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    Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration
    32.
    发明授权
    Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration 失效
    含有二氮芥酸介质的电化学生物传感器用于辅酶再生

    公开(公告)号：US5866353A

    公开(公告)日：1999-02-02

    申请号：US762098

    申请日：1996-12-09

    Applicant: Horst Berneth ,  Thomas Bocker ,  Henry Giera ,  Alison J. Murray ,  Hans-Ulrich Siegmund

    Inventor： Horst Berneth ,  Thomas Bocker ,  Henry Giera ,  Alison J. Murray ,  Hans-Ulrich Siegmund

    IPC: G01N27/327 ,  C12Q1/00 ,  C12Q1/32 ,  C09B44/10 ,  C12M1/00 ,  G01N27/26

    CPC classification number: C12Q1/004 ,  Y10S435/817

    Abstract: A variety of diazacyanine mediators that are soluble in aqueous media and which do not inhibit enzymatic activity are provided for use on the surface of a working electrode of a electrochemical biosensor for electrochemical co-enzyme regeneration. The co-enzyme, dihydronicotinamide adenine dinucleotide (NADH) or dihydronicotinamide adenine dinucleotide phosphate (NADPH), is oxidized to NAD.sup.+ OR NADP.sup.+ which is reduced by an oxidoreductase such as a dehydrogenase acting on a substrate. By applying the mediator together with NADH or NADPH to the surface of the working electrode, the voltage necessary to achieve oxidation is substantially reduced. Biosensor electrodes such as graphite electrodes may be produced-by screen printing techniques.

    Abstract translation: 提供了可溶于水性介质并且不抑制酶活性的各种二氮芥酸介质用于电化学生物传感器用于电化学辅酶再生的工作电极的表面。 辅酶，二氢烟酰胺腺嘌呤二核苷酸（NADH）或二氢烟酰胺腺嘌呤二核苷酸磷酸（NADPH）被氧化成NAD + OR NADP +，其由氧化还原酶例如作用于底物的脱氢酶而还原。 通过将介体与NADH或NADPH一起施加到工作电极的表面，实现氧化所需的电压显着降低。 生物传感器电极如石墨电极可以通过丝网印刷技术制造。

    Recording material comprising chromogenic 3,1-benzoxazines
    35.
    发明授权
    Recording material comprising chromogenic 3,1-benzoxazines 失效
    包含显色3,1-苯并恶嗪的记录材料

    公开(公告)号：US4904637A

    公开(公告)日：1990-02-27

    申请号：US311002

    申请日：1989-02-14

    Applicant: Horst Berneth

    Inventor： Horst Berneth

    IPC: B41M5/136 ,  B41M5/323 ,  C07D265/16 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C09B11/02 ,  C09B11/04 ,  C09B19/00 ,  G02F1/17

    CPC classification number: C09B11/04 ,  B41M5/136 ,  B41M5/323 ,  C07D265/16 ,  C07D413/04 ,  C09B11/02

    Abstract: Compounds of the formula ##STR1## wherein Z.sup.1 denotes hydrogen, alkyl, cycloalkyl or ##STR2## R.sup.1 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl, heteroalkyl or heteryl,X.sup.1, X.sup.2 and X.sup.3 denote hydrogen, halogen, alkyl, cycloalkyl, aryl, alkanoylamino, aroylamino or heteryl, and at least one of these radicals denotes NH.sup.1 Y.sup.2, OY.sup.3 or SY.sup.3,Y.sup.1, Y.sup.2 and Y.sup.3 denote hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heteryl andY.sup.1 +Y.sup.2 denote the remaining members of a 5-membered or 6-membered ring which optionally contains further hetero-atoms,are outstanding suitable as color-forming agents for pressure-sensitive, heat-sensitive and electrosensitive recording materials with an acid developer. Deep copies which are fast to light are obtained.

    Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and their use
    36.
    发明授权
    Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and their use 失效
    显色的4,4-二芳基 - 二氢喹唑啉酮，其制备及其应用

    公开(公告)号：US4695633A

    公开(公告)日：1987-09-22

    申请号：US735477

    申请日：1985-05-17

    Applicant: Horst Berneth ,  Alfred Brack

    Inventor： Horst Berneth ,  Alfred Brack

    IPC: B41M5/136 ,  A01N43/54 ,  B41M5/145 ,  B41M5/327 ,  C07D239/42 ,  C07D239/47 ,  C07D239/82 ,  C07D401/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C09B11/04

    CPC classification number: C09B11/04 ,  B41M5/145 ,  B41M5/327

    Abstract: Chromogenic 4,4-diaryl-dihydroquinazolones of the formula ##STR1## wherein X.sup.1, X.sup.2 and X.sup.3 independently of one another represent hydrogen, halogen, alkyl, aryl, alkanoylamino, aroylamino, NY.sup.1 Y.sup.2, OY.sup.3 or SY.sup.3,and whereinat least one of the radicals X.sup.1, X.sup.2 or X.sup.3 represents NY.sup.1 Y.sup.2, OY.sup.3 or SY.sup.3,R.sup.1 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl or the members of a bridge to the o-carbon of ring C,R.sup.2 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl, hetaralkyl or hetaryl,Y.sup.1, Y.sup.2 and Y.sup.3 independently of one another denote hydrogen, alkyl, cycloalkyl, aralkyl or aryl or the remaining members of a 5-membered or 6-membered ring which reaches to one of the benzene-C atoms in the o-position and optionally contains further hetero-atoms, orY.sup.1 +Y.sup.2 denote the remaining members of a 5-membered or 6-membered ring which optionally contains further hetero-atoms, andthe rings A, B and C and the radicals mentioned can in turn carry non-ionic substituents customary in dyestuff chemistry, are used in pressure-sensitive and thermoreactive recording materials.

