公开(公告)号：US08586348B2

公开(公告)日：2013-11-19

申请号：US13240347

申请日：2011-09-22

Applicant: Jun Wang ,  James R. Heath

Inventor： Jun Wang ,  James R. Heath

IPC: C12M1/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/00 ,  G01N15/06 ,  G01N30/96

CPC classification number: G01N33/54386 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/086

Abstract: Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further adapted to detect a target material comprised within one of the fluid components. The method comprises providing a channel, the channel having a dimension which is a function of a dimension of one of the fluid components and deliver the fluid through the channel at a set flow rate.

Abstract translation: 本文提供了用于控制流体的不同流体组分的流动的微流体装置和相关方法。 微流体装置包括输入通道，聚焦通道和测定通道。 微流体装置适于将流体分离成至少两个流体组分，并且还适于检测包含在流体组分之一内的目标材料。 该方法包括提供通道，通道具有作为流体部件中的一个的尺寸的函数的尺寸，并以设定的流速输送通过通道的流体。

公开(公告)号：US20120097204A1

公开(公告)日：2012-04-26

申请号：US13278074

申请日：2011-10-20

Applicant: Jen-Kan Yu ,  Slobodan Mitrovic ,  James R. Heath

Inventor： Jen-Kan Yu ,  Slobodan Mitrovic ,  James R. Heath

IPC: H01L35/02 ,  H01L21/265 ,  B32B3/24 ,  H01L21/22

CPC classification number: H01L35/26 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24273 ,  Y10T428/24298

Abstract: A nanomesh phononic structure includes: a sheet including a first material, the sheet having a plurality of phononic-sized features spaced apart at a phononic pitch, the phononic pitch being smaller than or equal to twice a maximum phonon mean free path of the first material and the phononic size being smaller than or equal to the maximum phonon mean free path of the first material.

Abstract translation: 纳米级声子结构包括：包括第一材料的片材，该片材具有以声子间距间隔开的多个声子大小的特征，声子间距小于或等于第一材料的最大声子平均自由程的两倍 并且声子尺寸小于或等于第一材料的最大声子平均自由程。

公开(公告)号：US07948271B1

公开(公告)日：2011-05-24

申请号：US09282045

申请日：1999-03-29

Applicant: Philip J. Kuekes ,  James R. Heath

Inventor： Philip J. Kuekes ,  James R. Heath

IPC: H03K19/20 ,  H03K19/082

CPC classification number: H03K19/20 ,  B82Y10/00 ,  H01L27/101 ,  H01L27/1021 ,  H01L27/285 ,  H01L29/0665 ,  H01L29/0673

Abstract: A programmable logic array (PLA) comprising a two-dimensional array of a plurality of nanometer-scale switches is provided. Each switch comprises a pair of crossed wires which form a junction where one wire crosses another and at least one connector species connecting the pair of crossed wires in the junction. The connector species comprises a bi-stable molecule. A plurality of switches is configurable as an AND gate and a plurality of switches is configurable as an OR gate.

Abstract translation: 提供了包括多个纳米级开关的二维阵列的可编程逻辑阵列（PLA）。 每个开关包括一对交叉的线，其形成一条线与另一条线交叉的连接处，以及至少一个在连接处连接一对交叉线的连接器种类。 连接器种类包括双稳态分子。 多个开关可配置为与门，并且多个开关可配置为或门。

公开(公告)号：US20110039717A1

公开(公告)日：2011-02-17

申请号：US12652000

申请日：2010-01-04

Applicant: Gabriel A. Kwong ,  Ryan C. Bailey ,  Rong Fan ,  James R. Heath

Inventor： Gabriel A. Kwong ,  Ryan C. Bailey ,  Rong Fan ,  James R. Heath

IPC: C40B30/04

CPC classification number: G01N33/6845 ,  C12Q1/6834 ,  C12Q2563/131

Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.

Abstract translation: 本文提供了用于基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。 所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。

公开(公告)号：US20080131327A1

公开(公告)日：2008-06-05

申请号：US11862127

申请日：2007-09-26

Applicant: Robert Michael VAN DAM ,  Arkadij ELIZAROV ,  James R. HEATH

Inventor： Robert Michael VAN DAM ,  Arkadij ELIZAROV ,  James R. HEATH

IPC: B01L11/00 ,  B29C65/00 ,  B32B38/00

CPC classification number: G01N35/1095 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  G01N2035/00158

Abstract: An interface system and device for interfacing a microfluidic chip system is disclosed comprising an adapter having channels and ports connecting to the microfluidic chip system and an external fluidic system. An interface, device and method are provided herein, that disclose the connection of larger volumes of an external fluidic system to smaller volumes of a microfluidic chip system and the ability to effectively purge microfluidic channels without contamination.

