利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

251 条记录 (耗时 0.04 秒)

    Glucamine salts for treating hepatitis virus infections
    32.
    发明授权
    Glucamine salts for treating hepatitis virus infections 失效
    用于治疗肝炎病毒感染的葡萄糖胺盐

    公开(公告)号：US06747149B2

    公开(公告)日：2004-06-08

    申请号：US10322045

    申请日：2002-12-17

    申请人： Richard A. Mueller ,  Martin L. Bryant ,  Richard A. Partis

    发明人： Richard A. Mueller ,  Martin L. Bryant ,  Richard A. Partis

    IPC分类号： C07D29522

    CPC分类号： A61K45/06 ,  A61K31/047 ,  A61K31/137 ,  C07C215/10

    摘要： N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.

    摘要翻译： 式I的N-取代的葡糖胺化合物在治疗肝炎感染中是有效的，包括乙型肝炎和丙型肝炎。在治疗肝炎感染中，式I化合物可以单独使用或与另一种选自核苷，核苷酸的抗病毒药物组合使用 ，免疫调节剂，免疫刺激剂或这些其它药剂的各种组合。

    Process for the preparation of glyceraldehyde and derivatives thereof
    35.
    发明申请
    Process for the preparation of glyceraldehyde and derivatives thereof 失效
    甘油醛及其衍生物的制备方法

    公开(公告)号：US20010025124A1

    公开(公告)日：2001-09-27

    申请号：US09793220

    申请日：2001-02-26

    发明人： Ulrich Wecker ,  Manfred Josef Bergfeld

    IPC分类号： C07C047/19

    CPC分类号： C07C41/50 ,  C07C45/511 ,  C07C213/02 ,  C07C407/00 ,  C07C47/19 ,  C07C215/10 ,  C07C43/317 ,  C07C409/20

    摘要： The invention pertains to a process for the preparation of glyceraldehyde, or an acetal or a hemiacetal thereof, characterized in that 3-butene-1,2-diol is dissolved in a lower alkanol and is subjected to ozonolysis to obtain a 3-hydroperoxy-3-alkoxy-propane-1,2-diol, which is subjected to a reductive treatment to obtain a hemiacetal of glyceraldehyde, which optionally may be converted into glyceraldehyde or an acetal or hemiacetal thereof, and to a process wherein the hemiacetal of glyceraldehyde is converted to a 3-aminopropane-1,2-diol derivative, by subjecting the hemiacetal of glyceraldehyde to a reductive treatment in the presence of ammonia or a primary or secondary amine. Preferably, the hemiacetal of glyceraldehyde is subjected to a reductive treatment in the presence of an amine with the formula R1R2NH, wherein R1 and R2 independently are hydrogen or an alkyl group with 1-18 carbon atoms, or R1 and R2 together with the nitrogen atom to which they are bonded form a 5- or 6-membered ring, to give a compound with the formula R1R2NnullCH2nullCHOHnullCH2OH, wherein R1 and R2 have the previously given meanings

    摘要翻译： 本发明涉及制备甘油醛或缩醛或半缩醛的方法，其特征在于将3-丁烯-1,2-二醇溶于低级链烷醇中，进行臭氧分解，得到3-氢过氧基 - 3-烷氧基 - 丙烷-1,2-二醇，其进行还原处理以获得甘油醛的半缩醛，其任选地可以转化成甘油醛或缩醛或半缩醛，并且其中甘油醛的半缩醛是 转化为3-氨基丙烷-1,2-二醇衍生物，通过在氨或伯或仲胺的存在下使甘油醛的半缩醛进行还原处理。 优选地，甘油醛的半缩醛在式R1R2NH的胺存在下进行还原处理，其中R 1和R 2独立地是氢或具有1-18个碳原子的烷基，或者R 1和R 2与氮原子一起 它们被键合形成5-或6-元环，得到具有式R 1 R 2 N-CH 2 -CHOH-CH 2 OH的化合物，其中R 1和R 2具有先前给出的含义

