公开(公告)号：US08569932B2

公开(公告)日：2013-10-29

申请号：US13252842

申请日：2011-10-04

Applicant: En-Te Hwu ,  Ing-Shouh Hwang

Inventor： En-Te Hwu ,  Ing-Shouh Hwang

IPC: H01L41/08

CPC classification number: G01Q10/04

Abstract: A multi-axis actuating apparatus for a nano-positioning apparatus includes a movable element attached to a sample platform, a plurality of driving elements, and a plurality of actuators. The driving elements frictionally engage the movable element and are configured to selectively move the movable element along a first direction. The plurality of actuators move the plurality of driving elements when driving signals are applied to the plurality of actuators. Different driving signals may be applied to the plurality of actuators to cause different movement of the driving elements such that the movable element has different displacements in different directions along the plurality of driving elements. The movable element is titled due to the different displacements.

Abstract translation: 用于纳米定位装置的多轴致动装置包括附接到样品平台的可移动元件，多个驱动元件和多个致动器。 驱动元件摩擦地接合可移动元件并被构造成沿着第一方向选择性地移动可移动元件。 当驱动信号被施加到多个致动器时，多个致动器移动多个驱动元件。 可以将不同的驱动信号施加到多个致动器以引起驱动元件的不同移动，使得可移动元件在沿着多个驱动元件的不同方向上具有不同的位移。 可移动元件由于不同的位移而被标题。

公开(公告)号：US08492131B2

公开(公告)日：2013-07-23

申请号：US12777569

申请日：2010-05-11

Applicant: Lie-Fen Shyur ,  Chih-An Hsu

Inventor： Lie-Fen Shyur ,  Chih-An Hsu

IPC: C12N9/02 ,  C07K14/00 ,  C12P21/00

CPC classification number: C12N9/0061 ,  C12Y110/03002

Abstract: Novel laccases from Cerrena sp. WR1 and Lentinus sp. and uses thereof.

Abstract translation: Cerrena sp。的新型漆酶 WR1和香菇属 及其用途。

公开(公告)号：US20130185053A1

公开(公告)日：2013-07-18

申请号：US13709495

申请日：2012-12-10

Applicant: Academia Sinica

Inventor： Wen-Lian Hsu

IPC: G06F17/21

CPC classification number: G06F17/21 ,  G06F17/273 ,  G06F17/276

Abstract: For relieving typing burdens caused by incorrect spellings, typing errors, unknown spellings, and characters with diacritical marks, and for enhancing a typing efficiency of a typist with some simplified techniques, several candidate generating methods are provided for assisting the typist to pick a candidate word from a list of generated candidate words, or for selecting a candidate word from said list of generated candidate words in an automatic-selection manner. A proper-designed user interface may also be utilized for implementing the candidate generating methods.

Abstract translation: 为了减轻不正确的拼写造成的打字负担，打字错误，未知的拼写和具有变音标记的字符，并且为了通过一些简化的技术提高打字员的打字效率，提供了几种候选生成方法来帮助打字员挑选候选词 从生成的候选词的列表中，或者以自动选择的方式从生成的候选词的列表中选择候选词。 还可以使用适当设计的用户界面来实现候选生成方法。

公开(公告)号：US08466291B2

公开(公告)日：2013-06-18

申请号：US12609392

申请日：2009-10-30

Applicant: Chun-Hung Lin ,  Ching-Wen Ho

Inventor： Chun-Hung Lin ,  Ching-Wen Ho

IPC: C07D211/00 ,  A61K31/445

CPC classification number: C07D211/40 ,  C07D211/58 ,  C07D401/10 ,  C07D405/10

Abstract: 1,5-Dideoxy-1,5-imino-D-glucitol compounds as shown in the specification. Also disclosed is a method of treating a hexosaminidase-associated disease.

Abstract translation: 1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，如说明书所示。 还公开了一种治疗氨基糖苷酶相关疾病的方法。

公开(公告)号：US20130131151A1

公开(公告)日：2013-05-23

申请号：US13405055

申请日：2012-02-24

Applicant: YEU KUANG HWU ,  S JA TSENG

Inventor： YEU KUANG HWU ,  S JA TSENG

IPC: A61K47/32 ,  C08L33/14 ,  A61K31/711 ,  C08K5/42 ,  A61K31/7105 ,  C08K5/3465 ,  C08K3/02

CPC classification number: A61K31/7105 ,  A61K31/711 ,  C08F222/1006 ,  C08J3/075 ,  C08J9/0014 ,  C08J2201/026 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2371/02

Abstract: A method for preparing a hydrogel includes the steps of injecting a precursor with at least two alkene groups into a predetermined portion, injecting at least one specie into the predetermined portion, and performing an X-ray irradiation on the predetermined portion to induce a polymerization reaction of the precursor to form a porous hydrogel with the specie embedded inside the porous hydrogel. In one embodiment of the present invention, the specie is selected from the group consisting of nucleic acid and adhesion agent.

