公开(公告)号：US09058885B2

公开(公告)日：2015-06-16

申请号：US13708866

申请日：2012-12-07

Applicant: Agency for Science, Technology and Research

Inventor： Yuanhong Luo ,  Gerard Franck Ernult

IPC: G11C11/00 ,  G11C11/16 ,  H01L43/02 ,  H01L43/08 ,  H01L43/10 ,  H01F10/32

CPC classification number: G11C11/1675 ,  G11C11/161 ,  G11C11/5607 ,  H01F10/3254 ,  H01F10/3263 ,  H01F10/3286 ,  H01L43/02 ,  H01L43/08 ,  H01L43/10

Abstract: A magnetoresistive device including a fixed magnetic layer structure, a first free magnetic layer structure, and a second free magnetic layer structure, wherein the fixed magnetic layer structure is arranged in between the first free magnetic layer structure and the second free magnetic layer structure, wherein the magnetization orientation of the first free magnetic layer structure is variable in response to a first electrical signal of a first polarity and the magnetization orientation of the second free magnetic layer structure is at least substantially non-variable in response to the first electrical signal, and wherein the magnetization orientation of the second free magnetic layer structure is variable in response to a second electrical signal of a second polarity and the magnetization orientation of the first free magnetic layer structure is at least substantially non-variable in response to the second electrical signal, wherein the second polarity is opposite to the first polarity.

Abstract translation: 一种包括固定磁性层结构，第一自由磁性层结构和第二自由磁性层结构的磁阻器件，其中固定磁性层结构布置在第一自由磁性层结构和第二自由磁性层结构之间，其中 第一自由磁性层结构的磁化取向响应于第一极性的第一电信号是可变的，并且第二自由磁性层结构的磁化方向响应于第一电信号至少基本上不可变;以及 其中所述第二自由磁性层结构的磁化取向响应于第二极性的第二电信号是可变的，并且所述第一自由磁性层结构的磁化取向响应于所述第二电信号至少基本上不可变， 其中所述第二极性与所述第一极性相反 性。

公开(公告)号：US20150160409A1

公开(公告)日：2015-06-11

申请号：US14565083

申请日：2014-12-09

Applicant: Agency for Science, Technology and Research ,  Nanyang Technological University

Inventor： Yicheng Lai ,  Feng Luan

IPC: G02B6/02

CPC classification number: G02B6/02147 ,  G02B2006/02157 ,  G02B2006/02161

Abstract: Various embodiments provide a method of fabricating a fibre, the method comprising translating a fibre having a light transmissive core surrounding by a cladding material; and while translating, non-interferometrically applying energy to alter structure of the light transmissive core and/or the cladding material.

Abstract translation: 各种实施例提供一种制造光纤的方法，该方法包括平移具有由包层材料围绕的透光芯的纤维; 并且同时平移非干涉地施加能量以改变透光芯和/或包层材料的结构。

公开(公告)号：US20150148528A1

公开(公告)日：2015-05-28

申请号：US14555257

申请日：2014-11-26

Applicant: Agency for Science, Technology and Research

Inventor： Peter Gagnon

IPC: C07H21/04

CPC classification number: C12N15/101 ,  B01D15/362 ,  C07H21/04 ,  C12N15/1006 ,  C12N15/1017

Abstract: A method of purifying a sample that includes a polynucleotide includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the polynucleotide in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the polynucleotide from the packed chromatographic column, where the polynucleotide is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.

