公开(公告)号：US4616801A

公开(公告)日：1986-10-14

申请号：US572712

申请日：1984-01-20

申请人： Goeran Cewers ,  Jan Johansson ,  Sven-Gunnar Olsson

发明人： Goeran Cewers ,  Jan Johansson ,  Sven-Gunnar Olsson

IPC分类号： A61M5/00 ,  A61M5/168 ,  A61M5/175 ,  F16L55/14 ,  F16K51/00

CPC分类号： A61M5/16813

摘要： In order to be able to regulate in a simple and reliable manner the quantity of liquid that is administered to a patient through a hose in an infusion device, there is provided, according to the invention, a motor-driven eccentric, which presses the hose against a blocking device and clamps it off to a greater or lesser degree. The blocking device forms a part of at least one guide for the hose and can assume two positions. In one of the positions the guide is released; in the other position it is closed. A lever mounted with freedom to rotate, which can be spring-loaded, is particularly well suited for the blocking device. In addition, a clamping lever which can be activated through an electromagnetic latch, can be provided as an emergency stop.

摘要翻译： 为了能够以简单和可靠的方式调节通过输液装置中的软管施用于患者的液体量，根据本发明，提供了一种电动偏心器，其将软管按压 抵抗阻塞装置并将其夹紧到或多或少的程度。 阻塞装置形成软管的至少一个引导件的一部分，并且可以采取两个位置。 在其中一个位置，指南被释放; 在另一个位置，它是关闭的。 安装有自由旋转的杠杆，其可以是弹簧加载的，特别适用于阻挡装置。 此外，可以提供可以通过电磁闩锁启动的夹紧杆作为紧急停止。

公开(公告)号：US09157070B2

公开(公告)日：2015-10-13

申请号：US13639763

申请日：2011-04-12

申请人： Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Ulrika Johansson ,  Mona Widhe

发明人： Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Ulrika Johansson ,  Mona Widhe

IPC分类号： C12N5/00 ,  C12N5/071 ,  A61L27/22 ,  A61L27/38 ,  A61L27/56 ,  C07K14/005 ,  C07K14/435 ,  D01F4/02 ,  C12N5/0735 ,  C12N5/0797 ,  C12N5/0789 ,  C12N5/077

CPC分类号： C12N5/0068 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/56 ,  C07K14/005 ,  C07K14/43518 ,  C12N5/0606 ,  C12N5/0623 ,  C12N5/0629 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/067 ,  C12N5/0676 ,  C12N5/0691 ,  C12N2500/82 ,  C12N2533/50 ,  C12N2539/00 ,  D01F4/02

摘要： A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein.

摘要翻译： 提供了用于培养真核细胞的方法和组合，以及用于制备真核细胞的方法。 所述方法包括提供待培养的真核细胞样品，将所述样品施用于细胞支架材料; 以及在适于细胞培养的条件下保持所述细胞支架材料具有施加于其上的细胞。 该组合包含真核细胞和细胞支架材料。 细胞支架材料包括蜘蛛丝蛋白的聚合物。

公开(公告)号：US09149343B2

公开(公告)日：2015-10-06

申请号：US13143654

申请日：2010-01-20

申请人： Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

发明人： Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

IPC分类号： A61C7/00 ,  A61C5/12

CPC分类号： A61C5/127 ,  A61C5/85 ,  A61C5/88

摘要： A dental instrument, suitable for use when creating a dental filling, is provided. The dental instrument includes a wedge and a matrix. The matrix is fixedly attached to the wedge, and the wedge is adapted to be inserted into the approximal space between two teeth of a patient. The wedge has a bow shape along a length axis of the wedge, the matrix has a first bow shape along a length axis of the matrix, and the matrix also has a second bow shape along an axis perpendicular to the length axis of the matrix. A method of using the dental instrument and a disposable system, which further comprises a protective member, is further provided.

摘要翻译： 提供了适用于创建牙科填充物时使用的牙科器械。 牙科仪器包括楔形物和矩阵。 矩阵固定地附接到楔形件，楔形件适于插入患者的两个牙齿之间的近似空间中。 楔形物沿着楔形物的长度轴线具有弓形形状，矩阵沿着矩阵的长度轴线具有第一弓形形状，矩阵还沿着垂直于矩阵的长度轴线的轴线具有第二弓形形状。 还提供了一种使用牙科器械的方法和还包括保护构件的一次性系统。

公开(公告)号：US08785391B2

公开(公告)日：2014-07-22

申请号：US13805574

申请日：2010-06-24

申请人： Jan Johansson

发明人： Jan Johansson

IPC分类号： C07K14/47 ,  C07K16/18 ,  A61K38/48 ,  A61K49/00 ,  G01N33/53 ,  A61K9/00 ,  A61K38/00

CPC分类号： C07K14/47 ,  A61K9/0019 ,  A61K38/00 ,  C07K14/4711

摘要： An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human, chimpanzee, bovine, pig, mouse and rat.

