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31.
公开(公告)号:US20190162714A1
公开(公告)日:2019-05-30
申请号:US16312820
申请日:2017-07-07
发明人: Tahereh KARIMI
IPC分类号: G01N33/487 , G06N3/00 , G16B99/00 , G16C99/00 , G01N33/50
摘要: A synthetic, cognitive cell, system, and method for automatically generating an output based on an environmental input is disclosed. The cognitive cell includes an operator including chemical agents, and a coded chemical including polymers. Each of the polymers includes a sequence of affinity blocks of molecular groups arranged in predetermined patterns to define a multi-layered base code. Each of the affinity blocks includes a monomer with a sidechain, the sidechains having affinities to each other. At least a portion of the affinity blocks forming a gate switch defining a bridge between the environmental inputs and the chemical agent whereby, upon exposure to the environmental inputs, the gate switches trigger the chemical agent to perform an operation. The coded chemical and at least one chemical agent are contained within a natural or synthetic membrane.
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公开(公告)号:US20190145894A1
公开(公告)日:2019-05-16
申请号:US16300265
申请日:2017-05-09
发明人: Omer Dushek , Jesse Goyette
摘要: Embodiments of the present invention provide a computer-implemented method of determining characteristics of enzyme catalysis, comprising receiving, from a surface plasmon resonance (SPR) instrument, SPR data indicative of binding of anenzyme and a substrate, and determining one or more characteristics of the enzyme catalysis based on a multi-centre particle density (MPD) model and the SPR data.
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公开(公告)号:US12102428B2
公开(公告)日:2024-10-01
申请号:US17397267
申请日:2021-08-09
发明人: Erwin S. Budiman
摘要: Methods of analyte monitoring management are provided. The methods include indicating on a user interface a plurality of analyte management procedures available for user-selection, where the plurality of analyte management procedures relate to analyte management parameters. Embodiments include receiving an indication to initiate a first procedure of the plurality of analyte management procedures, where the first procedure is for determining a first analyte management parameter. The methods may further include outputting user-instructions associated with the first procedure; receiving analyte measurement data for the first procedure; estimating the first analyte management parameter based on the analyte measurement data; calculating a degree of certainty for the estimation of the first analyte management parameter; and, initiating an action in response to an event associated with a status of the estimation of the first analyte management parameter or the degree of certainty. Analyte monitoring devices and systems implementing the methods are also provided.
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公开(公告)号:US12055554B2
公开(公告)日:2024-08-06
申请号:US18316402
申请日:2023-05-12
发明人: Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号: G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , G16B99/00 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号:US12050228B2
公开(公告)日:2024-07-30
申请号:US17097491
申请日:2020-11-13
申请人: Metabolon, Inc.
发明人: Adam D. Kennedy , Matthew W. Mitchell , Meredith V. Brown , Kay A. Lawton , Shaun Lonergan , Jacob Edward Wulff
IPC分类号: G01N35/00 , G01N33/48 , G01N33/49 , G01N33/50 , G01N33/53 , G01N33/66 , G01N33/68 , G01N33/92 , G16B40/10 , G16B50/00 , G16B50/10 , G16B50/30 , G16B99/00
CPC分类号: G01N35/00613 , G01N33/48 , G01N33/492 , G01N33/50 , G01N33/5308 , G01N33/66 , G01N33/68 , G01N33/92 , G16B40/10 , G16B50/00 , G16B50/10 , G16B50/30 , G16B99/00 , G01N2560/00 , G01N2570/00
摘要: A method of assessing the quality of a biological sample while maintaining the viability of the biological sample for intended use analysis is described herein. The method includes analyzing a biological sample obtained from a subject for an intended use, assessing the quality of the biological sample using one or more biomarkers of sample quality, and simultaneously performing intended use analysis on the same sample. Assessing the quality of the sample can include assessing compliance with sample handling protocols and assessing subject compliance.
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公开(公告)号:US11883195B2
公开(公告)日:2024-01-30
申请号:US16455408
申请日:2019-06-27
申请人: Fitbit, Inc.
