公开(公告)号：US10072097B2

公开(公告)日：2018-09-11

申请号：US14812621

申请日：2015-07-29

Applicant: ACADEMIA SINICA

Inventor： Tzu-Ching Meng ,  Geen-Dong Chang ,  Ming-Fo Hsu

IPC: G01N33/68 ,  C07K16/44

CPC classification number: C07K16/44 ,  G01N33/6815 ,  G01N33/6842 ,  G01N2440/26

Abstract: The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.

公开(公告)号：US10023892B2

公开(公告)日：2018-07-17

申请号：US14723297

申请日：2015-05-27

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Che Ma

IPC: C07K16/00 ,  C12P19/14 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  C07K16/10 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C12N9/24 ,  C07K16/18 ,  A61K39/00

Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(α2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds FcγRIIA or FcγRIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

公开(公告)号：US20180163221A1

公开(公告)日：2018-06-14

申请号：US15838702

申请日：2017-12-12

Applicant: Academia Sinica

Inventor： Su-May Yu ,  Chun-Hsien Lu ,  Tuan-Hua David Ho ,  Shuen-Fang Lo

IPC: C12N15/82 ,  C12N9/16

CPC classification number: C12N15/8273 ,  C12N9/16 ,  C12N15/82 ,  C12N15/8255 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

Abstract: The present disclosure relates to transgenic plants that over-express PP2CABA and methods of using such for enhancing osmotic stress tolerance.

公开(公告)号：US20180156949A1

公开(公告)日：2018-06-07

申请号：US15599943

申请日：2017-05-19

Applicant: Academia Sinica

Inventor： Din-Ping TSAI ,  Pin-Chieh WU

IPC: G02B5/00 ,  G02B1/00

CPC classification number: G02B5/008 ,  G02B1/002 ,  G03H1/0244 ,  G03H1/0891

Abstract: The present invention provides an optical component comprising a dielectric layer and a nanorod array; the nanorod array is formed on a surface of the dielectric layer and extends along a lateral direction and a vertical direction. The nanorod array comprises a plurality of nanorods extending along the dielectric layer. The nanorods have a gap between one another, and an angle is defined by two adjacent nanorods. A bump is formed at each of two ends of the nanorod.

公开(公告)号：US09981030B2

公开(公告)日：2018-05-29

申请号：US14392333

申请日：2014-06-27

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Chia-Hung Wang ,  Shiou-Ting Li

IPC: A61K31/715 ,  C08B37/00 ,  A61K39/095 ,  C07H1/00 ,  C07H15/04 ,  C07H15/18 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K31/715 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6037 ,  A61K2039/627 ,  C07H1/00 ,  C07H15/04 ,  C07H15/18 ,  C08B37/006

Abstract: Described herein are synthetic glycan conjugates comprising a carrier and a glycan moiety derived from Neisseria meningitidis, wherein the glycan moiety is covalently linked to the carrier through a linker. Also provided herein are a mixture of the glycan conjugates thereof, immmunogenic compositions thereof, and kits thereof. The invention further provides methods of using the synthetic glycan conjugates and immunogenic compositions thereof to treat and/or reduce the risk of infectious diseases such as bacterial infections.

公开(公告)号：US09975965B2

公开(公告)日：2018-05-22

申请号：US15011543

申请日：2016-01-30

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Tsui-Ling Hsu ,  Yi-Wei Lou ,  Chih-Wei Lin ,  Shih-Chi Yeh ,  Chung-Yi Wu ,  Han-Chung Wu

IPC: C07K16/44 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/44 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  G01N33/57407 ,  G01N2800/52

Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

公开(公告)号：US09920347B2

公开(公告)日：2018-03-20

申请号：US15164968

申请日：2016-05-26

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Che Ma ,  Yung-Chieh Tseng

IPC: C12P21/00 ,  A61K39/12 ,  C07K14/005 ,  A61K39/145 ,  C12N7/00

CPC classification number: C12P21/005 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16111 ,  C12N2760/16121 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12Y302/01096 ,  G01N2333/00 ,  G01N2333/11 ,  Y02A50/386 ,  Y02A50/394 ,  Y02P20/52

Abstract: Methods for producing virus particles and viral antigens with simplified glycosylation profiles, such as mono-glycosylated forms of HIV, HCV, Dengue virus, West Nile virus and influenza virus. When used as targets for vaccine production, the conserved nature of such sites generate vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses or viral antigens with simplified glycosylation profiles.

公开(公告)号：US09906920B2

公开(公告)日：2018-02-27

申请号：US15411533

申请日：2017-01-20

Applicant: Academia Sinica

Inventor： Jane W. S. Liu ,  Jan Su ,  Cheng-Chieh Li

IPC: H04W24/00 ,  H04W4/04 ,  H04W40/24 ,  H04W64/00 ,  H04L12/24 ,  H04W84/12

CPC classification number: H04W4/40 ,  H04L41/145 ,  H04W4/04 ,  H04W40/244 ,  H04W64/00 ,  H04W84/12

Abstract: An indoor positioning system based on building design information is disclosed. The system includes a server computer to provide indoor position information relating to a building, a plurality of beacons to be installed in selected locations in the building and to broadcast by each beacon an indoor position message indicating the indoor position of the beacon, and an installer to configure the beacons with their corresponding indoor position information. An indoor positioning system development system is also provided. The development system incorporates building information files and provides a development interface for users to determine respective locations to install the beacons. Once completed, the obtained results are converted into an indoor position message for each beacon and configured in the corresponding beacon.

公开(公告)号：US09874562B2

公开(公告)日：2018-01-23

申请号：US15210565

申请日：2016-07-14

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun Edmund Cheng ,  Jiun-Jie Shie

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  A61K31/665 ,  A61K31/683 ,  C07F9/6552 ,  G01N2333/11

Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

公开(公告)号：US20170332645A1

公开(公告)日：2017-11-23

申请号：US15521927

申请日：2015-10-27

Applicant: Chi-Ming LIANG ,  Yet-Ran CHEN ,  Ying-Lan CHEN ,  Mei-Chun TSENG ,  Academia Sinica

Inventor： Yet-Ran Chen ,  Ying-Lan Chen ,  Mei-Chun Tseng

IPC: A01N65/38 ,  C07K14/415

CPC classification number: A01N65/38 ,  A61K38/00 ,  C07K14/415 ,  C12N15/8271 ,  C12N15/8279

Abstract: The present invention relates to a novel plant defense signaling peptide and applications thereof.