公开(公告)号：US20180153476A1

公开(公告)日：2018-06-07

申请号：US15826296

申请日：2017-11-29

Applicant: Cardiac Pacemakers, Inc.

Inventor： Elizabeth Mary Annoni ,  Pramodsingh Hirasingh Thakur ,  Qi An ,  Sandra Nagale ,  Bryan Allen Clark ,  Thomas Christen ,  Edward A. Goldberg

IPC: A61B5/00 ,  A61B5/0205 ,  G06F19/00

CPC classification number: A61B5/7275 ,  A61B5/0022 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/02416 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1112 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/14542 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/4839 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/746 ,  A61B7/00 ,  A61B7/04 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/36117 ,  A61N1/36514 ,  A61N1/36535 ,  A61N1/36564 ,  A61N1/3702 ,  G16H50/30

Abstract: This document discusses, among other things, systems and methods for detecting stroke. A system may comprise a sensor circuit for sensing a physiological signal, and a second sensor to detect a physical state change. The physical state change may include a transition in physical activity, posture, or sleep state. A stroke risk circuit may detect, from the sensed physiological signal, a signal indicative of blood pressure surge (BPS) in response to one or more physical state changes. The system may generate a stroke risk indicator indicating a risk of developing an impending stroke event using the detected BPS. The system includes an output unit that outputs the stroke risk indicator to a user or a process.

公开(公告)号：US20180153416A1

公开(公告)日：2018-06-07

申请号：US15830893

申请日：2017-12-04

Applicant: Cardiac Pacemakers, Inc.

Inventor： Melanie Anne Zile ,  Pramodsingh Hirasingh Thakur ,  Qi An

IPC: A61B5/0205 ,  A61N1/365 ,  A61N1/39 ,  A61B5/00

CPC classification number: A61B5/02055 ,  A61B5/024 ,  A61B5/0531 ,  A61B5/0816 ,  A61B5/1118 ,  A61B5/7246 ,  A61B5/7264 ,  A61B7/04 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/37252 ,  A61N1/3956 ,  A61N1/39622

Abstract: This document discusses, among other things, systems and methods to receive physiologic information from a patient and to generate a heart failure status using the received physiologic information. Based on the received physiologic information, the generated heart failure status can be classified into at least one of a set of predetermined phenotype clusters.

公开(公告)号：US20180021582A1

公开(公告)日：2018-01-25

申请号：US15654393

申请日：2017-07-19

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： Qi An ,  Michael J. Kane ,  Yinghong Yu ,  Jeffrey E. Stahmann ,  Pramodsingh Hirasingh Thakur ,  Keith R. Maile

IPC: A61N1/365 ,  A61N1/05 ,  A61N1/375

CPC classification number: A61N1/36585 ,  A61N1/056 ,  A61N1/36535 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/37512 ,  A61N1/3756

Abstract: A leadless cardiac pacemaker (LCP) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The LCP MAY include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart. A controller is disposed within the housing and is operably coupled to the first electrode and the second electrode such that the controller is capable of receiving, via the first electrode and the second electrode, electrical cardiac signals of the heart. The LCP may include a pressure sensor and/or an accelerometer. The controller may determine a pace time within a cardiac cycle based at least in part upon an indication of metabolic demand.

公开(公告)号：US20180020983A1

公开(公告)日：2018-01-25

申请号：US15654838

申请日：2017-07-20

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Yinghong Yu ,  Jeffrey E. Stahmann ,  Pramodsingh Hirasingh Thakur ,  Michael J. Kane

IPC: A61B5/00 ,  A61B5/021 ,  A61B5/0285

CPC classification number: A61B5/6843 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0285 ,  A61B5/686 ,  A61B7/00 ,  A61B7/003 ,  A61B7/04 ,  A61B2562/0247

Abstract: This document discusses, among other things, using a pressure sensor to detect body sound information of a patient, such as cardiac murmurs, respiratory sounds, etc.

公开(公告)号：US20170347968A1

公开(公告)日：2017-12-07

申请号：US15603772

申请日：2017-05-24

Applicant: Cardiac Pacemakers, Inc.

Inventor： Keith R. Maile ,  Pramodsingh Hirasingh Thakur ,  Michael J. Kane ,  Bin Mi ,  Ron A. Balczewski ,  Jeffrey E. Stahmann

IPC: A61B5/00 ,  A61B5/08 ,  A61B7/00 ,  A61B7/04 ,  A61B7/02

CPC classification number: A61B5/7282 ,  A61B5/0022 ,  A61B5/08 ,  A61B5/4836 ,  A61B5/7246 ,  A61B5/7264 ,  A61B7/003 ,  A61B7/023 ,  A61B7/04 ,  A61B2562/0219 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36514

Abstract: Systems and methods for monitoring patients with respiratory diseases are described. A system may include a sensor circuit configured to sense one or more physiological signals indicative of respiratory sounds, and a spectral analyzer to generate first and second spectral contents at respective first and second frequency bands. The system may produce a respiratory anomaly indicator using the first and second spectral contents, or additionally with other physiological parameters. The system may detect an onset or progression of a target respiratory condition such as asthma or chronic obstructive pulmonary disease using the respiratory anomaly indicator, or to trigger or adjust a therapy.

公开(公告)号：US09814424B2

公开(公告)日：2017-11-14

申请号：US14540623

申请日：2014-11-13

Applicant: Cardiac Pacemakers, Inc.

