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公开(公告)号：US20160265029A1
公开(公告)日：2016-09-15
申请号：US15036398
申请日：2014-11-07
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. YING , Saravana Kumar KUMARASAMY
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/026 , B01L2200/147 , B01L2300/023 , B01L2300/024 , B01L2300/0829 , B01L2300/1822 , G01N21/251 , G01N21/253 , G01N21/78 , G01N2201/062 , G01N2201/0638 , G01N2201/0683
Abstract: A colorimetric-based DNA diagnostic system which includes a detector module, a processor and a memory is provided. The detector module is disposed to record an image of a DNA sample illuminated by a light source. The memory includes computer program code which along with the memory is configured, with the processor, to perform (a) sending a signal to adjust the temperature of the DNA sample to be within an approximate temperature range over which the color of the DNA sample changes, (b) sending a signal to the detector module to capture an image of the DNA sample at defined intervals within the approximate temperature range, (c) processing the captured images to extract color information, and (d) processing the extracted color information to objectively determine a melting temperature within the approximate temperature range at which the color of the DNA sample changes.
Abstract translation: 提供了一种基于比色的DNA诊断系统，其包括检测器模块，处理器和存储器。 检测器模块设置成记录由光源照射的DNA样品的图像。 存储器包括计算机程序代码，其与存储器一起配置处理器，以执行（a）发送信号以将DNA样本的温度调节到DNA样本的颜色变化的近似温度范围内 （b）向检测器模块发送信号以在大致温度范围内以规定的间隔捕获DNA样品的图像，（c）处理所捕获的图像以提取颜色信息，以及（d）将所提取的颜色信息处理为 客观地确定在DNA样品的颜色变化的近似温度范围内的熔融温度。
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公开(公告)号：US20160243550A1
公开(公告)日：2016-08-25
申请号：US15025858
申请日：2013-09-30
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. Ying , Saravana Kumar Kumarasamy , Rensheng Deng
CPC classification number: B01L3/502746 , B01L3/502738 , B01L2200/0642 , B01L2200/0647 , B01L2300/0636 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/0893 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0677 , B01L2400/0688 , B01L2400/084 , C12Q1/686 , C12Q1/689 , C12Q2600/16 , C12Q2531/107 , C12Q2565/629
Abstract: There is provided a microfluidic device comprising: a plurality of wells, each well having an inlet and an outlet, wherein the inlets are in fluid communication with one or more entry channels and the outlets are in fluid communication with one or more exit channels, wherein said outlet is connected to the exit channel via an outlet connecting channel and said inlet is connected to the entry channel via an inlet connecting channel wherein the dimension of the outlet connecting channel is configured such that the surface tension of a liquid comprised in the well prevents the release of the liquid through the outlet connecting channel. There is also provided a system, method and use of the device.
Abstract translation: 提供了一种微流体装置，其包括：多个井，每个井具有入口和出口，其中入口与一个或多个入口通道流体连通，并且出口与一个或多个出口通道流体连通，其中 所述出口通过出口连接通道连接到出口通道，并且所述入口通过入口连接通道连接到入口通道，其中出口连接通道的尺寸被构造成使得包含在井中的液体的表面张力防止 通过出口连接通道释放液体。 还提供了该设备的系统，方法和用途。
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333.发明授权公开(公告)号：US09423396B2
公开(公告)日：2016-08-23
申请号：US14367596
申请日：2012-12-20
Inventor： Young-Tae Chang , Sung Chan Lee , Nam-Young Kang , Seong Wook Yun , Cheryl Kit Mun Leong , Hyung Ho Ha
IPC: G01N33/53 , C07F5/02 , G01N33/569 , G01N33/58 , A61K49/00
CPC classification number: G01N33/5306 , A61K49/0021 , A61K49/006 , C07F5/02 , C07F5/022 , C09B23/0075 , C09B23/145 , G01N33/56966 , G01N33/582 , G01N2458/00
Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.
Abstract translation: 本发明涉及由结构式（I）表示的对神经干细胞特异性的荧光化合物：（I）或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了检测β细胞，胰岛和小神经胶质细胞的方法，其包括使用结构式（I）的化合物或其药学上可接受的盐。 结构式（I）的化合物还可以将健康的胰岛细胞与糖尿病胰岛细胞分化。
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公开(公告)号：US20160230234A1
公开(公告)日：2016-08-11
申请号：US15022917
申请日：2014-09-17
Inventor： Min-Han Tan , Yukti Choudhury , Puay Hoon Tan , Bin Tean Teh
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/166
Abstract: A method of making a prognosis as to whether a patient having renal cancer is like to survive in a tumour tissue sample obtained from the patient is provided. The method comprising determining the level of expression for each marker of a panel of markers comprising at least one housekeeping gene selected from the group consisting of ACTB, RPL13A, RPL9, and RPS29 and any combinations thereof and at least one prognostic gene selected from the group consisting of CXCL5, EFNA5, EMCN, G6PC, GFPT2, HIST2H3C, IGFBP1, LAMB3, MMP9, MOCOS, PLG, PRAME, RARRES1, SDPR, SLC6A19, TK1, KDELR3 and TSPAN7 and any combinations thereof, comparing the level of expression of each marker with a predetermined reference level associated with each marker, and determining the differential expression of each marker in the tumour tissue sample based on the expression parameter for each marker to provide a prognosis for renal cancer.