    Abstract translation: 式（I）的显色4,4-二芳基 - 二氢喹唑啉酮其中X1，X2和X3彼此独立地表示氢，卤素，烷基，芳基，烷酰基氨基，芳酰氨基，NY1Y2，OY3或SY3，并且其中至少 基团X1，X2或X3中的一个表示NY1Y2，OY3或SY3，R1表示氢，烷基，环烷基，芳烷基，芳基或与环C的邻碳键桥的成员，R2表示氢，烷基，环烷基， 芳烷基，芳基，杂芳烷基或杂芳基，Y 1，Y 2和Y 3彼此独立地表示氢，烷基，环烷基，芳烷基或芳基或5员或6元环的剩余成员，其达到苯-C 原子位于O位且任选地含有其它杂原子，或Y1 + Y2表示任选含有其它杂原子的5元或6元环的剩余成员，并且环A，B和C以及 所提及的自由基可以依次携带染料化学中常规的非离子取代基，用于 压敏和热反应性记录材料。

    Homopolymers which exhibit a high level of photo-inducable birefringence
    39.
    发明授权
    Homopolymers which exhibit a high level of photo-inducable birefringence 有权
    表现出高水平的可感光双折射的均聚物

    公开(公告)号：US07214752B2

    公开(公告)日：2007-05-08

    申请号：US10998381

    申请日：2004-11-29

    Applicant: Horst Berneth ,  Uwe Claussen ,  Serguei Kostromine ,  Ralf Neigl ,  Hans-Joachim Vedder

    Inventor： Horst Berneth ,  Uwe Claussen ,  Serguei Kostromine ,  Ralf Neigl ,  Hans-Joachim Vedder

    IPC: C08F114/18

    CPC classification number: G11C13/0014 ,  B82Y10/00 ,  C08F120/36 ,  G11B7/244 ,  G11B7/245 ,  G11B7/2467 ,  G11B7/25 ,  G11B7/253 ,  G11C13/0016 ,  G11C13/04 ,  G11C13/042

    Abstract: Homopolymers suitable for storage of information provided optically are disclosed. The are formed from monomers which contain groupings which are at least trinuclear, which are capable of absorbing the electromagnetic radiation of visible light, and which are structured so that in their thermodynamically stable state they are distended and strongly anisometric, wherein the at least trinuclear groupings comprise at least one electron-attracting substituent which gives rise to a dipole moment which forms an angle of at least 20° with the longitudinal axis of the at least trinuclear groupings, wherein the at least trinuclear groupings contain at least one nucleus-linking group which is suitable for a photo-induced change in configuration, wherein said group is selected from the set consisting of

    Abstract translation: 公开了适用于光学存储信息的均聚物。 由含有至少三核的能够吸收可见光的电磁辐射的组的单体形成，并且其结构使得在它们的热力学稳定状态下它们被扩张和强烈的不等轴度，其中至少三核分组 包含至少一个吸电子取代基，其产生与所述至少三核分组的纵轴形成至少20°的角度的偶极矩，其中所述至少三核分组含有至少一个核连接基团， 适合于光诱导的配置变化，其中所述组从由以下组成的组中选择

    Colored buffer solution for automated clinical analyzer
    40.
    发明申请
    Colored buffer solution for automated clinical analyzer 审中-公开
    彩色缓冲溶液，用于自动临床分析仪

    公开(公告)号：US20060172425A1

    公开(公告)日：2006-08-03

    申请号：US11048601

    申请日：2005-02-01

    Applicant: Ralf Neigl ,  Michael Sommer ,  Bronislaw Czech ,  Horst Berneth ,  Alan Toth ,  Josef-Walter Stawitz

    Inventor： Ralf Neigl ,  Michael Sommer ,  Bronislaw Czech ,  Horst Berneth ,  Alan Toth ,  Josef-Walter Stawitz

    IPC: G01N33/00

    CPC classification number: G01N35/08 ,  G01N21/05 ,  G01N21/80 ,  G01N2021/0346 ,  G01N2035/00277 ,  Y10T436/108331

    Abstract: A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.

    Abstract translation: 使用有色的胶囊缓冲溶液来减少在自动化临床分析仪中胶囊化学液体分析系统的分析线中的少量试剂R1和/或R2吸收或携带到胶囊缓冲溶液段中的错误结果。 在胶囊缓冲液溶液中少量摄取R1和/或R2的吸收导致对测试样品S的分析的错误结果，因为携带并吸收到缓冲液中的R1和/或R2不是 与测试样品S反应。可以通过监测着色缓冲溶液的吸光度来测量和确定R1 / R2携带量，其中可以测量吸光度的变化并与参考值进行比较。 如果吸光度发生不可接受的变化，样品将自动重新测试。 有色缓冲溶液包含酞菁染料，pH为约9-12的碱的水溶液，降低表面张力的表面活性剂，并通过分析线改善层间彩色缓冲剂的流动特性，以及螯合剂 减少金属污染物的不利影响。

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