摘要:
Enabling a relatively fast look up for a rule associated with an arbitrarily selectable IP address. In one embodiment, RSBound objects are sorted into an array where each RSBound object is composed of a bound IP address (BIP), sister BIP, type, index, sister index, and a configured rule. The BIPs are derived from arbitrary user-specified IP addresses or IP address ranges. Each single IP address configuration derives one RSBound entry, where the BIP is the given IP address itself; and each IP range configuration derives two RSBound entries, and the range's lower bound and upper bound are their respective BIPs. The array is sorted primarily based on the RSBound's BIP value, and their type and pair information are the tiebreakers. If a configured rule needs to be searched for a given IP address, a binary search is performed first to find a starting entry, from where a jump-skip search is performed to find the best matching rule for the given IP address. Additionally, although this invention is well suited for IP range matching, it can also be used to match keys with arbitrary ranges of other non-IP address types, e.g., mobile telephone numbers.
摘要:
The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.
摘要:
A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.
摘要:
A process for making an insulating glass assembly is disclosed, the process including applying a sealant composition to a surface of a spacer; contacting the sealant composition with a glass pane, and applying pressure on the glass pane to bond the glass pane to the spacer through the sealant composition, the pressure being applied at an ambient temperature of from about 15° C. to about 60° C.
摘要:
Cytoprotective compounds, many of which are benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要:
Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.
摘要:
New hybrid materials have been prepared by combining a titanium alkoxide sol with high a refractive index phosphine oxide-containing oligomeric component (triethoylsilane-capped poly(arylene ether phosphine oxide). These materials are prepared by the sol-gel method. The final products are transparent and display high refractive index (n.sub.D =1.66-1.80). The refractive index of these hybrid materials display a linear relationship with titanium oxide content.
摘要:
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.
摘要:
Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.
摘要:
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.