公开(公告)号：US07758810B2

公开(公告)日：2010-07-20

申请号：US11875973

申请日：2007-10-22

申请人： Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Jung-suk Yoo

发明人： Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Jung-suk Yoo

IPC分类号： G01N21/07 ,  G01B11/00

CPC分类号： G01N35/00069 ,  B01L3/5027 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2400/0409 ,  G01N35/0092 ,  G01N2035/00574

摘要： Provided is a centrifugal force based microfluidic system including: a microfluidic device including a rotatable platform and an optical path formed to extend horizontally in a straight line from a circumference of the platform; a motor rotating so as to control the microfluidic device; a light emitting unit emitting light towards the microfluidic device; a light receiving unit detecting the light emitted from the light emitting unit; and a controller determining a home position to be the position of the microfluidic device at a point of time when the light emitted from the light emitting unit is detected by the light receiving unit, wherein the light emitted from the light emitting unit passes through the optical path to be incident on the light receiving unit only when the microfluidic device is located in a predetermined position.

摘要翻译： 提供了一种基于离心力的微流体系统，包括：微流体装置，其包括可旋转平台和形成为从平台的圆周以直线水平延伸的光路; 旋转的马达以控制微流体装置; 向所述微流体装置发射光的发光单元; 光接收单元，检测从所述发光单元发射的光; 以及控制器，其在从所述光接收单元检测到从所述发光单元发射的光的时刻，将所述微流体装置的位置确定为所述位置，其中，从所述发光单元发射的光通过所述光 仅当微流体装置位于预定位置时入射在光接收单元上的路径。

公开(公告)号：US20080112855A1

公开(公告)日：2008-05-15

申请号：US11937135

申请日：2007-11-08

申请人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

发明人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

IPC分类号： B01J19/00 ,  F16K13/10

CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T137/4643 ,  Y10T436/2575

摘要： Provided are a valve unit and a microfluidic device including the valve unit. The valve unit includes: a valve substance container containing a valve substance, the valve substance including a phase change material that is solid at ambient temperature and melts by absorbing energy; a valve connection path connecting the valve substance container to a channel forming a fluid passage; and a pair of drain chambers formed along the channel at both sides of the valve connection path.

摘要翻译： 提供了包括阀单元的阀单元和微流体装置。 所述阀单元包括：阀体物质容器，其容纳阀门物质，所述阀门物质包括在环境温度下为固体并通过吸收能量而熔化的相变材料; 将阀体容器连接到形成流体通道的通道的阀连接路径; 以及在阀连接路径的两侧沿着通道形成的一对排水室。

公开(公告)号：US08469492B2

公开(公告)日：2013-06-25

申请号：US12620856

申请日：2009-11-18

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

IPC分类号： B41J2/06

CPC分类号： B41J2/06 ,  B41J2/14

摘要： A method of printing droplets using capillary electric charge concentration includes: providing a capillary nozzle comprising a back-end part and a front-end part disposed substantially opposite the back-end part; spacing a target member apart from the front-end part of the capillary nozzle at a predetermined distance; immersing the back-end part in a solution; and supplying a voltage to the solution. The back-end part transmits the solution to the front-end part.

摘要翻译： 使用毛细管电荷浓度印刷液滴的方法包括：提供包括后端部分和基本上与后端部分相对设置的前端部分的毛细管喷嘴; 将目标构件与毛细管喷嘴的前端部隔开预定距离; 将后端部分浸入溶液中; 并向该溶液提供电压。 后端部分将解决方案传输到前端部分。

公开(公告)号：US08420026B2

公开(公告)日：2013-04-16

申请号：US13594293

申请日：2012-08-24

申请人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

发明人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

IPC分类号： B04B13/00

CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

摘要： A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

摘要翻译： 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。

公开(公告)号：US20120028851A1

公开(公告)日：2012-02-02

申请号：US13269333

申请日：2011-10-07

申请人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeong Park ,  Jeong-gun Lee

发明人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeong Park ,  Jeong-gun Lee

IPC分类号： C40B60/12

CPC分类号： B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

摘要翻译： 提供了用于同时进行两种或更多种测定的可旋转的微流体装置。 该装置包括能够旋转的平台，第一单元，其设置在平台的一部分处，并且从附着有目标材料的捕获探针的样品使用表面检测目标材料;以及第二单元 其设置在平台的另一部分并且通过与在第一单元中进行的反应的不同反应来检测包含在样品中的目标材料。

公开(公告)号：US08101138B2

公开(公告)日：2012-01-24

申请号：US11837038

申请日：2007-08-10

申请人： Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

发明人： Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

IPC分类号： B01L3/00 ,  F04B19/00

CPC分类号： G01N35/00069 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/043 ,  G01N35/0098 ,  Y10T436/25375

摘要： A centrifugal micro fluidic system and a centrifugal magnetic position control device used in the centrifugal micro fluidic system for controlling the position of magnetic beads are provided. The centrifugal micro fluidic system comprising, a rotatable platform; a micro fluidic structure which is disposed in the platform; and a plurality of objects which include functional groups on surfaces thereof so as to capture a target material from the fluid and carry the target material while being suspended in and separated from the fluid in the micro fluidic structure, wherein the movements of the objects are controlled by a force affecting the objects differently compared to the force's effect on the fluid. When the objects are made of a magnetic material, the force may be a magnetic force applied by the centrifugal magnetic position control device.