摘要翻译： 提供分离的蛋白质用于治疗哺乳动物（包括人）中从阿尔茨海默病，家族性丹麦痴呆和家族性英国痴呆中选择的病症。 分离的蛋白质选自包含与来自人的Bri2的残基90-236具有至少70％同一性的氨基酸序列的蛋白质; 和包含与来自人，黑猩猩，牛，猪，小鼠和大鼠的Bri2的任何一个Brichos结构域具有至少70％同一性的氨基酸序列的蛋白质。

公开(公告)号：US08642734B2

公开(公告)日：2014-02-04

申请号：US13264938

申请日：2010-04-21

申请人： Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

发明人： Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

IPC分类号： A61K38/17

CPC分类号： C07K14/43518

摘要： A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerization of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerization of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider silk protein polymers are isolated from the liquid medium. The resulting polymers are useful as fibers, films, foams, nets or meshes.

摘要翻译： 制备分离的蜘蛛丝蛋白质的聚合物的方法包括提供所述蜘蛛丝蛋白质在pH6.4或更高的液体培养基中的溶液和/或防止蜘蛛丝蛋白聚合的离子组合物。 将液体介质的性质调节至6.3或更低的pH，以及允许蜘蛛丝蛋白质聚合的离子组合物。 允许蜘蛛丝蛋白在液体培养基中形成聚合物，并且从液体培养基中分离得到的蜘蛛丝蛋白聚合物。 所得聚合物可用作纤维，薄膜，泡沫，网或网。

公开(公告)号：US20130336721A1

公开(公告)日：2013-12-19

申请号：US13827465

申请日：2013-03-14

申请人： Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody ,  Arne LaVen ,  Jon Bessette

发明人： Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody ,  Arne LaVen ,  Jon Bessette

IPC分类号： E21D11/00 ,  E21D13/00

CPC分类号： F17C1/007 ,  E21B36/00 ,  E21D11/00 ,  E21D11/38 ,  E21D13/00 ,  F17C1/14 ,  F17C2201/0109 ,  F17C2201/0138 ,  F17C2201/019 ,  F17C2201/035 ,  F17C2201/037 ,  F17C2201/052 ,  F17C2203/0304 ,  F17C2203/0604 ,  F17C2203/0617 ,  F17C2203/0619 ,  F17C2203/0639 ,  F17C2203/0678 ,  F17C2205/0142 ,  F17C2221/031 ,  F17C2221/033 ,  F17C2223/0123 ,  F17C2223/035 ,  F17C2223/036 ,  F17C2227/0192 ,  F17C2260/046 ,  F17C2270/0581

摘要： In various embodiments, lined underground reservoirs and/or insulated pipeline vessels are utilized for storage of compressed fluid in conjunction with energy storage and recovery systems.

摘要翻译： 在各种实施例中，使用衬里的地下储存器和/或绝缘管道容器用于与能量储存和回收系统一起存储压缩流体。

公开(公告)号：US20120329992A1

公开(公告)日：2012-12-27

申请号：US13598119

申请日：2012-08-29

申请人： Jan JOHANSSON ,  Göran HJÄLM ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

发明人： Jan JOHANSSON ,  Göran HJÄLM ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

IPC分类号： C07K14/435 ,  C12P21/02 ,  C12N15/62 ,  C07K19/00 ,  C12N15/12

CPC分类号： C07K14/43518 ,  A61K35/12 ,  A61K47/42 ,  D01F4/00

摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.

公开(公告)号：US07811988B2

公开(公告)日：2010-10-12

申请号：US10558563

申请日：2004-05-26

申请人： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson

发明人： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson

IPC分类号： A61K31/23

CPC分类号： A61K9/0073

摘要： The present invention provides novel lipid mixtures for synthetic surfactants. In particular, the invention provides a specific lipid mixture containing a specific amount of polyunsaturated phospholipids to be used for the preparation of synthetic surfactants. Said surfactants and pharmaceutical compositions thereof are useful for the treatment of surfactant deficiencies like respiratory distress syndrome (RDS).