    Process for the preparation of alkanolamines having improved color quality
    36.
    发明授权
    Process for the preparation of alkanolamines having improved color quality 有权
    具有改善颜色质量的烷醇胺的制备方法

    公开(公告)号：US06291715B1

    公开(公告)日：2001-09-18

    申请号：US09643724

    申请日：2000-08-23

    申请人： Günther Ruider ,  Karl-Heinz Ross ,  Boris Breitscheidel ,  Heike Maier ,  Gerhard Schulz ,  Sylvia Huber

    发明人： Günther Ruider ,  Karl-Heinz Ross ,  Boris Breitscheidel ,  Heike Maier ,  Gerhard Schulz ,  Sylvia Huber

    IPC分类号： C07C20984

    CPC分类号： C07C213/10 ,  C07C215/08 ,  C07C215/10 ,  C07C215/14

    摘要： Preparation of alkanolamines having improved color quality by treating the alkanolamine with hydrogen in the presence of a hydrogenation catalyst at elevated temperature, by using, as hydrogenation catalyst, a heterogeneous catalyst comprising Re, Ru, Rh, Pd, Os, Ir, Pt and/or Ag and a support material chosen from the group consisting of activated carbon, alpha-aluminum oxide, zirconium dioxide and titanium dioxide, where the catalyst, in the case of activated carbon as support material, has a cutting hardness of at least 10 N, a side crushing strength of at least 30 N or a compressive strength of at least 25 N.

    摘要翻译： 通过在氢化催化剂存在下，在升高的温度下，用氢处理链烷醇胺，通过使用氢化催化剂，制备包含Re，Ru，Rh，Pd，Os，Ir，Pt和/ 或Ag和选自活性炭，α-氧化铝，二氧化锆和二氧化钛的载体材料，其中在活性炭作为载体材料的情况下，催化剂具有至少10N的切割硬度， 至少30N的侧面抗压强度或至少25N的抗压强度。

    Process and catalyst for synthesizing aliphatic, cyclic and aromatic alkanolamines and alkyleneamines
    37.
    发明授权
    Process and catalyst for synthesizing aliphatic, cyclic and aromatic alkanolamines and alkyleneamines 有权
    用于合成脂族，环状和芳族链烷醇胺和亚烷基胺的方法和催化剂

    公开(公告)号：US06281387B1

    公开(公告)日：2001-08-28

    申请号：US09430634

    申请日：1999-10-29

    申请人： Madan Mohan Bhasin ,  Stephen Wayne King

    发明人： Madan Mohan Bhasin ,  Stephen Wayne King

    IPC分类号： C07C20902

    CPC分类号： C07C213/00 ,  C07C209/02 ,  C07C211/10 ,  C07C215/08 ,  C07C215/10

    摘要： The invention provides a process for synthesizing alkanolamines and/or alkyleneamines by reacting either an alkane, an alkene, or both with a source of oxygen and a source of nitrogen and, optionally, additional hydrogen to convert the alkane and/or alkene by selective partial oxidative amination to at least one of the desired end products. The invention further provides a regenerable catalyst for use in synthesizing alkanolamines and/or alkyleneamines by selective partial oxidative amination of alkanes and/or alkenes.

    摘要翻译： 本发明提供了一种通过使烷烃，烯烃或二者与氧源和氮源和任选的另外的氢反应来将烷烃和/或烯烃转化为选择性部分的烷基醇和/或亚烷基胺的方法 氧化胺化至所需的最终产物中的至少一种。 本发明还提供了一种用于通过烷烃和/或烯烃的选择性部分氧化胺化来合成烷醇胺和/或亚烷基胺的可再生催化剂。

