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    Benzopyrans
    31.
    发明授权
    Benzopyrans 失效
    苯并吡喃

    公开(公告)号：US4841078A

    公开(公告)日：1989-06-20

    申请号：US639038

    申请日：1984-08-09

    申请人： James F. Eggler ,  Michael R. Johnson ,  Lawrence Sherman

    发明人： James F. Eggler ,  Michael R. Johnson ,  Lawrence Sherman

    IPC分类号： C07C37/055 ,  C07C39/08 ,  C07C43/23 ,  C07C61/39 ,  C07D311/22 ,  C07D311/58 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12 ,  C07D491/10 ,  C07D493/06 ,  C07D493/10

    CPC分类号： C07D405/12 ,  C07C255/00 ,  C07C37/055 ,  C07C41/30 ,  C07C61/39 ,  C07D311/22 ,  C07D311/58 ,  C07D407/12 ,  C07D417/12 ,  C07D491/10 ,  C07D493/06 ,  C07D493/10

    摘要： Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 1 or 2; when B is hydrogen, A is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 0 or 1, when taken together A and OR.sub.1 form a lactone or certain derivatives thereof;(2) A' is ##STR2## (3) A' is Q.sub.3 ; Q is CO.sub.2 R.sub.7, COR.sub.8, C(OH)R.sub.8 R.sub.9, CN, CONR.sub.12 R.sub.13, CH.sub.2 NR.sub.12 R.sub.13, CH.sub.2 NHCOR.sub.14, CH.sub.2 NHSO.sub.2 R.sub.17 or 5-tetrazoyl;Q.sub.3 is ##STR3## 5-tetrazolyl, CH.sub.2 CONHCOR.sub.7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH.sub.2, or COCH.sub.2 Q.sub.4 where Q.sub.4 is CN or COOH or certain esters thereof;R.sub.1 is hydrogen, benzyl or certain acyl groups; R.sub.4 is hydrogen, certain alkyl or certain aralkyl groups; R.sub.5 is hydrogen or certain alkyl groups; Z is (C.sub.1 -C.sub.9)alkylene, optionally interrupted by O, S, SO or SO.sub.2 ; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, anteimetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.

    摘要翻译： 式（I'）的双环稠合苯并噻唑类化合物及其药学上可接受的阳离子和酸加成盐，其中M为O，CH 2或NR 6; R6是氢，甲酰基，苄氧羰基或某些烷氧基烷基，烷酰基，烷基，芳烷基或芳烷基羰基; A'为：（1）其中A和B之一为氢，使得当A为氢时，B为C（R2R3）（CH2）fQ且f为1或2; 当B为氢时，A为C（R2R3）（CH2）fQ，f为0或1，当A和OR1一起形成内酯或其某些衍生物时; （2）A'是（3）A'是Q3; Q是CO 2 R 7，COR 8，C（OH）R 8 R 9，CN，CONR 12 R 13，CH 2 NR 12 R 13，CH 2 NHCOR 14，CH 2 NHSO 2 R 17或5-四唑基; Q 4是CN或COOH或其某些酯; Q 3是CN，COOH或其某些酯;其中Q 4是CN或COOH或其某些酯; R1是氢，苄基或某些酰基; R4是氢，某些烷基或某些芳烷基; R5是氢或某些烷基; Z是（C1-C9）亚烷基，任选地被O，S，SO或SO 2中断; W是氢，甲基，某些芳基或环烷基; 因此在哺乳动物中作为止痛剂，止痛剂，促炎剂，利尿剂，抗惊厥药，止泻药，镇咳药，治疗青光眼有用。

    Process for producing 4',4-dihydroxydiphenyl
    40.
    发明授权
    Process for producing 4',4-dihydroxydiphenyl 失效
    制备4'，4-二羟基二苯基的方法

    公开(公告)号：US4465878A

    公开(公告)日：1984-08-14

    申请号：US400421

    申请日：1982-07-21

    申请人： Takeshi Hashimoto ,  Terumasa Akashi ,  Koji Nishihara

    发明人： Takeshi Hashimoto ,  Terumasa Akashi ,  Koji Nishihara

    IPC分类号： C07C27/00 ,  C07C37/04 ,  C07C37/055 ,  C07C37/82 ,  C07C37/84 ,  C07C39/15 ,  C07C67/00 ,  C07C39/12

    CPC分类号： C07C39/15 ,  C07C37/04 ,  C07C37/055 ,  C07C37/64 ,  C07C37/82 ,  C07C37/84

    摘要： A process for producing 4,4'-dihydroxydiphenyl which comprises subjecting to alkali fusion 1 mol of 4,4'-diphenyldisulfonic acid and/or potassium 4,4'-diphenyldisulfonate together with 4 to 10 mol of potassium hydroxide and 0.1 to 2 mol of potassium sulfate. Alternatively, the process may comprise subjecting to alkali fusion 4,4'-diphenyldisulfonic acid in the presence of potassium hydroxide, controlling to 20 to 25% the potassium hydroxide concentration in the reaction mixture, and separating dipotassium salt of 4,4'-dihydroxydiphenyl.

    摘要翻译： 一种制备4,4'-二羟基二苯基的方法，其包括将1mol 4,4'-二苯基二磺酸和/或4,4'-二苯基二磺酸钾与4至10mol氢氧化钾和0.1至2mol 的硫酸钾。 或者，该方法可以包括在氢氧化钾存在下进行碱熔融4,4'-二苯基二磺酸，控制反应混合物中氢氧化钾浓度的20-25％，并分离出4,4'-二羟基二苯基的二钾盐 。