Abstract translation: 制备水凝胶的方法包括以下步骤：将具有至少两个烯烃基团的前体注入预定部分，将至少一种物质注射到预定部分中，并对该预定部分进行X射线照射以诱导聚合反应 的前体，以形成多孔水凝胶，其中物质嵌入多孔水凝胶内。 在本发明的一个实施方案中，所述物质选自核酸和粘附剂。

公开(公告)号：US20130109077A1

公开(公告)日：2013-05-02

申请号：US13281810

申请日：2011-10-26

Applicant: Yu-Chan Chao ,  Yueh-Lung Wu ,  Carol Pei Yin Wu ,  Chia-Hung Wang

Inventor： Yu-Chan Chao ,  Yueh-Lung Wu ,  Carol Pei Yin Wu ,  Chia-Hung Wang

IPC: C12N7/00 ,  C12N5/10

CPC classification number: C12N7/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/67 ,  C12N15/86 ,  C12N2310/14 ,  C12N2710/14143 ,  C12N2710/14152 ,  C12N2799/027 ,  C12N2800/40 ,  C12N2830/50 ,  C12N2830/75 ,  C12N2830/85 ,  C12N2999/007

Abstract: This invention relates to a method for expressing a gene in a cell. The method includes introducing into a cell an agent that inhibits one or both of miRNA pathway and antiviral defense pathway; and a baculovirus that contains a nucleic acid molecule including a gene operably linked to a promoter; and expressing the gene in the cell.

Abstract translation: 本发明涉及在细胞中表达基因的方法。 该方法包括向细胞中引入抑制miRNA途径和抗病毒防御途径中的一者或两者的药剂; 和包含核酸分子的杆状病毒，所述核酸分子包括可操作地连接于启动子的基因; 并在细胞中表达该基因。

公开(公告)号：US20130102498A1

公开(公告)日：2013-04-25

申请号：US13467036

申请日：2012-05-08

Applicant: Rita P.-Y. Chen ,  Steven Sheng-Shih Wang ,  Chaur-Jong Hu ,  Po-Ting CHEN

Inventor： Rita P.-Y. Chen ,  Steven Sheng-Shih Wang ,  Chaur-Jong Hu ,  Po-Ting CHEN

IPC: C12Q1/37 ,  C07C49/255 ,  C12Q1/02 ,  C07C49/248 ,  C07C49/235 ,  C07C225/22 ,  C07K7/06 ,  C07C59/90

CPC classification number: C12Q1/37 ,  A61K31/235 ,  C07C49/223 ,  C07C49/235 ,  C07C49/248 ,  C07C49/255 ,  C07C59/90 ,  C07C225/22 ,  C07K7/06 ,  C07K14/4711 ,  C12Q1/025 ,  G01N33/5058 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2800/2821

Abstract: Novel substrates for detection of activity of amyloid beta degrading enzyme, such as Neprilysin (NEP) and insulin degrading enzyme (IDE), associated with Alzheimer's disease, are provided. A quenched fluorogenic peptide substrate containing the first seven residues of the Aβpeptide plus a C-terminal Cys residue to detect neprilysin activity with a fluorophore attached to the C-terminal Cys and a quencher linked to the N-terminus of the peptide is disclosed. An assay system sensitive to endopeptidase activity of NEP and IDE, but insensitive to other Aβ-degrading enzymes is disclosed. Active compounds are identified by a cell-based assay system for high-throughput screening.

Abstract translation: 提供了用于检测与阿尔茨海默氏病有关的淀粉样蛋白β降解酶（例如尼泊替宁（NEP）和胰岛素降解酶（IDE））的活性的新型底物。 公开了含有Abetapeptide加上C末端Cys残基的前七个残基的淬灭的荧光肽底物，以检测与附着于C-末端Cys的荧光团和连接于该肽的N末端的猝灭剂的荧光素活性。 公开了对NEP和IDE的内肽酶活性敏感但对其它Aβ降解酶不敏感的测定系统。 通过用于高通量筛选的基于细胞的测定系统鉴定活性化合物。

