公开(公告)号：US4892409A

公开(公告)日：1990-01-09

申请号：US218874

申请日：1988-07-14

Applicant: Harry F. Smith

Inventor： Harry F. Smith

IPC: G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/065

Abstract: The invention relates to photometric apparatus and method for determining a characteristic of individual ones of a plurality of samples contained within a plurality of sample chambers. The photometric apparatus includes an enclosure; a substantially uniform source of radiation coupled to the enclosure such that a plurality of sample chambers, disposed within the enclosure, are simultaneously illuminated by the uniform source; and apparatus for detecting an amount of radiation which is transmitted through individual ones of the sample chambers, the detecting apparatus having an output signal having a magnitude which is a function of the amount of radiation which is transmitted through an individual one of the sample chambers. The substantially uniform source of radiation may include at least one source of radiation having an output comprising wavelengths within a first range of wavelengths and an optically integrating sphere having a radiation input port coupled to the output of the source of radiation and a radiation output port coupled to the enclosure. The photometric apparatus may further include radiation directing devices interposed between the radiation output port and the plurality of sample chambers for simultaneously directing radiation emanating from the output port into each of the sample chambers. The directed radiation may be either focussed or collimated.

Abstract translation: 本发明涉及用于确定包含在多个样品室内的多个样品中的各个样品的特性的光度测定装置和方法。 测光装置包括外壳; 耦合到外壳的基本上均匀的辐射源，使得设置在外壳内的多个样品室同时被均匀光源照射; 以及用于检测通过单个样本室传输的辐射量的装置，该检测装置具有输出信号，该输出信号的幅度是通过单独一个样本室传输的辐射量的函数。 基本上均匀的辐射源可以包括至少一个辐射源，其具有包括在第一波长范围内的波长的输出和具有耦合到辐射源的输出的辐射输入端口的光学积分球，以及辐射输出端口 到外壳。 测光装置还可以包括插入在辐射输出端口和多个样品室之间的辐射导向装置，用于同时将从输出端口发出的辐射引导到每个样品室中。 定向辐射可以是聚焦的或准直的。

公开(公告)号：US4626684A

公开(公告)日：1986-12-02

申请号：US513307

申请日：1983-07-13

Applicant: Isaac J. Landa

Inventor： Isaac J. Landa

IPC: G01J3/18 ,  G01J3/44 ,  G01N21/64 ,  G01T1/00

CPC classification number: G01N21/6452 ,  G01J3/1833 ,  G01J3/4406 ,  G01N2021/6421 ,  G01N2021/6476 ,  G01N2201/0446

Abstract: An apparatus uses a rapid and efficient method for conducting fluorescence measurements, such as immuno assay, of a plurality of samples of a substance using pulsed or continuous light energy, front-end fluorescent optics, a mechanism which allows for lateral and tranverse scanning of rows and columns of wells, and spectra emission analysis of the spectra from the excited samples.

Abstract translation: 一种装置使用快速和有效的方法进行使用脉冲或连续光能的物质的多个样品的荧光测量，例如免疫测定，前端荧光光学器件，允许横向扫描和横向扫描行的机构 和列的列，以及来自激发样品的光谱的光谱发射分析。

公开(公告)号：US20240272077A1

公开(公告)日：2024-08-15

申请号：US18629280

申请日：2024-04-08

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Lauren Dell ZARZAR ,  Sara N. NAGELBERG ,  Mathias KOLLE ,  Amy GOODLING

IPC: G01N21/64 ,  B29D11/00

CPC classification number: G01N21/6452 ,  B29D11/00298 ,  G01N2201/0446

Abstract: The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.

公开(公告)号：US20230175967A1

公开(公告)日：2023-06-08

申请号：US17885167

申请日：2022-08-10

Applicant: Biogen MA Inc.

Inventor： JUSTIN MORETTO ,  Brandon Berry ,  Alex Doane

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

公开(公告)号：US20170363545A1

公开(公告)日：2017-12-21

申请号：US15671422

申请日：2017-08-08

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, JR. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/75 ,  B29C59/04 ,  G01N21/25 ,  G01N21/31 ,  G01N21/55 ,  B01L3/00 ,  G01N21/03 ,  G01N21/64 ,  B29C59/02 ,  B29C59/08 ,  B29C35/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

公开(公告)号：US20170299854A1

公开(公告)日：2017-10-19

申请号：US15636494

申请日：2017-06-28

Applicant: California Institute of Technology

Inventor： Jinho Kim ,  Changhuei Yang

IPC: G02B21/36 ,  G02B21/16 ,  G01N21/64 ,  H04N5/225 ,  G02B21/00

CPC classification number: G02B21/365 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0446 ,  G02B13/0095 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/367 ,  H04N5/22541 ,  H04N5/2256 ,  H04N5/2258

Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.

公开(公告)号：US09360469B1

公开(公告)日：2016-06-07

申请号：US15041589

申请日：2016-02-11

Applicant: Axion BioSystems, Inc.

Inventor： Isaac Perry Clements ,  Amanda Jervis Preyer ,  Swaminathan Rajaraman ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N21/01 ,  G01N33/483

CPC classification number: G01N33/4836 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/01 ,  G01N21/75 ,  G01N2021/015 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/062

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 所述系统还包括邻近所述多个孔中的相应一个孔设置的至少一个电极组，其中所述电极组包括至少一个电极，所述至少一个电极被配置为收集与相应的阱的至少一部分相关联的电信号。 该系统还包括对应于相应的一个孔的发光元件组，并且被配置为将光学刺激传送到相应孔的至少一部分。

公开(公告)号：US09291552B2

公开(公告)日：2016-03-22

申请号：US14631995

申请日：2015-02-26

Applicant: Engineered Medical Technologies

Inventor： Bryan John Cowger ,  Megan Anzar Babb

IPC: G01N21/00 ,  G01N21/33 ,  G01N21/03 ,  G01N21/13 ,  G01N21/17

CPC classification number: G01N21/33 ,  G01N21/03 ,  G01N21/13 ,  G01N2021/0367 ,  G01N2021/1751 ,  G01N2201/0446 ,  G01N2201/062

Abstract: The present describes a system and method for determining the concentration of tetrahydrocannabinol (THC) including a tray comprising a first analyte including an infusion of a solvent and cannabis, a light emitting element configured to illuminate the first analyte, a light receiving element configured to receive a first light transmitted through the first analyte, and a control circuit configured to calculate a concentration of tetrahydrocannabinol in the first analyte based at least in part on the first light.

Abstract translation: 本发明描述了一种用于测定四氢大麻酚（THC）的浓度的系统和方法，所述系统和方法包括包含第一分析物的托盘，所述第一分析物包括溶剂和大麻的输注，被配置为照射所述第一分析物的发光元件，被配置为接收 透射通过第一分析物的第一光;以及控制电路，被配置为至少部分地基于第一光计算第一分析物中的四氢大麻酚的浓度。

公开(公告)号：US09222875B2

公开(公告)日：2015-12-29

申请号：US14133199

申请日：2013-12-18

Applicant: NEXUS DX, INC.

Inventor： Richard Egan ,  Graham Lidgard ,  David Booker

IPC: G01N21/01 ,  G01N21/55 ,  G01N21/84 ,  G01N33/487 ,  G06F19/00

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US20150323454A1

公开(公告)日：2015-11-12

申请号：US14806999

申请日：2015-07-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Norikazu SUGIYAMA ,  Takuji KATAOKA ,  Ikuo ARATA

IPC: G01N21/47 ,  G01N33/483

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。