公开(公告)号：US20050173287A1

公开(公告)日：2005-08-11

申请号：US11101932

申请日：2005-04-08

申请人： Stephen Smith ,  Kevin Smith ,  Warren Wiedmeyer ,  Kimberly Healy ,  Randy Golden ,  Rudy DesChamps ,  Irshad Khan ,  Bryce Rutter ,  Brian Bone ,  John Loudenslager ,  Jan Stillerman

发明人： Stephen Smith ,  Kevin Smith ,  Warren Wiedmeyer ,  Kimberly Healy ,  Randy Golden ,  Rudy DesChamps ,  Irshad Khan ,  Bryce Rutter ,  Brian Bone ,  John Loudenslager ,  Jan Stillerman

IPC分类号： B65D1/26 ,  B65D1/46 ,  B65D8/12 ,  B65D21/00

CPC分类号： B65D1/265 ,  B65D1/46

摘要： A container is disclosed, generally having an open top defined by an annular rim, a base, and a sidewall extending between the top and the base. The sidewall has two arcuately formed longitudinal recesses, an annular rib, an annular shoulder located between the longitudinal recesses and the base, and a lower portion extending between the annular shoulder and the base. The annular shoulder is characterized by two arched portions aligned with the longitudinal recesses, and the lower portion has two beveled portions aligned with the longitudinal recesses. This container is more ergonomic, and has greater sidewall strength and rigidity, than existing containers.

摘要翻译： 公开了一种容器，其通常具有由环形边缘，基部和在顶部和底部之间延伸的侧壁限定的开口顶部。 侧壁具有两个弧形形成的纵向凹槽，环形肋，位于纵向凹槽和基部之间的环形肩部，以及在环形肩部和基部之间延伸的下部。 环形肩部的特征在于与纵向凹部对准的两个拱形部分，下部具有与纵向凹部对准的两个斜切部分。 该容器比现有的容器更符合人体工程学，并且具有更大的侧壁强度和刚性。

公开(公告)号：US06914128B1

公开(公告)日：2005-07-05

申请号：US09534717

申请日：2000-03-24

申请人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Thor Las Holtet ,  Sarah Leila Du Fou ,  Stephen Smith

发明人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Thor Las Holtet ,  Sarah Leila Du Fou ,  Stephen Smith

IPC分类号： C07K16/24 ,  C07K16/18 ,  C12P21/08

CPC分类号： C07K16/244 ,  A61K9/0019 ,  A61K38/208 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/505 ,  C07K14/5434 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886

摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

公开(公告)号：US20050142269A1

公开(公告)日：2005-06-30

申请号：US11062607

申请日：2005-02-22

申请人： Simon Scullion ,  Peter Foster ,  Stephen Smith

发明人： Simon Scullion ,  Peter Foster ,  Stephen Smith

IPC分类号： B67D1/00 ,  B67D1/04 ,  B67D1/06 ,  B67D1/08 ,  B67D1/14 ,  C12H1/16 ,  C12H1/18 ,  B67D5/62 ,  A23C3/00 ,  A23L3/36 ,  C12C7/26 ,  F25D3/08

CPC分类号： B67D1/0857 ,  B67D1/06 ,  B67D1/0867 ,  B67D1/0869 ,  B67D1/0872 ,  B67D1/1275 ,  B67D1/1411 ,  B67D2001/0487 ,  B67D2210/00104 ,  C12H1/16 ,  C12H1/18

摘要： A method of keeping an alcoholic beverage in an open topped vessel cool, said beverage comprising a water content and a dissolved gas content, and said method comprising forming ice in the beverage in the open-topped vessel said ice having a cooling effect on the beverage, said ice being formed in the beverage from water of said water content.

摘要翻译： 将酒精饮料保持在开放顶部容器中的方法冷却，所述饮料包含含水量和溶解气体含量，并且所述方法包括在开放顶部容器中在饮料中形成冰，所述冰对饮料具有冷却作用 所述冰由所述水分的水形成在饮料中。

公开(公告)号：US20050127075A1

公开(公告)日：2005-06-16

申请号：US10954827

申请日：2004-09-30

申请人： Stephen Smith ,  Warren Wiedmeyer ,  Richard Chin ,  John Gitschlag ,  David Langelan ,  Kevin Smith ,  Richard Sandusky ,  Ayberk Abayhan ,  Masahiko Ishimitsu

发明人： Stephen Smith ,  Warren Wiedmeyer ,  Richard Chin ,  John Gitschlag ,  David Langelan ,  Kevin Smith ,  Richard Sandusky ,  Ayberk Abayhan ,  Masahiko Ishimitsu

