公开(公告)号：US20030159742A1

公开(公告)日：2003-08-28

申请号：US10371812

申请日：2003-02-21

Applicant: Nanostream, Inc.

Inventor： Christoph D. Karp ,  Adrian Hightower

IPC: F15C001/06

CPC classification number: B01F5/0471 ,  B01F13/0059 ,  B01F15/0264 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  G01N30/10 ,  G01N30/6095 ,  Y10T137/2224

Abstract: A splitter for multi-layer microfluidic devices is provided. The splitter includes multiple forked channels defined in two or more device layers. The forked channels communicate fluidically at overlap regions. The overlap regions, in combination with symmetrical channel geometries balance the fluidic impedance in the system and promote even splitting.

Abstract translation: 提供了用于多层微流体装置的分离器。 分离器包括在两个或更多个设备层中限定的多个分叉通道。 叉形通道在重叠区域流动地通信。 重叠区域与对称沟道几何结合平衡系统中的流体阻抗并促进均匀分裂。

公开(公告)号：US20030133358A1

公开(公告)日：2003-07-17

申请号：US10138959

申请日：2002-05-03

Applicant: Nanostream, Inc.

Inventor： Christoph D. Karp

IPC: B01F005/06 ,  B01F013/00

CPC classification number: B01F5/0471 ,  B01F5/0604 ,  B01F5/0646 ,  B01F13/0059 ,  Y10S366/04

Abstract: Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished with various manipulations of fluid flow paths and/or contacts between fluid streams. In various embodiments, structures such as channel overlaps, slits, converging/diverging regions, turns, and/or apertures may be designed into a mixing device. Mixing devices may be rapidly constructed and prototyped using a stencil construction method in which channels are cut through the entire thickness of a material layer, although other construction methods including surface micromachining techniques may be used.

Abstract translation: 强大的微流体混合装置将被动地混合多个流体流，而不使用运动部件。 在一个实施例中，这些装置包含在三维结构的各个层中形成的微流体通道。 混合可以通过流体流动路径和/或流体流之间的接触的各种操作来实现。 在各种实施例中，可以将诸如通道重叠，狭缝，会聚/发散区域，匝和/或孔的结构设计成混合装置。 混合装置可以使用模板施工方法进行快速构造和原型制备，其中通道切割材料层的整个厚度，尽管可以使用包括表面微加工技术的其他构造方法。

公开(公告)号：US20030106799A1

公开(公告)日：2003-06-12

申请号：US10313231

申请日：2002-12-06

Applicant: Nanostream, Inc

Inventor： Joseph F. Covington ,  Steven E. Hobbs ,  Jeffrey A. Koehler ,  Paren P. Patel ,  Marci Pezzuto ,  Mark S. Scheib

IPC: G01N027/453

CPC classification number: B01L3/502707 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B29C65/18 ,  B29C66/02 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/71 ,  B29C66/727 ,  B29C66/73112 ,  B29C66/8322 ,  B29C66/91212 ,  B29C66/91213 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91231 ,  B29C66/91411 ,  B29C66/91445 ,  B29C66/91645 ,  B29C66/92445 ,  B29C66/929 ,  B29C66/961 ,  B29K2023/00 ,  B29K2023/12 ,  B29L2031/756 ,  B32B37/0023 ,  B32B37/08 ,  B32B37/10 ,  B32B38/004 ,  B32B41/00 ,  B32B2037/0092 ,  B32B2038/166 ,  B32B2309/02 ,  B32B2309/022 ,  B32B2309/12 ,  B32B2310/024 ,  B81B2201/058 ,  B81C1/00119 ,  B81C3/008 ,  B81C2201/019 ,  G01N27/44791 ,  G01N30/6095 ,  Y10T29/49002 ,  Y10T137/0402 ,  Y10T137/2224 ,  Y10T137/598 ,  B29C2035/0827 ,  B29K2067/00

Abstract: A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).

