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公开(公告)号：US20230021091A1
公开(公告)日：2023-01-19
申请号：US17850516
申请日：2022-06-27
申请人： Encodia, Inc.
摘要： Provided herein are modified cleavases for removing amino acids from peptides, polypeptides, and proteins. Also provided are methods of using the modified cleavases for treating polypeptides, and kits comprising the modified cleavase. In some embodiments, the methods and the kits also include other components for macromolecule sequencing and/or analysis.
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公开(公告)号：US20220370993A1
公开(公告)日：2022-11-24
申请号：US17759397
申请日：2021-01-25
发明人： Omar M. Yaghi , Sonja Kuebelbeck , Grit Baier , Joshua C. Speros , Zhe Ji , Bing Zhang , Benjamin Breiten
摘要： Provided are compositions that include a metal-organic framework (MOF) including a framework defining an internal volume, an enzyme disposed within the internal volume, and a surfactant. Also provided are methods of making the compositions and their use.
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公开(公告)号：US11484036B2
公开(公告)日：2022-11-01
申请号：US16301653
申请日：2017-05-16
申请人： NESTEC S.A.
发明人： Yvette Fleury Rey , Christina Vafeiadi , Stephane Duboux , Catherine Ngom-Bru , Cassandra Mokdad , Clementine Tastet , Christof Gysler , Carl Erik Hansen
摘要： The present invention relates to flavour generation. In particular the invention relates to a method for flavour generation in a heat-treated food product using a prolidase enzyme. The invention also relates to a heat-treated food product prepared according to the method of the invention.
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公开(公告)号：US20220332769A1
公开(公告)日：2022-10-20
申请号：US17810131
申请日：2022-06-30
发明人： Chang-Zheng Chen , Guoqiang Dong , Yiling Luo , Hua Zhou , Tian-Qiang Sun , Michael Chen
IPC分类号： C07K14/165 , C12N9/48
摘要： Provided herein are multivalent particles and compositions of multivalent particles for blocking viral infection.
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公开(公告)号：US20220290203A1
公开(公告)日：2022-09-15
申请号：US17749857
申请日：2022-05-20
申请人： KANEKA CORPORATION
发明人： Misato MATSUI , Shingo KOBAYASHI , Naoaki TAOKA
摘要： The present disclosure concerns a method for producing peptides such as glutathione and a microorganism that can be used for such method. One or more embodiments of the first aspect of the present disclosure concern a method for producing peptides such as glutathione comprising culturing a prokaryotic microbial strain in which the expression levels of one or more genes selected from among the gshA gene, the gshB gene, and the gshF gene are enhanced, compared with the expression levels thereof in the wild-type strain thereof in a medium in which the total concentration of cysteine and cystine is 0.5 g/l or lower. The second aspect of the present disclosure concerns a microorganism comprising disruptions of the γ-glutamyltransferase gene and the glutathione reductase gene and exhibiting the enhanced expression levels of the gshA gene and the gshB or gshF gene.
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公开(公告)号：US20220259270A1
公开(公告)日：2022-08-18
申请号：US17626877
申请日：2019-07-16
摘要： The present invention relates to a novel strain of Trichoderma comprising genetic modifications that enable the improved production of an enzyme cocktail, involving at least upregulation of the transcription factor Xyr1 according to SEQ ID No. 1; disruption of the gene ACE1 according to SEQ ID No. 2; disruption of the gene SLP1 according to SEQ ID No. 3; and expression of the gene Cel3a from Rasamsonia emersonii according to SEQ ID No. 4.
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公开(公告)号：US20220227889A1
公开(公告)日：2022-07-21
申请号：US17606759
申请日：2020-04-24
申请人： Encodia, Inc.
发明人： Kevin L. GUNDERSON , Fei HUANG , Robert C. JAMES , Luca MONFREGOLA , Stephen VERESPY, III , Eric Cunyu ZHOU
IPC分类号： C07K17/00 , C07D231/12 , C07K14/195 , C12N9/48
摘要： The present invention relates to methods of cleaving the N-terminal amino acid from a polypeptide, which may be in free form or conjugated to a carrier or surface, such as a bead. It provides methods to activate the N-terminal amine of a polypeptide to promote formation of a cyclic adduct of the N-terminal amino acid, resulting in cleavage of the N-terminal amino acid from the polypeptide. The method can be used to sequence and/or analyze a polypeptide. For example, the methods can be combined with methods described herein for sequencing and/or analysis that employ barcoding and nucleic acid encoding of molecular recognition events, and/or detectable labels. The invention also provides compounds and kits useful for practicing these methods.
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公开(公告)号：US20220175895A1
公开(公告)日：2022-06-09
申请号：US17540289
申请日：2021-12-02
发明人： Ruey-Hwa Chen , Yu-Hsuan Chen , Tzu-Yu Huang , Wen-Hsin Li , Ting-Fen Tsai , Zhao-Qing Shen
摘要： Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.
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公开(公告)号：US20220174981A1
公开(公告)日：2022-06-09
申请号：US17534663
申请日：2021-11-24
发明人： Karsten Matthias KRAGH , Ernst MEINJOHANNS , Andrei MIASNIKOV , Maria MA , Thomas EISELE , Svend HAANING , Peter Edvard DEGN , Steffen Yde BAK
摘要： A method for the production of a hydrolysate comprising: (a) admixing at least one protein or a portion thereof with: (A) at least one endoprotease; and (B) (a′) at least one proline tolerant tripeptidyl peptidase or fermentate comprising a proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having: Proline at P1; and synthetic amino acids at P1; or (b′) at least one proline tolerant tripeptidyl peptidase having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having: Proline at PV; and synthetic amino acids at PV; and (b) recovering the hydrolysate. The invention also relates to methods for producing a hydrolysate comprising the use of an endoprotease an exo-tripeptidyl peptidase of the S53 family and an aminopeptidase, to uses of a proline tolerant tripeptidyl peptidase, compositions, food and/or feed additive compositions comprising the same, as well as hydrolysates and uses of proline tolerant tripeptidyl peptidases.
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公开(公告)号：US11324810B2
公开(公告)日：2022-05-10
申请号：US16221836
申请日：2018-12-17
申请人： Marco Santamaria
发明人： Marco Santamaria
摘要： A method for producing ACE Inhibitor peptides from a protein source or plasma is disclosed. The method utilizes proteolysis by intestinal, blood-circulating, or membrane-bound proteases. The initial synthesis step could require obtaining a protein source either from a human or animal. A protease is added to either a given plasma protein or plasma and incubated. Following incubation, the protease activity must be quenched using a protease inhibitor to inactivate the protease. After incubation with protease inhibitor, the solution will contain a mixture of bioactive ACE inhibitory peptides and inert peptides. This mixture may be purified to select for the ACE inhibitory peptides through centrifugation. The mixture may also be sterilized to remove any microbial contaminants. The ACE inhibitory peptides can be mixed with protein powders, incorporated into baked good and put into other food products to provide food products with the added benefit of lowering blood pressure.
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