摘要翻译： 提供了一种用于离心微流体系统中用于控制磁珠位置的离心微流体系统和离心磁位置控制装置。 离心微流体系统包括：可旋转平台; 设置在平台中的微流体结构; 以及包括在其表面上的官能团的多个物体，以便从流体中捕获目标材料并且在悬浮在微流体结构中的流体中并与微流体结构中的流体分离时携带目标材料，其中物体的移动被控制 通过影响对象的力与力对液体的影响不同。 当物体由磁性材料制成时，力可以是由离心磁位置控制装置施加的磁力。

公开(公告)号：US20110257037A1

公开(公告)日：2011-10-20

申请号：US13168298

申请日：2011-06-24

申请人： Beom-seok LEE ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

发明人： Beom-seok LEE ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

IPC分类号： C40B40/00 ,  C40B40/10 ,  C40B40/02 ,  C40B40/06

CPC分类号： B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

摘要： Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.

摘要翻译： 公开了一种微流体装置，其包括在平台中形成的微流体结构，其中可以使用生物分子微阵列芯片自动执行各种检查，例如免疫血清检查。 使用生物分子微阵列芯片的生物分子微阵列芯片型微流器件包括：可旋转的平台; 设置在平台中的微流体结构，包括：多个室; 连接所述室的多个通道; 以及多个阀，其控制通过所述通道的流体流动，其中所述微流体结构通过所述平台和所述阀的旋转来控制流体样品的流动; 以及安装在平台中的生物分子微阵列芯片，使得与生物分子微阵列芯片结合的生物分子捕获探针与微流体结构中的流体样品接触。

公开(公告)号：US07980272B2

公开(公告)日：2011-07-19

申请号：US12133396

申请日：2008-06-05

申请人： Jong-myeon Park ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

发明人： Jong-myeon Park ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

IPC分类号： F15C1/04

CPC分类号： F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T29/49412 ,  Y10T137/2191 ,  Y10T137/2196

摘要： Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves.

摘要翻译： 本发明提供一种微流体阀，微流体阀的制造方法和采用该微流体阀的微流体装置。 该微流体阀包括一个平台，该平台包括彼此相结合的两个基板; 具有允许流体在两个基板之间流动的第一深度的通道; 阀间隙，其设置在所述通道的至少一个区域上，并且具有小于所述第一深度的第二深度; 以及阀塞，其设置成填充阀间隙，并且由阀室材料形成，所述阀门材料是通过将在室温下为固体的相变材料与多个放出足以熔化的 相变材料吸收电磁波。

公开(公告)号：US07794054B2

公开(公告)日：2010-09-14

申请号：US11746299

申请日：2007-05-09

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

IPC分类号： B41J2/06

CPC分类号： B41J2/06

摘要： A droplet printing apparatus using capillary electric charge concentration includes a reservoir which contains a solution, a capillary nozzle comprising a back-end part and a front-end part disposed substantially opposite the back-end part, a target member spaced apart from the front-end part of the capillary nozzle at a predetermined distance, and a voltage supplier which supplies a voltage to the solution, wherein the back-end part is immersed in the solution and transmits the solution to the front-end part.

摘要翻译： 使用毛细管电荷浓度的液滴印刷装置包括：包含溶液的储存器，包括后端部分的毛细管喷嘴和基本上与后端部分相对设置的前端部分，与前端部分间隔开的目标部件， 在预定距离的毛细管喷嘴的端部，以及向溶液提供电压的电压供给器，其中后端部分浸入溶液中并将溶液传输到前端部分。

公开(公告)号：US20080305006A1

公开(公告)日：2008-12-11

申请号：US12053656

申请日：2008-03-24

申请人： Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

发明人： Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

IPC分类号： B01J19/00

CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L2200/028 ,  B01L2300/0803 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/255 ,  Y10T436/2575

摘要： A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container.

摘要翻译： 一种微流体装置，其具有包括流体被输送的通道的基板，容纳有至少一种流体的流体容器，并且设置在所述基板上以允许流体朝向所述流路流动， 流体流量控制器，其控制流体朝向来自流体容器的通道的流动。