： C12P19/14 , C12N9/2434 , C12N9/2437 , C12P5/02 , C12P5/023 , C12P7/04 , C12P7/10 , C12P7/16 , C12P7/24 , C12P7/28 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/52 , C12P7/56 , C12P7/62 , C12P19/02 , C12P19/04 , C12P19/12 , C12P2201/00 , C12Y302/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： Provided herein are methods for processing biomass materials that are disposed in one or more structures or carriers, e.g., a bag, a shell, a net, a membrane, a mesh or any combination of these. Containing the material in this manner allows it to be readily added or removed at any point and in any sequence during processing.
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24.发明授权公开(公告)号：US09951362B2
公开(公告)日：2018-04-24
申请号：US15619377
申请日：2017-06-09
申请人： Inbiose N.V.
发明人： Joeri Beauprez , Gaspard Lequeux , Jo Maertens
摘要： The present invention relates to mutated and/or transformed microorganisms for the synthesis of various compounds. More specifically, the present invention discloses microorganisms mutated in the genes encoding for the regulators ArcA and IclR. The latter mutations result in a significant upregulation of the genes that are part of the colanic acid operon. Hence, said microorganisms are useful for the synthesis of any compound being part of the colanic acid pathway such as GDP-fucose, GDP-mannose and colanic acid, and/or, can be further used—starting form GDP-fucose as a precursor—to synthesize fucosylated oligosaccharides or—starting from GDP-mannose as a precursor—to synthesize mannosylated oligosaccharides. In addition, mutations in the genes coding for the transcriptional regulators ArcA and IclR lead to an acid resistance phenotype in the exponential growth phase allowing the synthesis of pH sensitive molecules or organic acids.
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公开(公告)号：US09944956B2
公开(公告)日：2018-04-17
申请号：US14412320
申请日：2013-07-05
发明人： Simon Curvers , Vitaly Svetlitchnyi
IPC分类号： C12P7/56 , C12P39/00 , C12N1/20 , C12N1/22 , C12P7/06 , C12P7/10 , C12P7/14 , C12P7/40 , C12R1/01
CPC分类号： C12P7/56 , C12N1/20 , C12N1/22 , C12P7/065 , C12P7/10 , C12P7/14 , C12P7/40 , C12P39/00 , C12P2201/00 , C12R1/01 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present technology pertains to methods and microbial co-cultures for converting lignocellulosic biomass to biofuels and/or other carbon-based chemicals. Aspects of the present disclosure relate to novel consolidated bioprocessing (CBP) methods by which the efficiency of the production of biofuels and/or other carbon-based chemicals from cellulosic biomass-containing materials can be increased. In particular, the present disclosure provides numerous microbiological co-cultures for increasing the efficiency of ethanol and/or lactic acid production from biomass.
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公开(公告)号：US09938542B2
公开(公告)日：2018-04-10
申请号：US15055045
申请日：2016-02-26
申请人： White Dog Labs, Inc.
IPC分类号： C12P7/56 , C12P7/54 , C12P7/52 , C12P7/26 , C12P7/28 , C12P7/16 , C12P7/06 , C12N1/20 , C12P7/04 , C12P7/24 , C12P7/18 , C12P7/40
CPC分类号： C12P7/28 , C12P7/04 , C12P7/06 , C12P7/065 , C12P7/16 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/54 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要： Mixotrophic fermentation method performed to make one or more bioproducts such as alcohols, organic acids of less than 7 carbons, acetone, 2,3-butanediol and mixtures thereof with a microorganism. The mixotrophic fermentation method includes providing an isolated organism and providing a first feedstock and a second feedstock for use in a fermentation medium. The first feedstock includes a carbon source that is metabolized by the native form of the organism at a rate of less than 0.01 g/hr/g cell mass, and the second feedstock includes CO, CO2, carbonate, bicarbonate, H2, glycerol, methanol, formate, urea or mixtures thereof. The mixotrophic fermentation method also includes culturing the organism in the fermentation medium, whereby both feedstocks are metabolized and a fermentation broth is formed, the broth having at least one bioproduct. Optionally, the bioproduct may be separated from the broth.
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公开(公告)号：US09920335B2
公开(公告)日：2018-03-20
申请号：US15387391
申请日：2016-12-21
申请人： XYLECO, INC.
IPC分类号： C12P7/10 , C12P7/62 , C12P7/40 , C12P7/14 , C12P7/06 , C12P7/04 , C12P7/54 , C12P7/56 , C13K1/02 , C13K1/06 , C12P7/46
CPC分类号： C12P7/10 , C10J2300/1612 , C10J2300/1665 , C10J2300/1681 , C12P7/04 , C12P7/065 , C12P7/14 , C12P7/40 , C12P7/46 , C12P7/54 , C12P7/56 , C12P7/62 , C13K1/02 , C13K1/06 , Y02E50/17 , Y02T50/678
摘要： Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels, carboxylic acids and equivalents thereof (e.g., esters and salts). For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol, butanol or organic acids (e.g., acetic or lactic acid), salts of organic acids or mixtures thereof. If desired, organic acids can be converted into alcohols, such as by first converting the acid, salt or mixtures of the acid and its salt to an ester, and then hydrogenating the formed ester. Acetogens or homoacetogens which are capable of utilizing a syngas from a thermochemical conversion of coal or biomass can be utilized to produce the desired product.
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公开(公告)号：US09902980B2
公开(公告)日：2018-02-27
申请号：US14354354
申请日：2012-10-30
CPC分类号： C12P7/40 , C12N9/0006 , C12N9/0051 , C12N15/52 , C12N15/70 , C12P5/00 , C12P7/00 , C12P7/16 , C12Y101/05006 , C12Y108/05004 , Y02E50/10
摘要： The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
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29.发明申请公开(公告)号：US20180023088A1
公开(公告)日：2018-01-25
申请号：US15659521
申请日：2017-07-25
CPC分类号： C12N15/52 , C08G69/08 , C12N9/0006 , C12N9/16 , C12N9/93 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P13/00 , C12P13/005 , C12Y101/01001 , C12Y101/01284 , C12Y301/02012 , C12Y603/04003
摘要： This disclosure describes methods for regulating the biosynthesis of pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, 7-aminoheptanol, or 1,7-heptanediol by channeling increased flux through the biosynthesis pathway to obtain an intermediate required for growth of the host microorganism.
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公开(公告)号：US09873836B2
公开(公告)日：2018-01-23
申请号：US14285158
申请日：2014-05-22
申请人： Virent, Inc.
发明人： Paul Blommel , Andrew Held , Ralph Goodwin , Randy Cortright
CPC分类号： C10G1/002 , C10G1/00 , C10G3/42 , C10G3/49 , C10G2300/1011 , C10G2300/1025 , C10G2400/30 , C12F3/02 , C12P5/005 , C12P7/02 , C12P7/10 , C12P7/40 , Y02E50/16 , Y02P30/20
摘要： The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting biomass to hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product.
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