公开(公告)号：US08426677B2

公开(公告)日：2013-04-23

申请号：US12604808

申请日：2009-10-23

Applicant: Su-May Yu ,  Shuen-Fang Lo ,  Liang-Jwu Chen ,  Tuan-Hua David Ho

Inventor： Su-May Yu ,  Shuen-Fang Lo ,  Liang-Jwu Chen ,  Tuan-Hua David Ho

IPC: A01H5/00 ,  A01H1/00 ,  C07H21/04 ,  C12N5/04 ,  C12N15/05

CPC classification number: C12N15/8297 ,  C12N9/0071 ,  C12N15/8273

Abstract: Novel gibberellin 2-oxidase (GA2ox) genes were identified. Differential expression of GA2ox genes correlated with flower development, seed germination, tiller growth and other developmental processes. In addition, the early and increased growth of tiller and adventitious root and altered root architecture caused by overexpression of GA2oxs further suggest the pleiotropic role of GA2oxs in controlling growth and architecture in plants such as rice. GA2ox5, GA2ox6 and GA2ox9 were three genes encoding class C20 GA2oxs in rice. Mutants or transgenic rice overexpressing class C20 GA2oxs exhibited a broad range of mutant phenotypes, including semi-dwarfism, increased root system and higher tiller numbers that may favor grain yield. Mutations in the conserved domain III were found to affect the physiological activity of class C20 GA2oxs. Methods are described for controlling plant growth and architecture by controlling gene expression of gibberellin 2-oxidase in the plant.

Abstract translation: 鉴定了新型赤霉素2-氧化酶（GA2ox）基因。 GA2ox基因的差异表达与花的发育，种子发芽，分蘖生长等发育过程相关。 此外，由于GA2ox过表达引起的分蘖和不定根的早期增长和根系的改变进一步表明GA2oxs在控制水稻等植物生长和结构方面具有多方位的作用。 GA2ox5，GA2ox6和GA2ox9是水稻中编码C20 GA2oxs的三个基因。 突变体或转基因水稻超过C20类型的GA2oxs表现出广泛的突变表型，包括半侏儒症，增加的根系和较高的分蘖数，可能有利于谷物产量。 发现保守结构域III中的突变会影响C20类GA2氧化酶的生理活性。 描述了通过控制植物中赤霉素2-氧化酶的基因表达来控制植物生长和结构的方法。

公开(公告)号：US08383767B2

公开(公告)日：2013-02-26

申请号：US12491521

申请日：2009-06-25

Applicant: Jaulang Hwang ,  Chun-Cheng Lin ,  Hsiao-Ling Chiang ,  Fan-Dan Jan ,  Chiao-En Chen ,  Chia-Tse Shu

Inventor： Jaulang Hwang ,  Chun-Cheng Lin ,  Hsiao-Ling Chiang ,  Fan-Dan Jan ,  Chiao-En Chen ,  Chia-Tse Shu

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/38 ,  A61K45/00 ,  A61K47/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00

CPC classification number: C07K14/21 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/28 ,  C07K14/33 ,  C07K16/3076 ,  C07K16/3084 ,  C07K2319/30 ,  C07K2319/55 ,  Y02A50/472

Abstract: A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen conjugated to multiple cysteine residues in the cysteine-rich domain, and an immune composition containing the immunoconjugate and an adjuvant, as well as their uses in eliciting immune responses.

Abstract translation: 含有抗原呈递细胞结合结构域和富含半胱氨酸的结构域的蛋白质载体。 本文还描述了含有具有与富含半胱氨酸的结构域中的多个半胱氨酸残基缀合的抗原的蛋白质载体的免疫缀合物，以及含有免疫缀合物和佐剂的免疫组合物，以及它们在引发免疫应答中的用途。

公开(公告)号：US08309913B2

公开(公告)日：2012-11-13

申请号：US12689506

申请日：2010-01-19

Applicant: Yi-Sheng Wang ,  Chung-Hsuan Chen

Inventor： Yi-Sheng Wang ,  Chung-Hsuan Chen

IPC: H01J49/10

CPC classification number: H01J49/40 ,  H01J49/0095

Abstract: An angled dual-polarity mass spectrometer includes a dual-polarity ion generator, a first mass analyzer, and a second mass analyzer. The dual-polarity ion generator includes an ion source to generate positive ions and negative ions from a sample, and electrodes to generate electric fields for guiding the negative ions into a beam of negative ions and guiding the positive ions into a beam of positive ions. The first mass analyzer can analyze the negative ions, and the second mass analyzer can analyze the positive ions. The central axes of the first and the second mass analyzers are at an angle between 0 to 179 degrees.

Abstract translation: 角度双极性质谱仪包括双极性离子发生器，第一质量分析器和第二质量分析器。 双极性离子发生器包括从样品产生正离子和负离子的离子源，以及用于产生电场的电极，用于将负离子引导到负离子束中并将正离子引导到正离子束中。 第一个质谱仪可以分析负离子，第二个质谱仪可以分析正离子。 第一和第二质量分析器的中心轴线在0至179度之间的角度。