Abstract translation: 一种制造微流体装置的方法，其中设置有第一和第二基本平坦的压板。 还提供了多个基本平坦的，基本上无金属的无粘合剂聚合物器件层，所述器件层包括第一覆盖层，第二覆盖层和限定穿透模板层的整个厚度的微流体通道的至少一个模板层。 每个模版层设置在其它装置层之间，使得通道被模板层横向限定，并且由周围的装置层从上方和下方界定，以限定上通道表面和下通道表面。 装置层堆叠在第一压板和第二压板之间。 根据适于形成基本上密封的无粘合微流体装置的加热轮廓可控制地加热堆叠的装置层，其中每个上部通道表面保持与其相应的下部通道表面不同。 所得到的微流体装置具有高的层间结合强度，同时保持在模版层中定义的通道的完整性。

公开(公告)号：US20020187072A1

公开(公告)日：2002-12-12

申请号：US10139060

申请日：2002-05-02

Applicant: Nanostream, Inc.

Inventor： Christoph D. Karp

IPC: G01N021/05

CPC classification number: B01F15/0205 ,  B01F5/0471 ,  B01F5/064 ,  B01F13/0059 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00891 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688

Abstract: Multi-layer microfluidic splitting devices are provided. A common fluid inlet fluidly communicates with a branching channel network that evenly divides a fluid flow to a plurality of outlets. Even splitting is provided by maintaining substantially equal fluidic impedance across all branch channels. Substantially equal fluidic impedance may be provided by maintaining a substantially equal flow path length between the common inlet and each of the outlets. The use of multiple device layers permits fabrication of such a device without geometrically complex channel structures, high feature density, and two-dimensional outlet arrays.

Abstract translation: 提供多层微流体分离装置。 常见的流体入口与分流通道网络流体连通，该分支通道网将流体流均匀地分配到多个出口。 通过在所有分支通道上保持基本相等的流体阻抗来提供均匀分裂。 可以通过在公共入口和每个出口之间保持基本相等的流路长度来提供基本上相等的流体阻抗。 使用多个器件层允许制造这样的器件而没有几何复杂的通道结构，高特征密度和二维出口阵列。

公开(公告)号：US20020185431A1

公开(公告)日：2002-12-12

申请号：US10145968

申请日：2002-05-13

Applicant: Nanostream, Inc.

Inventor： Christoph D. Karp

IPC: B01D029/01

CPC classification number: B01L3/502753 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00833 ,  B01J2219/00909 ,  B01L3/502707 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  Y10T137/2224

Abstract: Multi-layer microfluidic devices incorporating a filter element are provided. A filter element is compressively restrained between device layers, such that the compression promotes a tight seal between device layers and resists fluid leakage around the filter element.

Abstract translation: 提供了包含滤芯的多层微流体装置。 过滤元件被压缩地约束在装置层之间，使得压缩促进装置层之间的紧密密封并抵抗过滤元件周围的流体泄漏。

公开(公告)号：US20020185183A1

公开(公告)日：2002-12-12

申请号：US10160393

申请日：2002-05-30

Applicant: Nanostream, Inc.

Inventor： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker

IPC: F15C001/12

CPC classification number: B01F5/064 ,  B01F13/0059 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00869 ,  B01J2219/00891 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B29C65/02 ,  B29C66/02 ,  B29C66/026 ,  B29C66/71 ,  B29K2023/00 ,  B29K2023/12 ,  B29L2031/756 ,  B81B2201/058 ,  B81C3/008 ,  G01N30/6095 ,  G01N2030/565 ,  Y10T137/206 ,  Y10T137/212 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/8359 ,  B29C2035/0827 ,  B29K2067/00

Abstract: Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features (nullcommon fluidsnull) may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.

Abstract translation: 提供具有用于并行执行一个或多个流体操作的多个功能特征的微流体装置。 可以通过一个或多个分配输入将多个功能特征（“普通流体”）共同的试剂，样品或其它流体输入到微流体装置或系统中，根据需要分配和分配普通流体。 使用多层制造技术允许多个分配输入分配到微流体装置中的多个功能特征，而不需要不需要的流体通道交叉。

公开(公告)号：US20020124896A1

公开(公告)日：2002-09-12

申请号：US10134119

申请日：2002-04-25

Applicant: Nanostream, Inc.