Abstract translation: 纯化包含多核苷酸的样品的方法包括以下步骤：（i）提供具有带负电荷的多孔颗粒的填充色谱柱，（ii）将色谱柱平衡到待洗脱的样品中的多核苷酸的条件，（iii ）使样品与填充色谱柱接触，使得施加到填充色谱柱的样品体积小于或等于填充色谱柱内带负电荷的多孔颗粒的颗粒间间隔，（iv）从包装的色谱柱中洗脱多核苷酸 色谱柱，其中多核苷酸处于更纯的状态和在填充色谱柱平衡的条件下。

公开(公告)号：US20150130039A1

公开(公告)日：2015-05-14

申请号：US14372015

申请日：2013-06-18

Applicant: Agency for Science, Technology and Research

Inventor： Vivek Chidambaram ,  Ling Xie ,  Ranganathan Nagarajan ,  Bangtao Chen ,  Beng Yeung Ho

IPC: H01L23/26 ,  B81B7/00 ,  B81C1/00

CPC classification number: H01L23/26 ,  B81B7/0038 ,  B81C1/00285 ,  C22C14/00 ,  C22C19/03 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The invention relates to a layer arrangement and a wafer level package comprising the layer arrangement, and in particular, the layer arrangement comprises a getter layer and further comprises a sacrificial layer. The wafer level package may be used in microelectromechanical systems (MEMS) packaging at a vacuum level of about 10 mTorr or less such as close to 1 mTorr (i.e. MEMS vacuum packaging).

Abstract translation: 本发明涉及一种层布置和包括层布置的晶片级封装，并且具体地，该层布置包括吸气剂层并且还包括牺牲层。 晶片级封装可以在大约10mTorr或更小的真空度，例如接近1mTorr（即MEMS真空封装）的微电子机械系统（MEMS）封装中使用。

公开(公告)号：US20150125950A1

公开(公告)日：2015-05-07

申请号：US14401872

申请日：2013-05-17

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) ,  SINGAPORE HEALTH SERVICES PTE LTD

Inventor： Sai Kiang Lim ,  Kok Hian Tan

IPC: C12N5/0775

CPC classification number: C12N5/0668 ,  A61K35/28 ,  A61K35/51 ,  C12N5/0665 ,  C12N2500/02 ,  C12N2510/04

Abstract: We describe a method of cell culture of an umbilical mesenchymal stem cell (MSC). The method comprises the steps of providing an umbilical mesenchymal stem cell (MSC) and culturing the umbilical mesenchymal stem cell in a cell culture medium under hypoxic conditions. The umbilical mesenchymal stem cell may be transformed with an oncogene such as c-myc. Conditioned media and exosomes obtained from the umbilical mesenchymal stem cell may be used for therapy.

Abstract translation: 我们描述了脐带间充质干细胞（MSC）的细胞培养方法。 该方法包括在缺氧条件下在细胞培养基中提供脐带间充质干细胞（MSC）并培养脐带间充质干细胞的步骤。 可以用诸如c-myc的致癌基因转化脐带间充质干细胞。 从脐带间充质干细胞获得的条件培养基和外来体可用于治疗。

公开(公告)号：US20150125537A1

公开(公告)日：2015-05-07

申请号：US14535568

申请日：2014-11-07

Applicant: Agency for Science, Technology and Research ,  National University of Singapore

Inventor： Cho Hong James Goh ,  Pujiang Shi ,  Hee Kit Wong ,  Yong Zhang ,  Sunny Akogwu Abbah ,  Jun Li

IPC: A61L27/54 ,  A61L27/50 ,  A61L27/34 ,  A61L27/56

CPC classification number: A61L27/54 ,  A61L27/14 ,  A61L27/306 ,  A61L27/32 ,  A61L27/50 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  A61L2430/02

Abstract: There is provided a bone filler material comprising a plurality of particles, each particle comprising a biodegradable outer shell and an inner core. There is also provided an implant prepared from the same, methods of using the same and preparing the same.

Abstract translation: 提供了包含多个颗粒的骨填充材料，每个颗粒包括可生物降解的外壳和内核。 还提供了由其制备的植入物，使用该植入物并制备其的方法。

公开(公告)号：US20150098976A1

公开(公告)日：2015-04-09

申请号：US14047056

申请日：2013-10-07

Applicant: Agency For Science, Technology and Research ,  International Business Machines Corporation

Inventor： Xin Ding ,  James L. Hedrick ,  Chuan Yang ,  Yi Yan Yang

IPC: A61L29/08 ,  A61L29/16

CPC classification number: A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  C08L69/00

Abstract: Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.