Abstract translation: 提供了一种关于患有肾癌的患者是否希望在从患者获得的肿瘤组织样品中存活的预后的方法。 所述方法包括确定包含至少一种选自ACTB，RPL13A，RPL9和RPS29及其任何组合的至少一个持家基因的标志物组的每个标志物的表达水平和至少一种选自下组的预后基因 由CXCL5，EFNA5，EMCN，G6PC，GFPT2，HIST2H3C，IGFBP1，LAMB3，MMP9，MOCOS，PLG，PRAME，RARRES1，SDPR，SLC6A19，TK1，KDELR3和TSPAN7及其任何组合组成，比较每个标志物的表达水平 具有与每个标记相关联的预定参考水平，并且基于每个标记物的表达参数确定肿瘤组织样品中每个标记物的差异表达以提供肾癌的预后。
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公开(公告)号：US20160220709A1
公开(公告)日：2016-08-04
申请号：US14917868
申请日：2014-09-09
Inventor： Malini Olivo , Kien Voon Kong , Weng Kee Leong
IPC: A61K49/22
CPC classification number: A61K49/22
Abstract: A photoacoustic imaging contrast agent composition is provided. The composition comprises a metal carbonyl cluster compound having the general formula (I) M3(CO)xL12-x wherein M at each occurrence denotes a metal selected from Group 6 to Group 11 of the Periodic Table of Elements; x is an integer from 10 to 12; and each L is independently selected from the group consisting of —H and -A-(CH2)n—COO−Y+, wherein A is selected from the group consisting of S, O, C and N; n is an integer from 1 to 10; and Y is any cation. Use of the photoacoustic imaging contrast agent composition in photoacoustic imaging is also provided.
Abstract translation: 提供光声成像造影剂组合物。 该组合物包含具有通式（I）M3（CO）xL12-x的金属羰基簇化合物，其中每次出现M表示选自元素周期表第6至11族的金属; x为10〜12的整数， 并且每个L独立地选自-H和-A-（CH 2）n -COO-Y +，其中A选自S，O，C和N; n是1至10的整数; Y是任何阳离子。 还提供了在光声成像中使用光声成像造影剂组合物。
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Patent Agency Ranking
336.发明申请POLYMER-FLAVONOID CONJUGATES AND HYDROGELS FOR BIOMEDICAL APPLICATIONS 审中-公开用于生物医学应用的聚合物 - 黄酮类化合物和水凝胶公开(公告)号：US20160213787A1
公开(公告)日：2016-07-28
申请号：US14916559
申请日：2014-09-01
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Motoichi KURISAWA , Ki Hyun BAE
Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.
Abstract translation: 提供了聚合物 - 类黄酮轭合物。 根据本发明公开了类黄酮接枝和类黄酮封端的聚合物缀合物。 黄酮与聚合物的连接已经通过硫醇键实现。 本发明的方法允许以高产率制备缀合物，避免了复杂的纯化步骤。 缀合物可以容易地自动氧化成水凝胶，其用途在许多生物医学应用中，其中黄酮类化合物的稳定性更高。 水凝胶可以用作粘合补充剂，抗粘连膜或真皮填料。
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337.发明申请公开(公告)号：US20160213268A1
公开(公告)日：2016-07-28
申请号：US14917932
申请日：2014-09-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Seong-Jin KIM , Minkyu JE
CPC classification number: A61B5/04001 , A61B5/0006 , A61B5/04004 , A61B5/0478 , A61B5/7282 , G01R23/00
Abstract: A method for determining an occurrence of a spike in one of a plurality of neural signals is provided, the spike relating to an action potential in the one of the plurality of neural signals. The method includes sampling the plurality of neural signals at a sampling frequency; extracting frequency features from each of the plurality of neural signals during sampling of the plurality of neural signals; and monitoring the extracted frequency features to determine characteristics of the one of the plurality of neural signals indicative of an occurrence of a spike.