IPC分类号： B65D43/02 ,  B65D47/26 ,  B65D55/02 ,  B65D51/18 ,  A47G19/22

CPC分类号： B65D47/265 ,  B65D17/506 ,  B65D43/0212 ,  B65D47/06 ,  B65D47/26 ,  B65D47/286 ,  B65D55/024 ,  B65D2543/00046 ,  B65D2543/00092 ,  B65D2543/00296 ,  B65D2543/00351 ,  B65D2543/00379 ,  B65D2543/00527 ,  B65D2543/00537 ,  B65D2543/00638 ,  B65D2543/00685 ,  B65D2543/00731 ,  B65D2543/00805 ,  B65D2543/00842

摘要： A reclosable lid (10) for a container holding a flowable substance has a cover (12) having an opening (28) and a moveable element (850) connected to the cover (12). The moveable element (850) is moveable between at least one open position, wherein the flowable substance may flow through the opening, and at least one closed position, wherein the opening is obstructed. In some embodiments, the lid (10) may include an overlay (250) moveable between at least one open position and at least one closed position.

摘要翻译： 用于容纳可流动物质的容器的可再闭合盖（10）具有盖（12），其具有连接到盖（12）的开口（28）和可移动元件（850）。 可移动元件（850）可在至少一个打开位置之间移动，其中可流动物质可流过开口，以及至少一个关闭位置，其中开口被阻挡。 在一些实施例中，盖（10）可以包括可在至少一个打开位置和至少一个关闭位置之间移动的覆盖物（250）。

公开(公告)号：US20050115975A1

公开(公告)日：2005-06-02

申请号：US10982187

申请日：2004-11-04

申请人： Stephen Smith ,  Warren Wiedmeyer ,  Ayberk Abayhan ,  Anthony Kreml ,  Alvin Hartman ,  Semyon Bekker ,  Greg Neal ,  Robert Schaefer ,  Robert Scheele ,  Dennis Martin

发明人： Stephen Smith ,  Warren Wiedmeyer ,  Ayberk Abayhan ,  Anthony Kreml ,  Alvin Hartman ,  Semyon Bekker ,  Greg Neal ,  Robert Schaefer ,  Robert Scheele ,  Dennis Martin

IPC分类号： B65D81/38 ,  B31B1/28

CPC分类号： B65D81/3874

摘要： The present invention generally provides an insulating vessel for beverages. The vessel has an outsert and a insert. The insert is positioned within the cavity of the outsert. In one embodiment the insert has a plurality of insulating members that are spaced from an inner surface of the outsert to define a series of air gaps between an outer surface of the insulating members and the inner surface of the outsert. In another embodiment, the insert and outsert have generally conical side walls with substantially the same taper angle so as to be in a friction lock relationship with one another.

摘要翻译： 本发明通常提供一种用于饮料的绝缘容器。 船舶有一个外插和插入。 插入件位于外插的腔内。 在一个实施例中，插入件具有多个绝缘构件，其与外插件的内表面间隔开，以在绝缘构件的外表面和外插件的内表面之间限定一系列气隙。 在另一个实施例中，插入件和外插件具有基本上具有相同锥角的锥形侧壁，以便彼此处于摩擦锁定关系。

公开(公告)号：US20050102223A1

公开(公告)日：2005-05-12

申请号：US10704533

申请日：2003-11-07

申请人： Kenneth Vlazny ,  Joseph Tracy ,  Victor Harrison ,  Jeffery Murphy ,  Stephen Smith

发明人： Kenneth Vlazny ,  Joseph Tracy ,  Victor Harrison ,  Jeffery Murphy ,  Stephen Smith

IPC分类号： G06Q50/00 ,  G07F17/32 ,  G06F17/60

CPC分类号： G06Q50/34 ,  G06Q40/025 ,  G06Q40/04 ,  G07F17/32 ,  G07F17/3288

摘要： The present invention contemplates methods and systems of conducting wagers, such as pari-mutuel wagers. In one exemplary embodiment an event, such as a horse race, dog race, a combination of races, etc., is identified for which a plurality of bettors may each place at least one wager. Each bettor of the plurality is enabled to provide input regarding at least one portion of their respective at least one wager prior to the event. At least one other portion of each bettor's at least one wager is randomized prior to the event. The wager then comprises the combination of the bettor selected portion and randomized portion. In one exemplary embodiment, the player selected portion may include selecting bettor-preferred participants of the event while the randomly selected portion may include the randomly assigning a finishing order to the player selected participants.