IPC分类号: A61B5/0205 , A61B5/00 , G16B99/00 , G01C22/00 , A61B5/11 , G16H20/30 , G16H40/67 , A61B5/024 , G16H20/40
CPC分类号: A61B5/6801 , A61B5/0205 , A61B5/112 , A61B5/1112 , A61B5/1118 , A61B5/1121 , A61B5/1123 , A61B5/4815 , A61B5/4866 , A61B5/681 , A61B5/6824 , A61B5/721 , A61B5/725 , A61B5/726 , A61B5/7207 , A61B5/7235 , A61B5/7257 , A61B5/7264 , A61B5/7282 , G01C22/006 , G16B99/00 , G16H20/30 , G16H40/67 , A61B5/024 , A61B5/7221 , A61B5/7253 , G16H20/40
摘要: The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type. The device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process or the BMD applies a time domain analysis on data provided by a sensor of the BMD for a first activity, and applies a frequency domain analysis on the data for a second activity, which contributes to improved accuracy and speed of biometric data.
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37.
公开(公告)号:US11776664B2
公开(公告)日:2023-10-03
申请号:US16952566
申请日:2020-11-19
申请人: Genomic Health, Inc.
发明人: Wayne Cowens , Steven Shak , Audrey Goddard , Dejan Knezevic , Joffre Baker , Michael C. Kiefer , Tara Maddala , Frederick L. Baehner
IPC分类号: G01N33/574 , G16B99/00 , G16B25/10 , G06N7/01
CPC分类号: G16B99/00 , G01N33/57438 , G06N7/01 , G16B25/10 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要: The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
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公开(公告)号:US11754489B2
公开(公告)日:2023-09-12
申请号:US16091044
申请日:2017-03-29
申请人: LEADWAY (HK) LIMITED
发明人: Haibing Guan , Yu Xu
CPC分类号: G01N15/1459 , G01D5/2448 , G01N15/12 , G01N15/1429 , G01R29/02 , G01N2015/1402 , G01N2015/1486 , G16B99/00
摘要: A pulse baseline value calculation method and a particle counting method of a blood cell analyzer. The said pulse baseline value calculation method, within pulse non-duration time, if an absolute value of a difference value between any two adjacent data of n continuous sampled data is less than a baseline threshold, and the n continuous sampled data are closest to a pulse starting point, an average value of the n continuous sampled data is calculated, and the average value is a pulse baseline value. The present invention has the advantages of setting the baseline threshold and performing comparison, avoiding the sampled data of the baseline where the noise is superimposed, selecting the sampled data with noise or interference within an allowable range for calculation, avoiding accumulating the noise on the final baseline value, making the baseline value be closer to the real data, greatly reducing the erroneous judgment of the baseline value, and making the particle count be more accurate. The method of the present invention can be applied to the particle counting of 3-diff hematology analyzers, 5-diff hematology analyzers, flow cytometers and other biochemical instruments.
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公开(公告)号:US20230273960A1
公开(公告)日:2023-08-31
申请号:US18315237
申请日:2023-05-10
申请人: 23andMe, Inc.
IPC分类号: G06F16/901 , G16H10/60 , G16B10/00 , G16B99/00 , G16Z99/00
CPC分类号: G06F16/9024 , G16B10/00 , G16B99/00 , G16H10/60 , G16Z99/00
摘要: Determining relative connections between individuals includes: obtaining identification information of a first individual and identification information of a second individual; determining, based at least in part on a relative connections graph, a relative connections path connecting the first individual, the second individual, and at least one additional individual; and outputting information pertaining to the relative connections path.
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公开(公告)号:US11710535B2
公开(公告)日:2023-07-25
申请号:US16377680
申请日:2019-04-08
申请人: Sony Corporation
发明人: Kazuhiro Sakurada
IPC分类号: G01N33/48 , G01N33/50 , G16B5/30 , G16B99/00 , A61B5/145 , A61B5/00 , G16B20/00 , G16B5/00 , G16B40/30 , G16B20/20 , G16B40/00 , G16B25/10
CPC分类号: G16B5/30 , A61B5/145 , A61B5/14546 , A61B5/7275 , G16B5/00 , G16B20/00 , G16B20/20 , G16B40/00 , G16B40/30 , G16B99/00 , A61B5/48 , G16B25/10
摘要: Provided is a biological information processing method and a device, a recording medium and a program that are able to predict and control changes in the state of an organism. The expression level of molecules in an organism is measured over a specific time interval; the measured time-series data is divided into a periodic component, an environmental stimulus response component and a baseline component; constant regions of the time-series data are identified from variations in the baseline component or from the amplitude or periodic variations of the periodic component; and causal relation between the identified constant regions is identified. The relation between the external environment and variations in the internal environment is identified and from the identified causal relation between the constant regions, changes in the state of the organism are inferred.
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