摘要翻译： 本发明提供了用于合成表面活性剂的新型脂质混合物。 特别地，本发明提供了一种含有特定量的用于制备合成表面活性剂的多不饱和磷脂的脂质混合物。 所述表面活性剂及其药物组合物可用于治疗表面活性剂缺乏症如呼吸窘迫综合征（RDS）。

公开(公告)号：US07716639B2

公开(公告)日：2010-05-11

申请号：US11304973

申请日：2005-12-15

申请人： Kenneth Dahlin ,  Jan Johansson

发明人： Kenneth Dahlin ,  Jan Johansson

IPC分类号： G06F9/45

CPC分类号： G06Q10/10

摘要： A system for facilitating the creation of design specifications includes a computer and a database having stored thereon data indicative of a plurality of storage locations in a processed specification into which data may be entered. Software executing on the computer: displays a requirements document; receives an indication of a selected portion of the requirements document; based at least in part upon the indication of the selected portion of the requirements document, retrieves from the database a list of possible storage locations corresponding to the selected portion of the requirements document; displays the list of possible storage locations corresponding to the selected portion of the requirements document; receives an indication of a selected storage location; receives an indication of data selected in the requirements document to be stored in the selected storage location; and stores the selected data in the selected storage location in the processed specification.

摘要翻译： 用于促进创建设计规范的系统包括计算机和数据库，其上存储有指示可以输入数据的处理的规范中的多个存储位置的数据。 在计算机上执行的软件：显示要求文件; 接收要求文件的所选部分的指示; 至少部分地基于所述要求文档的所选部分的指示，从数据库检索与所述要求文档的所选部分相对应的可能的存储位置的列表; 显示与要求文件的所选部分相对应的可能存储位置的列表; 接收所选存储位置的指示; 接收要求文件中选择的要存储在所选存储位置的数据的指示; 并将所选择的数据存储在所选择的存储位置中。

公开(公告)号：US20100003090A1

公开(公告)日：2010-01-07

申请号：US12488732

申请日：2009-06-22

申请人： Jan JOHANSSON ,  Anders LILJEREHN

发明人： Jan JOHANSSON ,  Anders LILJEREHN

IPC分类号： B23P15/28

CPC分类号： B23C5/202 ,  B23C2200/125 ,  B23C2200/165 ,  B23C2200/286 ,  B23C2210/0407 ,  Y10T407/1924 ,  Y10T407/1936 ,  Y10T407/23

摘要： An indexable milling insert, including an upperside, an underside parallel to an imaginary reference plane, and two cutting edges. Each cutting edge includes a cutting edge line and is formed between a chip surface included in the upperside and a first clearance surface extending between the upperside and the underside, the first clearance surface forming an acute, nominal first clearance angle (α) with a normal to the reference plane. Each cutting edge includes a main edge, which is at least partly convexly curved as viewed in plane elevation from above, and which extends from an initial end, which determines the maximal cutting depth of the milling insert, to a corner edge having a radius of curvature that is smaller than the radius of curvature of the main edge, the main edge rising in the direction from the initial end toward the corner edge such that the distance thereof to the underside successively increases in the direction. A second clearance surface is formed between the cutting edge line and the first clearance surface, the second clearance surface having a width of at most 0.3 mm and a nominal second clearance angle (λ) that is smaller than the first clearance angle. The second clearance surface is of uniform width and the second clearance angle decreases successively in the direction from the initial end toward the corner edge.

摘要翻译： 一个可转位铣削刀片，包括上侧，平行于虚拟参考平面的下侧和两个切削刃。 每个切割边缘包括切割边缘线，并且形成在包括在上侧的切屑表面和在上侧和下侧之间延伸的第一间隙表面之间，第一间隙表面形成具有正常的锐角的标称第一间隙角（α） 到参考平面。 每个切削刃包括主边缘，该主边缘从俯视图中至少部分地凸起弯曲，并且从初始端延伸，该初始端将铣削刀片的最大切削深度确定为具有半径为 曲率小于主边缘的曲率半径，主边沿从初始端朝向角边缘的方向上升，使得其向下侧的距离在该方向上连续增加。 第二间隙表面形成在切削刃线和第一间隙表面之间，第二间隙表面具有至多0.3mm的宽度和小于第一间隙角的标称第二间隙角（lambda）。 第二间隙表面具有均匀的宽度，并且第二间隙角度在从初始端朝向拐角边缘的方向上连续减小。