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    METHODS AND SYSTEMS FOR THREE-DIMENSIONAL REAL-TIME INTRAOPERATIVE SURGICAL MARGIN EVALUATION OF TUMOR TISSUES
    31.
    发明申请
    METHODS AND SYSTEMS FOR THREE-DIMENSIONAL REAL-TIME INTRAOPERATIVE SURGICAL MARGIN EVALUATION OF TUMOR TISSUES 有权
    肿瘤组织三维实时手术治疗评估方法与系统

    公开(公告)号：US20140140594A1

    公开(公告)日：2014-05-22

    申请号：US14085732

    申请日：2013-11-20

    Applicant: VANDERBILT UNIVERSITY

    Inventor： Anita Mahadevan-Jansen ,  The Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Holt Ginger ,  Isaac Pence

    IPC: G01N33/483 ,  G06T7/00 ,  G01N21/27

    CPC classification number: G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

    Abstract: In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit a source light; at least one optical probe; a scanner; a spectrometer; and a controller coupled with the scanner and the spectrometer for operably controlling the scanner and the spectrometer. In operation, a working end of the optical probe is positioned proximate to a surface of a specimen of the tumor tissues. A source channel of the optical probe deliver the source light emitted by the light source from the working end to the surface of the specimen, and a plurality of collection channels collect from the working end diffused/reflected light generated from interaction of the source light with the specimen. The spectrometer receives the collected diffused/reflected light to evaluate a margin status of the specimen.

    Abstract translation: 一方面，本发明涉及评价活体受试者的肿瘤组织的手术边缘的系统。 在一个实施例中，该系统包括配置成发射源光的光源; 至少一个光学探针; 扫描仪 光谱仪 以及与扫描器和光谱仪耦合的控制器，用于可操作地控制扫描仪和光谱仪。 在操作中，光学探针的工作端位于肿瘤组织样本的表面附近。 光学探针的源通道将光源发射的源光从工作端传送到样品的表面，并且多个收集通道从工作端收集由源光与光源的相互作用产生的漫射/反射光与 标本。 光谱仪接收收集的扩散/反射光，以评估样品的边缘状态。

    SPR sensor cell and SPR sensor
    32.
    发明授权
    SPR sensor cell and SPR sensor 失效
    SPR传感器单元和SPR传感器

    公开(公告)号：US08718420B2

    公开(公告)日：2014-05-06

    申请号：US13702855

    申请日：2011-06-02

    Applicant: Tomohiro Kontani

    Inventor： Tomohiro Kontani

    IPC: G02B6/00

    CPC classification number: G02B6/036 ,  G01N21/553 ,  G01N2201/08 ,  G01N2201/0846

    Abstract: An SPR sensor cell is an SPR sensor cell including an optical waveguide to be brought into contact with a sample. The optical waveguide includes an under clad layer, a core layer provided in the under clad layer such that at least a part thereof is exposed from the under clad layer, and a metal particle layer covering the core layer exposed from the under clad layer to be brought into contact with the sample.

    Abstract translation: SPR传感器单元是包括要与样品接触的光波导的SPR传感器单元。 光波导包括下包层，芯层层，其设置在下包层中，使得其至少一部分从下包层暴露，并且覆盖从下包层暴露的芯层的金属颗粒层为 与样品接触。

    DEVICE AND METHOD FOR DETECTING PLAQUE IN THE ORAL CAVITY
    35.
    发明申请
    DEVICE AND METHOD FOR DETECTING PLAQUE IN THE ORAL CAVITY 有权
    用于检测口腔中液体的装置和方法

    公开(公告)号：US20110151409A1

    公开(公告)日：2011-06-23

    申请号：US12645542

    申请日：2009-12-23

    Applicant: Curt BINNER

    Inventor： Curt BINNER

    IPC: A61B6/14

    CPC classification number: A61B1/24 ,  A61B1/00165 ,  A61B1/0646 ,  A61B1/0676 ,  A61B5/0088 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0846

    Abstract: The present invention regards methods and devices for detecting plaque on a surface in the oral cavity to which a fluorescent agent capable of binding to plaque has been applied, whereby a radiation source emits incident radiation for contacting the surface, reflected light and fluorescent emission resulting from contact of the radiation with the surface is collected by an optical collector and conveyed by an optical pathway in the device, where the optical light signal of the reflected light and fluorescent emission is converted to an electrical signal, and where the electrical signals of the fluorescent emission and the reflected light are then mathematically manipulated to provide a compensated plaque value as a function of the distance from the optical collector and the surface of the oral cavity to which the fluorescent agent has been applied.

    Abstract translation: 本发明涉及用于在口腔内表面上检测斑块的方法和装置，其中已经施加能够结合斑块的荧光剂，由此辐射源发射用于接触表面的入射辐射，反射光和由 辐射与表面的接触由光学收集器收集并通过设备中的光学路径传送，其中反射光和荧光发射的光学信号被转换为电信号，并且其中荧光 然后数学地操作发射和反射光，以提供作为与光学收集器和已经施加荧光剂的口腔表面的距离的函数的补偿的斑块值。

    Optical Probes for Non-Invasive Analyte Measurements
    39.
    发明申请
    Optical Probes for Non-Invasive Analyte Measurements 审中-公开
    用于非侵入性分析物测量的光学探针

    公开(公告)号：US20080319286A1

    公开(公告)日：2008-12-25

    申请号：US12185217

    申请日：2008-08-04

    Applicant: Trent Ridder ,  Ben ver Steeg ,  Mike Mills

    Inventor： Trent Ridder ,  Ben ver Steeg ,  Mike Mills

    IPC: A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  A61B2562/12 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/4745 ,  G01N2201/0846 ,  Y10T29/49764

    Abstract: An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product.

    Abstract translation: 一种用于非侵入性测量受试者的生物样品中的分析物质的光学探针包括将源光从光学探针输入传送到样品界面的多个照明纤维，多个收集纤维，其将从 样品接口连接到光学探针输出，并且其中照明和收集光纤基本上垂直于样品界面定向，并且照明和收集光纤以多个线性行堆叠以提供以矩形图案布置的纤维堆叠。 光学探针适合于与商业产品一致的尺寸制造。

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