公开(公告)号：US20080294218A1

公开(公告)日：2008-11-27

申请号：US11909786

申请日：2006-03-31

申请人： George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Lawrence W. Arne ,  Olivier Colliou ,  Benedict James Costello ,  Fataneh A. Omidvar

发明人： George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Lawrence W. Arne ,  Olivier Colliou ,  Benedict James Costello ,  Fataneh A. Omidvar

IPC分类号： A61N1/06

CPC分类号： A61N1/3627 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/3686 ,  A61N1/37247

摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.

摘要翻译： 本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。 在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。 起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。 然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。 该系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极发射的起搏信号。

公开(公告)号：US20080097566A1

公开(公告)日：2008-04-24

申请号：US11777981

申请日：2007-07-13

申请人： Olivier Colliou

发明人： Olivier Colliou

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： The present invention provides significantly improved electrode structures, including segmented electrode structures, which are able to deliver highly focused energy to tissue when implanted into a patient. Embodiments of the invention include focused segmented electrodes. Also provided are leads that include the focused segmented electrodes, implantable pulse generators that include the leads, as well as systems and kits having components thereof, and methods of making and using the subject devices.

摘要翻译： 本发明提供了显着改进的电极结构，包括分段电极结构，其能够在植入患者体内时向组织递送高度集中的能量。 本发明的实施例包括聚焦的分段电极。 还提供了包括聚焦的分段电极，包括引线的可植入脉冲发生器以及具有其部件的系统和套件以及制造和使用本发明装置的方法的引线。

公开(公告)号：US20050236277A9

公开(公告)日：2005-10-27

申请号：US10291449

申请日：2002-11-07

申请人： Mir Imran ,  Olivier Colliou ,  Ted Layman ,  Sharon Lake

发明人： Mir Imran ,  Olivier Colliou ,  Ted Layman ,  Sharon Lake

IPC分类号： A61B17/00 ,  A61B17/30 ,  A61B17/34 ,  A61F5/00 ,  A61M25/02 ,  A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  G01N27/12 ,  C25D11/00

CPC分类号： A61B5/6882 ,  A61B5/4238 ,  A61B17/3421 ,  A61B17/3478 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00477 ,  A61B2017/306 ,  A61B2017/3488 ,  A61F5/0003 ,  A61M25/02 ,  A61M2025/0233 ,  A61M2025/028 ,  A61N1/0509 ,  A61N1/0517 ,  A61N1/36007 ,  A61N1/372 ,  G01N27/126 ,  G06F19/00

摘要： A device, system and method for diagnosing and treating gastric disorders is provided. A functional device resides within the patient's stomach and is secured to the stomach wall by an attachment device. The functional device may be a sensor for sensing various parameters of the stomach or stomach environment, or may be a therapeutic delivery device. The functional device in one embodiment provides a device, system and method for gastric electrical stimulation where stimulating electrodes are secured to the wall of the stomach by the attachment device or otherwise. A preferred device includes: at least one stimulating electrode in electrical contact with the stomach wall; an electronics unit containing the electronic circuitry of the device; and an attachment mechanism for attaching the device to the stomach wall. The functional devices may be programmed to respond to sensed information or signals. An endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location.

摘要翻译： 提供了用于诊断和治疗胃疾病的装置，系统和方法。 功能装置位于患者的胃内，并通过附接装置固定到胃壁。 功能装置可以是用于感测胃或胃环境的各种参数的传感器，或者可以是治疗递送装置。 在一个实施例中的功能装置提供了用于胃电刺激的装置，系统和方法，其中刺激电极通过附接装置或其它方式固定到胃壁。 优选的装置包括：与胃壁电接触的至少一个刺激电极; 包含该装置的电子电路的电子单元; 以及用于将装置附接到胃壁的附接机构。 功能设备可以被编程为响应感测的信息或信号。 内窥镜递送系统通过食管将功能装置输送到胃中，在胃附着胃壁。 内窥镜器械将附接装置和功能装置从胃附接或移除，并且可以用于帮助确定最佳的附接位置。

公开(公告)号：US20100280366A1

公开(公告)日：2010-11-04

申请号：US12522537

申请日：2009-05-12

申请人： Lawrence Arne ,  Orlando Banos ,  Yashar Behzadi ,  Olivier Colliou ,  Benedict Costello ,  Robert Leichner ,  Gregory Moon ,  Timothy Robertson ,  George Savage ,  Todd Thompson ,  Mark Zdeblick

发明人： Lawrence Arne ,  Orlando Banos ,  Yashar Behzadi ,  Olivier Colliou ,  Benedict Costello ,  Robert Leichner ,  Gregory Moon ,  Timothy Robertson ,  George Savage ,  Todd Thompson ,  Mark Zdeblick

IPC分类号： A61B5/05

CPC分类号： A61B5/046 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/0422 ,  A61B5/0536 ,  A61B5/0538 ,  A61B5/4519 ,  A61B5/743 ,  A61B5/7435 ,  A61B6/503 ,  A61B8/0883

摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.