Inventor： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker ,  Marci Pezzuto

IPC: F15C001/06

CPC classification number: B01F5/064 ,  B01F13/0059 ,  B01F15/0205 ,  B01F15/0264 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688 ,  G01N35/10 ,  G01N2035/00326 ,  Y10T137/0402 ,  Y10T137/2147 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/5109 ,  Y10T137/5283

Abstract: A modular microfluidic system includes a plurality of discrete microfluidic modules each capable of performing at least one operation and at least one microfluidic coupling device for fluidically coupling the modules to perform a sequence of operations. The microfluidic modules and coupling devices may be constructed according to various techniques. In one embodiment, coupling devices are fabricated from multiple layers and each include a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems and methods capable of performing various sequences of operations.

Abstract translation: 模块化微流体系统包括多个离散微流体模块，每个离散的微流体模块能够执行至少一个操作和至少一个微流体耦合装置，用于流体耦合模块以执行一系列操作。 微流体模块和耦合装置可以根据各种技术构造。 在一个实施例中，耦合装置由多个层制成，并且每个包括流体入口端口，流体出口端口和至少一个夹在其中形成有微流体通道的夹层模板层。 还描述了能够执行各种操作序列的集成微流体系统和方法。

公开(公告)号：US20020097633A1

公开(公告)日：2002-07-25

申请号：US10046071

申请日：2002-01-11

Applicant: NANOSTREAM,INC.

Inventor： Stephen D. O'Connor ,  Christoph D. Karp

IPC: B01F005/06 ,  B01F013/00

CPC classification number: B01D17/00 ,  B01D17/0208 ,  B01D17/08 ,  B01F5/0471 ,  B01F5/0604 ,  B01F5/064 ,  B01F13/0059 ,  B01F15/0205 ,  B01F15/0264 ,  B01L3/5027 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N2035/00237 ,  G01N2035/00544 ,  Y10T137/2224

Abstract: Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished with various manipulations of fluid flow paths and/or contacts between fluid streams. In various embodiments, structures such as channel overlaps, slits, converging/diverging regions, turns, and/or apertures may be designed into a mixing device. Mixing devices may be rapidly constructed and prototyped using a stencil construction method in which channels are cut through the entire thickness of a material layer, although other construction methods including surface micromachining techniques may be used.

Abstract translation: 强大的微流体混合装置将被动地混合多个流体流，而不使用运动部件。 在一个实施例中，这些装置包含在三维结构的各个层中形成的微流体通道。 混合可以通过流体流动路径和/或流体流之间的接触的各种操作来实现。 在各种实施例中，可以将诸如通道重叠，狭缝，会聚/发散区域，匝和/或孔的结构设计成混合装置。 混合装置可以使用模板施工方法进行快速构造和原型制备，其中通道切割材料层的整个厚度，尽管可以使用包括表面微加工技术的其他构造方法。

公开(公告)号：US20020039280A1

公开(公告)日：2002-04-04

申请号：US09964742

申请日：2001-09-28

Applicant: Nanostream, Inc.

Inventor： Stephen D. O'Connor ,  Eugene Dantsker

IPC: H05K007/20

CPC classification number: H01L23/473 ,  B81B1/00 ,  F28F2260/02 ,  G11B33/1413 ,  H01L2924/0002 ,  H01L2924/00

Abstract: In accordance with the present invention there is provided a microfluidic heat exchange system for cooling heat-generating components of electronic equipment, computers, lasers, analytical instruments, medical equipment and the like. Both direct contact and indirect contact microfluidic systems are described. Also described are microfluidic systems that incorporate remote heat rejection systems that may be located outside the body of the equipment that contains the heat generating components that need cooling.

Abstract translation: 根据本发明，提供了一种用于冷却电子设备，计算机，激光器，分析仪器，医疗设备等的发热部件的微流体热交换系统。 描述了直接接触和间接接触微流体系统。 还描述了微流体系统，其包括可以位于设备外部的远程排热系统，其包含需要冷却的发热部件。