Abstract translation: 公开了一种用于接口微流控芯片系统的接口系统和设备，其包括具有连接到微流体芯片系统和外部流体系统的通道和端口的适配器。 本文提供了一种界面，装置和方法，其公开了较大体积的外部流体系统与较小体积的微流体芯片系统的连接以及有效地清除微流体通道而没有污染的能力。

公开(公告)号：US06903366B2

公开(公告)日：2005-06-07

申请号：US10699172

申请日：2003-10-31

Applicant: James R. Heath ,  R. Stanley Williams ,  Philip J. Kuekes

Inventor： James R. Heath ,  R. Stanley Williams ,  Philip J. Kuekes

IPC: B81B7/04 ,  B82B1/00 ,  G01R31/28 ,  G11C13/02 ,  H01L21/00 ,  H01L23/532 ,  H01L27/10 ,  H01L29/861 ,  H01L51/00 ,  H01L51/05 ,  H01L51/30 ,  H01L51/40 ,  H01L29/06

CPC classification number: H01L27/10 ,  B82B1/00 ,  B82Y10/00 ,  B82Y30/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/02 ,  G11C2213/72 ,  G11C2213/77 ,  G11C2213/81 ,  H01L51/0595 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/936

Abstract: A route to the fabrication of electronic devices is provided, in which the devices consist of two crossed wires sandwiching an electrically addressable molecular species. The approach is extremely simple and inexpensive to implement, and scales from wire dimensions of several micrometers down to nanometer-scale dimensions. The device of the present invention can be used to produce crossbar switch arrays, logic devices, memory devices, and communication and signal routing devices. The present invention enables construction of molecular electronic devices on a length scale than can range from micrometers to nanometers via a straightforward and inexpensive chemical assembly procedure. The device is either partially or completely chemically assembled, and the key to the scaling is that the location of the devices on the substrate are defined once the devices have been assembled, not prior to assembly.

Abstract translation: 提供了制造电子器件的途径，其中器件由夹着电可寻址分子种类的两条交叉导线组成。 该方法实现起来非常简单和便宜，并且从几微米的线尺寸缩小到纳米级尺寸。 本发明的装置可用于产生交叉开关阵列，逻辑器件，存储器件以及通信和信号路由器件。 本发明能够通过直接且廉价的化学组装程序在长度尺度上构建分子电子器件，其尺寸范围可以从微米到纳米。 该装置部分或完全化学地组装，并且缩放的关键在于，一旦装置组装而不是装配之前，基板上的装置的位置被定义。

公开(公告)号：US06756296B2

公开(公告)日：2004-06-29

申请号：US10015063

申请日：2001-12-11

Applicant: James R. Heath ,  Charles P. Collier ,  Yi Luo ,  Erica DeIonno ,  Patricia A. Beck

Inventor： James R. Heath ,  Charles P. Collier ,  Yi Luo ,  Erica DeIonno ,  Patricia A. Beck

IPC: H01L214763

CPC classification number: H01L27/285 ,  B82Y10/00 ,  H01L51/0052 ,  H01L51/0067 ,  H01L51/0591 ,  H01L51/0595 ,  Y10T428/12542 ,  Y10T428/24917 ,  Y10T428/31663

Abstract: Methods for making electronic devices where a molecular monolayer or multilayer is sandwiched between top and bottom electrodes at electrode intersections. The molecular layer has an electrical characteristic such as bistable switching. A layer of electrically conductive material is used to protect the molecular layer during formation of the top electrode pattern. The electrically conductive material remains sandwiched between the top and bottom electrodes at the electrode intersections in the final electronic device.

Abstract translation: 制造电子器件的方法，其中分子单层或多层被夹在电极交叉处的顶部和底部电极之间。 分子层具有诸如双稳态切换的电特性。 在形成顶部电极图案期间，使用一层导电材料来保护分子层。 导电材料保持夹在最终电子设备中的电极交叉处的顶部和底部电极之间。

公开(公告)号：US06459095B1

公开(公告)日：2002-10-01

申请号：US09282048

申请日：1999-03-29

Applicant: James R. Heath ,  R. Stanley Williams ,  Philip J. Kuekes

Inventor： James R. Heath ,  R. Stanley Williams ,  Philip J. Kuekes

IPC: H01L2906

CPC classification number: H01L27/10 ,  B82B1/00 ,  B82Y10/00 ,  B82Y30/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/02 ,  G11C2213/72 ,  G11C2213/77 ,  G11C2213/81 ,  H01L51/0595 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/936

Abstract: A route to the fabrication of electronic devices is provided, in which the devices consist of two crossed wires sandwiching an electrically addressable molecular species. The approach is extremely simple and inexpensive to implement, and scales from wire dimensions of several micrometers down to nanometer-scale dimensions. The device of the present invention can be used to produce crossbar switch arrays, logic devices, memory devices, and communication and signal routing devices. The present invention enables construction of molecular electronic devices on a length scale than can range from micrometers to nanometers via a straightforward and inexpensive chemical assembly procedure. The device is either partially or completely chemically assembled, and the key to the scaling is that the location of the devices on the substrate are defined once the devices have been assembled, not prior to assembly.