摘要翻译： 提供连续场断层摄影系统。 系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。 还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。 本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

公开(公告)号：US20100239616A1

公开(公告)日：2010-09-23

申请号：US12447172

申请日：2007-10-25

申请人： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou

发明人： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou

IPC分类号： A61K9/00 ,  A61P43/00 ,  H01M6/32

CPC分类号： A61K9/2072 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4238 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/6861 ,  A61B2560/0214 ,  A61J3/007 ,  A61K49/00 ,  H01M10/0436

摘要： Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

摘要翻译： 提供了用于可摄取组合物的受控激活标识符，例如制药信息学组合物。 标识符包括受控激活元件，其响应于感兴趣的目标位置处的预定刺激的存在而提供对标识符的激活。 本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。

公开(公告)号：US20080316020A1

公开(公告)日：2008-12-25

申请号：US12126798

申请日：2008-05-23

申请人： TIMOTHY L. ROBERTSON ,  Olivier Colliou ,  Eric J. Snyder ,  Mark J. Zdeblick

发明人： TIMOTHY L. ROBERTSON ,  Olivier Colliou ,  Eric J. Snyder ,  Mark J. Zdeblick

IPC分类号： H04Q7/00

CPC分类号： A61B5/07 ,  A61B1/00016 ,  A61B1/041 ,  H01Q1/2208 ,  H01Q1/36

摘要： RFID antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include RFID signal transmission antennas with a battery that is activated upon being exposed to fluid in the body. Embodiments of the RFID antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

摘要翻译： 提供了可摄取装置的RFID天线，例如可摄取事件标记。 本发明的可摄取装置的方面包括具有电池的RFID信号传输天线，其在暴露于身体中的流体时被激活。 RFID天线的实施例被配置为在与目标生理部位接触时发出可检测信号。 还提供了制造和使用本发明的装置的方法。

公开(公告)号：US20080306360A1

公开(公告)日：2008-12-11

申请号：US12126792

申请日：2008-05-23

申请人： Timothy L. Robertson ,  Olivier Colliou ,  Eric J. Snyder ,  Mark J. Zdeblick

发明人： Timothy L. Robertson ,  Olivier Colliou ,  Eric J. Snyder ,  Mark J. Zdeblick

IPC分类号： A61B5/07 ,  H01Q1/36

CPC分类号： A61B5/07 ,  A61B1/00016 ,  A61B1/041 ,  H01Q1/2208 ,  H01Q1/36

摘要： Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

摘要翻译： 提供用于可摄取装置的低轮廓天线，例如可摄取事件标记。 本发明的可摄取装置的方面包括配置成在使用后它们是柔性的或降级的低轮廓信号传输天线，允许天线和附接的部件容易地穿过身体。 低轮廓天线的实施例被配置为在与目标生理部位接触时发出可检测信号。 还提供了制造和使用本发明的装置的方法。

公开(公告)号：US20080242976A1

公开(公告)日：2008-10-02

申请号：US11664468

申请日：2007-03-30

申请人： Timothy L. Robertson ,  Olivier Colliou ,  Benedict J. Costello ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick

发明人： Timothy L. Robertson ,  Olivier Colliou ,  Benedict J. Costello ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick

IPC分类号： A61B5/04

CPC分类号： A61B5/1107 ,  A61B5/686 ,  A61B2562/046 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/375 ,  A61N1/3752 ,  A61N1/3756 ,  A61N2001/0585

摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electromechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。 使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US20080058656A1

公开(公告)日：2008-03-06

申请号：US11731786

申请日：2007-03-30

申请人： Benedict Costello ,  Timothy Robertson ,  Mark Zdeblick ,  George Savage ,  Olivier Colliou ,  Todd Thompson

发明人： Benedict Costello ,  Timothy Robertson ,  Mark Zdeblick ,  George Savage ,  Olivier Colliou ,  Todd Thompson

IPC分类号： A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/686 ,  A61B8/08 ,  A61B8/488 ,  A61B2562/046 ,  A61N1/3627

摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via electrical field tomography are provided. In the subject methods, an sensing element is stably associated with a tissue location of interest. Signals obtained from the sensing element are obtained to evaluate movement of the tissue location. Also provided are systems and devices for practicing the subject methods. In addition, innovative data displays and systems for producing the same are provided. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了用于通过电场层析成像评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在本方法中，感测元件与感兴趣的组织位置稳定地相关联。 获得从感测元件获得的信号以评估组织位置的移动。 还提供了用于实践主题方法的系统和设备。 此外，还提供了创新的数据显示和用于生产数据的系统。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US20060293751A1

公开(公告)日：2006-12-28

申请号：US11505783

申请日：2006-08-16

申请人： Jeffrey Lotz ,  Olivier Colliou ,  David Bradford

发明人： Jeffrey Lotz ,  Olivier Colliou ,  David Bradford

IPC分类号： A61F2/44

CPC分类号： B29C41/14 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30069 ,  A61F2002/30133 ,  A61F2002/30957 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4629 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61F2230/0015 ,  A61F2310/00365 ,  A61F2310/0097 ,  A61L27/18 ,  A61L27/58 ,  A61L2430/38 ,  B29C41/42 ,  C08L75/04 ,  C08L71/02

摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.