摘要翻译： 本发明考虑了进行下注的方法和系统，例如同伴投注。 在一个示例性实施例中，识别诸如赛马，狗赛，种族的组合等的事件，其中多个投注者可以各自投放至少一个下注。 在事件之前，多个的每个下注者能够提供关于它们各自的至少一个下注的至少一部分的输入。 每个投注者的至少一个赌注的至少一个其他部分在事件之前被随机化。 赌注然后包括投注者选择部分和随机化部分的组合。 在一个示例性实施例中，玩家选择的部分可以包括选择事件的优先参与者，而随机选择的部分可以包括随机地向玩家选择的参与者分配完成顺序。

公开(公告)号：US20050098152A1

公开(公告)日：2005-05-12

申请号：US11014921

申请日：2004-12-17

申请人： Gopichandra Surnilla ,  Hans Gangwar ,  Stephen Smith

发明人： Gopichandra Surnilla ,  Hans Gangwar ,  Stephen Smith

IPC分类号： F01N3/08 ,  F01N11/00 ,  F01N13/00 ,  F01N13/10 ,  F02D13/02 ,  F02D31/00 ,  F02D37/02 ,  F02D41/00 ,  F02D41/08 ,  F02D41/14 ,  F02D41/36 ,  F02M25/07 ,  F02M63/02 ,  F02M69/04 ,  F02D41/16

CPC分类号： F02M69/044 ,  F01N3/0814 ,  F01N3/0842 ,  F01N11/002 ,  F01N13/009 ,  F01N13/0093 ,  F01N13/011 ,  F01N13/107 ,  F01N2560/025 ,  F01N2560/026 ,  F01N2560/14 ,  F02D13/0219 ,  F02D31/001 ,  F02D37/02 ,  F02D41/0087 ,  F02D41/08 ,  F02D41/1456 ,  F02D41/1475 ,  F02M26/01 ,  F02M26/13 ,  F02M63/0225

摘要： A method is presented for idle speed control of a lean burn spark ignition internal combustion engine using a fuel-based control strategy. In particular, the idle speed control strategy involves using a combination of fuel quantity or timing and ignition timing to achieve desired engine speed or torque while maintaining the air/fuel ratio more lean than prior art systems. Depending on engine operating conditions, the fuel quantity or timing is adjusted to give a more rich air/fuel ratio in order to respond to an engine speed or torque demand increase. Additionally, due to operation close to the lean misfire limit, the spark ignition timing is adjusted away from MBT in response to an engine speed or torque demand decrease. The advantages of this fuel based control system include better fuel economy as well as fast engine response time due to the use of fuel quantity or timing and ignition timing to control engine output.

摘要翻译： 提出了一种使用基于燃料的控制策略对稀燃火花点火内燃机的怠速控制的方法。 特别地，怠速控制策略涉及使用燃料量或定时和点火正时的组合来实现期望的发动机速度或转矩，同时保持空气/燃料比比现有技术系统更为稀薄。 根据发动机工作条件，调节燃油量或时间以提供更丰富的空气/燃料比，以应对发动机转速或转矩需求增加。 此外，由于接近稀缺失火极限的操作，响应于发动机转速或转矩需求减小，火花点火正时从MBT调节。 基于燃料的控制系统的优点包括由于使用燃料量或定时和点火正时来控制发动机输出而具有更好的燃料经济性和快速的发动机响应时间。

公开(公告)号：US20050061821A1

公开(公告)日：2005-03-24

申请号：US10676807

申请日：2003-10-01

申请人： Stephen Smith ,  Kevin Smith ,  Warren Wiedmeyer ,  Kimberly Healy ,  Randy Golden ,  Rudy DesChamps ,  Irshad Khan ,  Bryce Rutter ,  Brian Bone ,  John Loudenslager ,  Jan Stillerman

发明人： Stephen Smith ,  Kevin Smith ,  Warren Wiedmeyer ,  Kimberly Healy ,  Randy Golden ,  Rudy DesChamps ,  Irshad Khan ,  Bryce Rutter ,  Brian Bone ,  John Loudenslager ,  Jan Stillerman

IPC分类号： B65D1/26 ,  B65D1/46 ,  B65D8/12 ,  B65D6/08

CPC分类号： B65D1/265 ,  B65D1/46

摘要： A container is disclosed, generally having an open top defined by an annular rim, a base, and a sidewall extending between the top and the base. The sidewall has two arcuately formed longitudinal recesses, an annular rib, an annular shoulder located between the longitudinal recesses and the base, and a lower portion extending between the annular shoulder and the base. The annular shoulder is characterized by two arched portions aligned with the longitudinal recesses, and the lower portion has two beveled portions aligned with the longitudinal recesses. This container is more ergonomic, and has greater sidewall strength and rigidity, than existing containers.