Abstract translation: 提供了制造电子器件的途径，其中器件由夹着电可寻址分子种类的两条交叉导线组成。 该方法实现起来非常简单和便宜，并且从几微米的线尺寸缩小到纳米级尺寸。 本发明的装置可用于产生交叉开关阵列，逻辑器件，存储器件以及通信和信号路由器件。 本发明能够通过直接且廉价的化学组装程序在比例范围从微米到纳米的范围内构建分子电子器件。 该装置部分或完全化学地组装，并且缩放的关键在于，一旦装置组装而不是装配之前，基板上的装置的位置被定义。

公开(公告)号：US06314019B1

公开(公告)日：2001-11-06

申请号：US09280225

申请日：1999-03-29

Applicant: Philip J. Kuekes ,  R. Stanley Williams ,  James R. Heath

Inventor： Philip J. Kuekes ,  R. Stanley Williams ,  James R. Heath

IPC: G11C1100

CPC classification number: G11C13/025 ,  B82Y10/00 ,  G11C13/0009 ,  G11C2213/34 ,  G11C2213/77 ,  G11C2213/81 ,  Y10S977/708 ,  Y10S977/762 ,  Y10S977/765 ,  Y10S977/936

Abstract: A molecular-wire crossbar interconnect for signal routing and communications between a first level and a second level in a molecular-wire crossbar is provided. The molecular wire crossbar comprises a two-dimensional array of a plurality of nanometer-scale switches. Each switch is reconfigurable and self-assembling and comprises a pair of crossed wires which form a junction where one wire crosses another and at least one connector species connecting the pair of crossed wires in the junction. The connector species comprises a bi-stable molecule. Each level comprises at least one group of switches and each group of switches comprises at least one switch, with each group in the first level connected to all other groups in the second level in an all-to-all configuration to provide a scalable, defect-tolerant, fat-tree networking scheme. The primary advantage is ease of fabrication, because an active switch is formed any time two wires cross. This saves tremendously on circuit area (a factor of a few times ten), since no other wires or ancillary devices are needed to operate the switch or store the required configuration. This reduction of the area of a configuration bit and its switch to just the area of two crossing wires is a major advantage in constructing a defect-tolerant interconnect network.

Abstract translation: 提供了用于分子线交叉开关中的信号路由和第一级和第二级之间的通信的分子线交叉开关互连。 分子线交叉杆包括多个纳米级开关的二维阵列。 每个开关是可重构和自组装的，并且包括一对交叉线，其形成一条线与另一条线交叉的连接处，以及至少一个在连接处连接一对交叉线的连接器种类。 连接器种类包括双稳态分子。 每个级别包括至少一组交换机，并且每组交换机包括至少一个交换机，其中第一级别中的每个组以全对齐配置连接到第二级别中的所有其他组，以提供可扩展的缺陷 不容忍，胖树联网方案。 主要优点是易于制造，因为在任何时候两根线交叉时形成有源开关。 由于不需要其他电线或辅助设备来操作交换机或存储所需的配置，因此可大大节省电路面积（十倍）。 配置位区域的这种减少及其切换到两条交叉电线的区域是构建容错互连网络的主要优点。

公开(公告)号：US6103868A

公开(公告)日：2000-08-15

申请号：US91389

申请日：1998-06-18

Applicant: James R. Heath ,  Daniel V. Leff

Inventor： James R. Heath ,  Daniel V. Leff

IPC: C30B7/00 ,  C08F6/12 ,  B32B1/00 ,  C08J3/14

CPC classification number: C30B29/02 ,  C30B29/605 ,  C30B7/00 ,  C30B7/005 ,  Y10T428/2982

Abstract: Organically functionalized metal nanoparticles are produced by mixing a metal precursor with an organic surface passivant and reacting the resulting mixture with a reducing agent to generate free metal while binding the passivant to the surface of the free metal to produce organically functionalized metal particles.

Abstract translation: PCT No.PCT / US96 / 20402 Sec。 371日期1998年6月18日 102（e）1998年6月18日PCT 1996年12月27日PCT PCT。 出版物WO97 / 24224 PCT 日期1997年7月10日通过将金属前体与有机表面钝化剂混合并将所得混合物与还原剂反应产生游离金属，同时将钝化剂结合到游离金属的表面以产生有机官能化金属 粒子。