    Sphingosine analogues
    38.
    发明授权
    Sphingosine analogues 失效
    鞘氨醇类似物

    公开(公告)号：US06235912B1

    公开(公告)日：2001-05-22

    申请号：US09380647

    申请日：1999-10-15

    申请人： Kazutoh Takesako ,  Toru Kurome ,  Naoyuki Awazu ,  Ikunoshin Kato

    发明人： Kazutoh Takesako ,  Toru Kurome ,  Naoyuki Awazu ,  Ikunoshin Kato

    IPC分类号： C07C23100

    CPC分类号： C07D307/33 ,  C07C215/10 ,  C07C215/24 ,  C07C229/22 ,  C07C229/30 ,  C07C237/08 ,  C07C237/22 ,  C07C251/08 ,  C07C271/22 ,  C07D263/06 ,  Y02P20/55

    摘要： The present invention aims to provide a novel sphingosine analogue, which is useful as an intermediate for syntheses of novel lipid derivatives such as sphingolipid derivatives and the like that can regulate the effects of sphingolipid. The present invention relates to a sphingosine analogue represented by the general formula (I) described below. In the formula, as for Q1, Q2 and Q3, Q1 and Q2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 of carbon atoms, acyl groups having 2-5 of carbon atoms, or protecting groups of the amino group, and Q3 is a hydrogen or a protecting group of the hydroxyl group; or Q2 and Q3 make up an isopropylidene group and Q1 is a hydrogen or a protecting group of the amino group. Q4 and Q5, which are the same or different each other, are hydroxyl groups, acyl groups having 2-5 of carbon atoms, —O—Q6, or hydrogen; or Q4 and Q5 make up a covalent bond. Q6 is a protecting group of the hydroxyl group. X1 is —COOH, —CONH2, —CO—Q7, —CH2OH, or —CH2O—Q8. Q7 is a protecting group of the carboxyl group, and Q8 is a protecting group of the hydroxyl group.

    摘要翻译： 本发明的目的在于提供一种新颖的鞘氨醇类似物，其可用作合成新型脂质衍生物的中间体，例如可以调节鞘脂的作用的鞘脂衍生物等。本发明涉及一般的鞘氨醇类似物 在该式中，对于Q1，Q2和Q3，Q1和Q2彼此相同或不同，为氢，具有1-4个碳原子的烷基，酰基具有2- 5个碳原子或氨基的保护基，Q3为氢或羟基的保护基; 或Q2和Q3构成异亚丙基，Q 1为氢或氨基的保护基。 Q4和Q5彼此相同或不同，是羟基，具有2-5个碳原子的酰基，-O-Q6或氢; 或Q4和Q5构成共价键。 Q6是羟基的保护基。 X 1是-COOH，-CONH 2，-CO-Q 7，-CH 2 OH或-CH 2 O-Q 8。 Q7是羧基的保护基，Q8是羟基的保护基。

    Highly purified 1-aminopropanediol-2,3
    40.
    发明授权
    Highly purified 1-aminopropanediol-2,3 失效
    高纯度的1-氨基丙二醇-2,3

    公开(公告)号：US5750792A

    公开(公告)日：1998-05-12

    申请号：US761815

    申请日：1996-12-06

    申请人： Hiroshi Koyama ,  Etsuo Takemoto

    发明人： Hiroshi Koyama ,  Etsuo Takemoto

    IPC分类号： C07C213/10 ,  C07C215/10 ,  C07C211/03

    CPC分类号： C07C215/10 ,  C07C213/10

    摘要： 1-aminopropanediol-2,3 containing 2-aminopropanediol-1,3 of less than 0.30% by weight can be prepared by the present purification process, which comprises distilling a l-aminopropanediol-2,3 containing at least 0.3% of 2-aminopropanediol-1,3 based on the weight of 1-aminopropanediol-2,3 with a distillation column, said distillation column having low pressure loss.

    摘要翻译： 可以通过本纯化方法制备含有小于0.30重量％的2-氨基丙二醇-1,3-的1-氨基丙二醇-2,3，其包括蒸馏含有至少0.3％的2-氨基丙二醇-2,3-二 氨基丙二醇-1,3-基于1-氨基丙二醇-2,3的重量与蒸馏塔，所述蒸馏塔具有低压力损失。