公开(公告)号：US20050035124A1

公开(公告)日：2005-02-17

申请号：US10641498

申请日：2003-08-15

申请人： Stephen Smith ,  Dawn Huston ,  Warren Wiedmeyer ,  Stephen Sullivan ,  Rich Chin ,  Mohammed Ahmed ,  John Gitschlag ,  David Langelan ,  Rajendra Chauhan ,  William Hurst ,  James Joines ,  Kevin Smith ,  Mark Anhalt ,  Brian Clarke

发明人： Stephen Smith ,  Dawn Huston ,  Warren Wiedmeyer ,  Stephen Sullivan ,  Rich Chin ,  Mohammed Ahmed ,  John Gitschlag ,  David Langelan ,  Rajendra Chauhan ,  William Hurst ,  James Joines ,  Kevin Smith ,  Mark Anhalt ,  Brian Clarke

IPC分类号： B65D43/02 ,  B65D47/14 ,  A47G19/22 ,  B65D51/18

CPC分类号： B65D47/141 ,  B65D43/0212 ,  B65D2543/00046 ,  B65D2543/00092 ,  B65D2543/00296 ,  B65D2543/00351 ,  B65D2543/00527 ,  B65D2543/00537 ,  B65D2543/00731 ,  B65D2543/00796

摘要： A lid for a container holding a flowable substance has an annular top wall. A side wall depends from the top wall, and has a mounting portion for connecting the lid on the container. The top wall has an opening that is adapted to permit the flow of the substance through the lid. The top wall also has a retaining member. The lid further has a closure member positioned on the mounting portion. The closure member is movable between a first position and a second position, wherein at least a portion of the closure member is received in the opening in the first position and at least a portion of the closure member is received in the retaining member in the second position. The opening and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the opening. The retaining member and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the retaining member. The closure member has a flexible connector arm which facilitates movement of the closure member between the first and second positions.

摘要翻译： 用于容纳可流动物质的容器的盖具有环形顶壁。 侧壁取决于顶壁，并且具有用于连接容器上的盖子的安装部分。 顶壁具有适于允许物质流过盖的开口。 顶壁还具有保持构件。 盖子还具有定位在安装部分上的封闭构件。 闭合构件可在第一位置和第二位置之间移动，其中闭合构件的至少一部分在第一位置处容纳在开口中，并且闭合构件的至少一部分容纳在第二位置中的保持构件中 位置。 开口和关闭构件协调地确定尺寸，使得封闭构件可拆卸地插入开口中。 保持构件和封闭构件协调地确定尺寸，使得封闭构件可移除地插入保持构件中。 封闭构件具有柔性连接臂，其有助于封闭构件在第一和第二位置之间移动。

公开(公告)号：US5700691A

公开(公告)日：1997-12-23

申请号：US707762

申请日：1996-09-13

申请人： James G. Bender ,  Phillip B. Maples ,  Stephen Smith ,  Kristen L. Unverzagt ,  Dennis E. Van Epps

发明人： James G. Bender ,  Phillip B. Maples ,  Stephen Smith ,  Kristen L. Unverzagt ,  Dennis E. Van Epps

IPC分类号： A61K35/12 ,  A61K35/14 ,  A61K35/15 ,  A61K35/28 ,  A61K39/00 ,  A61K48/00 ,  A61P7/00 ,  C12N5/0787 ,  A01N63/00 ,  C12N5/00 ,  C12N5/02

CPC分类号： A61K35/15 ,  C12N5/0642 ,  A61K2039/5156 ,  A61K48/00 ,  C12N2500/44 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/39

摘要： A composition of human neutrophil precursor cells is disclosed wherein at least 16% of the cells are human myeloblasts and promyelocytes. The myeloblasts and promyelocytes are derived from human neutrophil progenitor cells that were obtained from peripheral blood, bone marrow or cord blood. The neutrophil precursor cells contain less than 5% colony forming units. Also disclosed are human neutrophil precursor cells made up of about 16% CD15+CD11b- cells and less than 5% colony forming units and methods of preparing these compositions.

摘要翻译： 公开了人嗜中性粒细胞前体细胞的组合物，其中至少16％的细胞是人类成髓细胞和前髓细胞。 成髓细胞和前髓细胞衍生自从外周血，骨髓或脐带血获得的人嗜中性粒细胞祖细胞。 中性粒细胞前体细胞含有小于5％的集落形成单位。 还公开了由约16％CD15 + CD11b-细胞和小于5％集落形成单位组成的人嗜中性粒细胞前体细胞和制备这些组合物的方法。