Inventor： Yi Zhang ,  Pramodsingh Hirasingh Thakur ,  Kenneth C. Beck ,  Bryan Allen Clark

IPC: A61B5/0452 ,  A61B5/053 ,  A61B5/08 ,  A61B5/091 ,  A61B7/04 ,  A61M5/172 ,  A61N1/365 ,  A61B5/021 ,  A61B5/00 ,  A61B5/1455 ,  G06F19/00 ,  A61B5/145 ,  A61B5/0245

CPC classification number: A61B5/4848 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/082 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/14552 ,  A61B5/7275 ,  A61B7/04 ,  A61M5/172 ,  A61N1/365 ,  G06F19/00 ,  G06F19/34 ,  G06F19/3462

Abstract: A system may include a port, at least one sensing circuit, and at least one processor. The port is configured to receive an indication of dosing of medication to treat a pulmonary condition of a heart failure (HF) subject and the at least one sensing circuit configured to sense at least one physiological signal, wherein the physiological signal includes physiological information of the HF subject. The at least one processor includes a parameter module configured to extract values of at least one physiological parameter indicative of health status of the HF subject, and a trending module configured to trend extracted values of the at least one physiological parameter and detect an effect of the dosing of the medication on the HF subject using the trending of the extracted values of the at least one physiological parameter.

公开(公告)号：US20170281099A1

公开(公告)日：2017-10-05

申请号：US15473190

申请日：2017-03-29

Applicant: Cardiac Pacemakers, Inc.

Inventor： Viktoria A. Averina ,  Julie A. Thompson ,  Pramodsingh Hirasingh Thakur ,  Qi An ,  Yi Zhang

IPC: A61B5/00 ,  G08B29/22 ,  G08B21/04 ,  A61B5/042 ,  A61B5/04

CPC classification number: A61B5/746 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7282 ,  A61B2505/03 ,  A61B2505/07 ,  G06F19/00 ,  G08B21/0453 ,  G08B29/22

Abstract: Systems, devices, and methods for managing alerts associated with a target physiological event such as a worsening heart failure event are described. A system may detect one or more alert onsets using an onset threshold, and one or more corresponding alert terminations using a reset threshold. Alerts may be issued corresponding to the detected alert onsets and alert terminations. The system may compare the alerts to a specified alert characteristic, and iteratively adjust the onset or reset threshold until the alerts corresponding to the adjusted onset or reset threshold satisfy the specified alert characteristic. The adjusted onset and reset thresholds may be presented to a user or a process for detecting the target physiological event.

公开(公告)号：US20170281096A1

公开(公告)日：2017-10-05

申请号：US15472445

申请日：2017-03-29

Applicant: Cardiac Pacemakers, Inc.

Inventor： Yi Zhang ,  Pramodsingh Hirasingh Thakur ,  Viktoria A. Averina ,  Julie A. Thompson ,  Qi An ,  Jonathan Walter Krueger

IPC: A61B5/00 ,  A61N1/365 ,  A61N1/39 ,  A61B5/0402 ,  A61B5/11

CPC classification number: A61B5/7275 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/4836 ,  A61B5/7253 ,  A61N1/365 ,  A61N1/3956 ,  A61N1/3987 ,  G06F19/00 ,  G06F19/325 ,  G16H40/63 ,  G16H50/20

Abstract: Systems and methods for detecting a target cardiac condition such as events indicative of worsening heart failure are described. A system may include sensor circuits for sensing physiological signals and a signal processor for generating a predictor trend indicative of temporal change of the physiological signal. The predictor trend may be transformed into a sequence of transformed indices using a codebook that includes a plurality of threshold pairs each including onset and reset thresholds. The codebook may be constructed and updated using physiological data. The system may detect target cardiac condition using the transformed indices.

公开(公告)号：US20170281095A1

公开(公告)日：2017-10-05

申请号：US15471583

申请日：2017-03-28

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Pramodsingh Hirasingh Thakur ,  Viktoria A. Averina ,  Julie A. Thompson

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/20 ,  A61B5/02

CPC classification number: A61B5/7275 ,  A61B5/0022 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/201 ,  A61B5/746 ,  A61B2505/07 ,  G16H20/10 ,  G16H40/63 ,  G16H50/30

Abstract: Systems and methods for monitoring patients with multiple chronic diseases are described. A system may include a health status monitor that receives diagnostic data including physiological signals sensed from a patient. The system may produce at least a first risk indication of the patient developing a first disease and a second risk indication of the patient developing a different second disease. The system may detect the first and second diseases from the physiological signals, and generate a composite health status indicator using the detections of the first and second diseases and the first and second risk indications. An alert of worsening health status may be generated if the composite detection score exceeds an alert threshold.

公开(公告)号：US20170215809A1

公开(公告)日：2017-08-03

申请号：US15490226

申请日：2017-04-18

Applicant: Cardiac Pacemakers, Inc.

Inventor： Yi Zhang ,  Pramodsingh Hirasingh Thakur ,  Qi An ,  Julie A. Thompson ,  Ramesh Wariar ,  Robert J. Sweeney

IPC: A61B5/00 ,  A61B7/00

CPC classification number: A61B5/7275 ,  A61B5/0205 ,  A61B5/4842 ,  A61B5/686 ,  A61B7/00 ,  A61B7/04 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

Abstract: Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event.