Abstract translation: 提供了一种用于确定多个神经信号中的一个中的尖峰的出现的方法，所述尖峰与所述多个神经信号之一中的动作电位相关。 该方法包括以采样频率对多个神经信号进行采样; 在所述多个神经信号的采样期间从所述多个神经信号中的每一个提取频率特征; 以及监测所提取的频率特征以确定指示尖峰发生的所述多个神经信号之一的特征。
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公开(公告)号：US20160207899A1
公开(公告)日：2016-07-21
申请号：US15023668
申请日：2014-09-17
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Guangshun YI , Yugen ZHANG
IPC: C07D307/68 , B01J23/00 , B01J35/00 , B01J23/52
CPC classification number: C07D307/68 , B01J23/007 , B01J23/52 , B01J23/66 , B01J35/0013 , B01J37/035 , C07D307/48
Abstract: The present invention relates to a method for synthesizing an optionally substituted furoic acid by dehydrating a biomass and oxidizing the optionally substituted furan derived from the dehydration reaction. Water extraction has been incorporated as a step between the dehydration and the oxidation in order to purify the intermediate optionally substituted furan before having it oxidized. Prior to this water extraction, the organic solvent used for dehydration may be separated by evaporation. The provision of the water extraction allows impurities to be separated from the intermediate optionally substituted furan.
Abstract translation: 本发明涉及通过使生物质脱水并氧化来自脱水反应的任选取代的呋喃来合成任选取代的糠酸的方法。 水提取作为脱水和氧化之间的步骤被并入，以在中和任选取代的呋喃被氧化之前进行纯化。 在这种水提取之前，用于脱水的有机溶剂可以通过蒸发分离。 提供水提取允许杂质与中间任选取代的呋喃分离。
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公开(公告)号：US20160195519A1
公开(公告)日：2016-07-07
申请号：US14431723
申请日：2013-09-26
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Sydney Brenner , Yin Nah Teo , Farid Ghadessy , Leng Peng Walter Goh , Min Yen Lee
IPC: G01N33/542 , C07D495/04 , G01N33/58 , C07C255/41 , C07D455/04 , C07D519/00 , C07D219/08 , C07D401/14
CPC classification number: G01N33/542 , C07C255/41 , C07C2603/50 , C07D219/08 , C07D401/14 , C07D417/06 , C07D455/04 , C07D495/04 , C07D519/00 , G01N33/582
Abstract: The present invention relates to methods and compositions for detecting an interaction between a protein and a ligand, comprising: (i) binding at least one fluorescent molecular rotor to said ligand or protein; and (ii) detecting a change in fluorescence emitted by said fluorescent molecular rotor after contact of the bound fluorescent molecular rotor with the other of said ligand or protein, thereby detecting an interaction between the ligand and the protein, wherein the fluorescent molecular rotor comprises: a rotating ?-bond; an electron-donating moiety; an electron-accepting moiety; and a ?-conjugated linker.
Abstract translation: 本发明涉及用于检测蛋白质和配体之间相互作用的方法和组合物，其包括：（i）将至少一种荧光分子转子与所述配体或蛋白质结合; 和（ii）检测所述荧光分子转子在所述结合的荧光分子转子与所述配体或蛋白质中的另一个接触之后发射的荧光的变化，从而检测所述配体和所述蛋白质之间的相互作用，其中所述荧光分子转子包括： 旋转的？ 给电子部分; 电子接受部分; 和π共轭接头。
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340.发明授权公开(公告)号：US09373804B2
公开(公告)日：2016-06-21
申请号：US14618475
申请日：2015-02-10
Applicant: Agency for Science, Technology and Research
Inventor： Hongjun Liu , Wei Peng Goh , Jie Zhang , Ziyu Jin , Sing Yang Chiam
IPC: H01L29/08 , H01L51/42 , H01L51/50 , C23C18/00 , C09D11/00 , H01L31/032 , C09D11/52 , C01G39/02 , H01L51/44 , H01L51/00 , C09C1/00
CPC classification number: H01L51/422 , C01G39/02 , C01P2004/03 , C01P2006/40 , C09C1/0003 , C09D11/00 , C09D11/52 , C23C18/00 , H01L31/032 , H01L51/0037 , H01L51/0047 , H01L51/0068 , H01L51/4273 , H01L51/441 , H01L51/5056 , H01L51/5068 , H01L2251/303 , H01L2251/308 , Y02E10/549 , Y02P70/521
Abstract: Present invention relates to methods of preparing molybdenum oxide inks and molybdenum oxide films, and use of the molybdenum oxide films as hole-transporting layers in optoelectronic devices. The ink for forming a hybrid molybdenum (VI) oxide (MoO3) film on a substrate comprises an ammonium molybdate, at least one inorganic salt different from ammonium molybdate, and a solvent or a solvent mixture.
Abstract translation: 本发明涉及制备氧化钼油墨和氧化钼膜的方法，以及在光电器件中使用氧化钼膜作为空穴传输层。 用于在基材上形成杂化钼（VI）氧化物（MoO 3）膜的油墨包括钼酸铵，至少一种不同于钼酸铵的无机盐，以及溶剂或溶剂混合物。
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