Abstract translation: 制备含儿茶酚的聚碳酸酯（儿茶酚聚合物），其包含i）包含侧链儿茶酚基团的儿茶酚重复单元，ii）包含侧链阳离子基团的阳离子重复单元，所述侧链阳离子基团选自季胺基，季膦基， 和其组合，以及iii）包含聚合度为约5至约30的侧链聚（环氧乙烷）基团的PEG重复单元。儿茶酚聚合物在各种基材表面上形成抗微生物和防污膜，特别是 硅橡胶。

公开(公告)号：US08999916B2

公开(公告)日：2015-04-07

申请号：US13751295

申请日：2013-01-28

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte Hauser ,  Wei Yang Seow

IPC: A61K38/00 ,  A01N25/00 ,  A61K47/00 ,  C12N5/00 ,  C12N5/02 ,  A61K47/42 ,  A61K38/02 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L26/00

CPC classification number: A61L27/3804 ,  A61K9/06 ,  A61K35/33 ,  A61K38/02 ,  A61K47/42 ,  A61L26/0028 ,  A61L26/0061 ,  A61L26/008 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/412 ,  A61L2300/426 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/06 ,  A61L2430/38 ,  C12N5/0018 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0671 ,  C12N5/0691 ,  C12N2513/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2537/10

Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.

Abstract translation: 本发明涉及水凝胶，其包含能够自组装成三维大分子纳米纤维网络的多个两亲肽和/或拟肽，其夹带水并形成所述水凝胶，其中所述多个两亲肽的至少一部分和/ 或拟肽化学交联。 本发明还涉及制备这种水凝胶的方法和这种水凝胶的各种用途，例如， 作为用于药物和基因递送的细胞培养底物，作为伤口敷料，作为植入物，作为原位凝胶的药物或化妆品组合物，再生医学，组织工程和组织再生或电子装置中的注射剂。 它还涉及使用根据本发明的水凝胶的组织再生或组织置换的方法。

公开(公告)号：US20150057470A1

公开(公告)日：2015-02-26

申请号：US14390757

申请日：2013-04-05

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Guangshun Yi ,  Yugen Zhang

IPC: C07C29/132

CPC classification number: C07C29/132 ,  C07C31/18 ,  C07C31/26

Abstract: A method for synthesizing a sugar alcohol comprising the step of hydrolyzing a polysaccharide in the presence of hydrogen ions (H+), an alcoholic reducing agent and a hydrogen transfer catalyst to form the sugar alcohol.

Abstract translation: 一种合成糖醇的方法，包括在氢离子（H +），醇还原剂和氢转移催化剂存在下水解多糖以形成糖醇的步骤。

公开(公告)号：US20150055242A1

公开(公告)日：2015-02-26

申请号：US14464538

申请日：2014-08-20

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Moulay Rachid ELIDRISSI ,  Kheong Sann CHAN ,  Zhimin YUAN

IPC: G11B20/10 ,  G11B5/09

CPC classification number: G11B20/10046 ,  G11B5/09 ,  G11B20/10305 ,  G11B20/10388 ,  G11B20/10472

Abstract: A method and system for estimating the position error signal (PES) metric for a magnetic storage system. The method comprises the steps of reading multiple readback tracks from a storage medium of the magnetic storage system using respective readers of a multiple reader head positioned at or near a data track of interest; employing an adaptive SMR equalizer to equalize the signals from the multiple read head; and extracting information from the adaptive SMR equalizer sub-filters as an estimate of the PES metric.

Abstract translation: 一种用于估计磁存储系统的位置误差信号（PES）度量的方法和系统。 该方法包括以下步骤：使用位于感兴趣的数据轨道上或附近的多个读取头的相应读取器从磁性存储系统的存储介质读取多个回读轨迹; 使用自适应SMR均衡器来均衡来自多个读取头的信号; 以及从所述自适应SMR均衡器子滤波器中提取信息作为所述PES度量的估计。