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公开(公告)号：US20170321208A1
公开(公告)日：2017-11-09
申请号：US15586116
申请日：2017-05-03
发明人： Bart Lipkens , Walter M. Presz, JR. , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Chris Leidel , Louis Masi , Goutam Ghoshal
摘要： Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
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公开(公告)号：US09745548B2
公开(公告)日：2017-08-29
申请号：US15420073
申请日：2017-01-30
发明人： Bart Lipkens , Rudolf Gilmanshin , Louis Masi , Benjamin Ross-Johnsrud , Erik Miller , Walter M. Presz, Jr. , Thomas J. Kennedy, III
IPC分类号： B01D37/00 , C12M1/00 , B01D21/28 , C12M1/34 , G10K15/04 , G10K9/122 , C12M1/26 , C12N13/00 , C07K1/14
CPC分类号： C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C07K1/14 , C12M29/10 , C12M29/18 , C12M33/08 , C12M35/04 , C12M41/12 , C12M47/10 , C12N13/00 , G10K9/122 , G10K15/00 , G10K15/043
摘要： Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.
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公开(公告)号：US09675902B2
公开(公告)日：2017-06-13
申请号：US15000573
申请日：2016-01-19
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
CPC分类号： B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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公开(公告)号：US09567559B2
公开(公告)日：2017-02-14
申请号：US15238624
申请日：2016-08-16
发明人： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC分类号： C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
摘要翻译： 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
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公开(公告)号：US20170029802A1
公开(公告)日：2017-02-02
申请号：US15222800
申请日：2016-07-28
CPC分类号： C12N13/00 , A61K2039/545 , C07K16/2851 , C12M35/04 , C12M47/02 , G01N30/462 , G01N30/72 , G01N30/96 , G01N33/54313 , G01N2030/027
摘要： Methods and systems for separating a first biomaterial from a second biomaterial can use functionalized material retained in a liquid-filled chamber at locales within an acoustic standing wave field. A culture suspension containing the first biomaterial and the second biomaterial flows into the liquid-filled chamber and at least portions of the first biomaterial with features complementary to the functionalized material becomes bound to the functionalized material while other portions of the culture suspension containing the second material pass through the chamber. The portion of the first biomaterial bound to the functionalized material is subsequently released from the liquid filled chamber.
摘要翻译： 用于从第二生物材料分离第一生物材料的方法和系统可以使用保持在充满液体的腔室中的功能化材料在声驻波场内的区域。 包含第一生物材料和第二生物材料的培养悬浮液流入液体填充的室，并且具有与官能化材料互补的特征的第一生物材料的至少部分变得与官能化材料结合，而含有第二材料的培养悬浮液的其它部分 通过房间。 与功能化材料结合的第一生物材料的部分随后从充满液体的室中释放。
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公开(公告)号：US09422328B2
公开(公告)日：2016-08-23
申请号：US14329723
申请日：2014-07-11
CPC分类号： C07K1/145 , B01D17/04 , B01D17/044 , B01D17/06 , B01D21/283 , B01D43/00 , B06B1/0622 , C12M29/04 , C12M35/02 , C12M35/04 , C12M47/10
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
摘要翻译： 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当的位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。
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公开(公告)号：US20160129370A1
公开(公告)日：2016-05-12
申请号：US15000573
申请日：2016-01-19
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, JR. , Thomas J. Kennedy, III , Louis Masi
IPC分类号： B01D17/04
CPC分类号： B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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