公开(公告)号：US5968794A

公开(公告)日：1999-10-19

申请号：US12645

申请日：1998-01-23

Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07H1/02 ,  C07K1/04

CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently bonded to the nucleus and a layer of phospholipids hydrophobically bonded to the layer of fatty acid compounds. Dextran, cellulose or starch may be cross-linked with epichlorohydrin to form a cross-linked polysaccharide matrix. Ionic ligands may be grafted using an acidic compound such as succinic acid, phosphoric acid or phosphorous oxychloride, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino) ethylamine fastened onto the grafted acidic compound. Phosphoric acid or phosphorous oxychloride in one step provide both cross-linking and ionic ligands. Co-cross-linking can be obtained using a protein such as keratin, collagen or elastase. The vector may be prepared by reacting succinic acid monochloride with a cross-linked polysaccharide matrix to graft succinic acid onto the matrix to form the nucleus having ionic ligands, grinding the nucleus to a size between 10 .mu.nm and 10 .mu.m, drying, coupling fatty acid compounds to the nucleus and hydrophobically bonding phospholipids to the fatty acid compounds. After coupling the fatty acid compounds and before bonding the phospholipids, a molecule having biological activity may be added. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其含有由具有接枝离子配体的交联多糖或寡糖基质形成的核，与核共价键合的脂肪酸化合物层和与层疏水结合的磷脂层 的脂肪酸化合物。 葡聚糖，纤维素或淀粉可以与表氯醇交联以形成交联的多糖基质。 离子配体可以使用酸性化合物如琥珀酸，磷酸或三氯氧磷，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基）乙胺接枝在接枝的酸性化合物上。 磷酸或磷酰氯在一个步骤中提供交联和离子配体。 可以使用蛋白质如角蛋白，胶原或弹性蛋白酶获得共交联。 载体可以通过使琥珀酸一氯化物与交联的多糖基质反应来制备，以将琥珀酸接枝到基质上以形成具有离子配体的核，将细胞核研磨至10μm至10μm之间的大小，干燥，偶联 脂肪酸化合物到细胞核并将磷脂疏水性结合到脂肪酸化合物上。 偶联脂肪酸化合物之后，在磷脂结合之前，可以加入具有生物活性的分子。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

公开(公告)号：US10776725B2

公开(公告)日：2020-09-15

申请号：US12815375

申请日：2010-06-14

Applicant: Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

Inventor： Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

IPC: G06F9/44 ,  G06Q10/04 ,  G06Q10/10

Abstract: A method for implementing a graphical modeling tool in a web-based environment is disclosed herein. In one embodiment, such a method may include enabling a user to import, into a web-based environment, a domain meta model comprising a number of meta model elements. The method may further enable the user to associate the meta model elements with graphical representations in the web-based environment, thereby allowing the user to create palette elements. The user may then assemble the palette elements on a canvas to create a diagram. This diagram may be converted into an instance of the domain meta model. This instance may be validated for conformance with the rules and constraints associated with the domain meta model. A corresponding apparatus and computer program product are also disclosed and claimed herein.

公开(公告)号：US20150378879A1

公开(公告)日：2015-12-31

申请号：US14319786

申请日：2014-06-30

Applicant: Li Ding

Inventor： Li Ding

IPC: G06F11/36

CPC classification number: G06F11/3688 ,  G06F11/3684

Abstract: An embodiment of a method of testing software can include, as performed by at least one computing device, evaluating a first criterion for a plurality of software components, selecting a subset of the plurality of software components based on the evaluated first criterion, evaluating a second criterion for a plurality of test cases each defining a respective test to evaluate functionality of at least one of the software components, selecting a subset of the plurality of test cases based on the evaluated second criterion, and testing the selected subset of the plurality of software components utilizing the selected subset of the plurality of test cases.

Abstract translation: 测试软件的方法的实施例可以包括如由至少一个计算设备执行的评估多个软件组件的第一标准，基于所评估的第一标准来选择所述多个软件组件的子集，评估第二标准 多个测试用例的标准，每个测试用例定义相应的测试以评估软件组件中的至少一个的功能，基于所评估的第二标准来选择多个测试用例的子集，以及测试所选择的多个软件的子集 使用多个测试用例的所选子集的组件。

公开(公告)号：US09060847B2

公开(公告)日：2015-06-23

申请号：US12380892

申请日：2009-03-04

Applicant: Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

Inventor： Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

IPC: B05D3/06 ,  A61L27/50 ,  A61L27/52 ,  A61F9/008 ,  B29D11/00 ,  A61F2/16

CPC classification number: A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.

公开(公告)号：US08759759B2

公开(公告)日：2014-06-24

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/00

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US08704170B2

公开(公告)日：2014-04-22

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/24 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US20130335424A1

公开(公告)日：2013-12-19

申请号：US13985834

申请日：2012-12-20

Applicant: Xiaolei Wang ,  Lei Zhang ,  Li Ding

Inventor： Xiaolei Wang ,  Lei Zhang ,  Li Ding

IPC: G06T11/60

CPC classification number: G06T11/60 ,  G06T11/203 ,  G09G5/28 ,  G09G2320/02 ,  G09G2360/16

Abstract: A character display technique relating to computer information processing to improve the display of characters. Whether a thickening process on a glyph outline corresponding to a character to be displayed is needed is determined by calculating a mean grayscale value of pixels of a grayscale bitmap of the glyph outline. if thickening is to be performed, the thickening amount is determined on the basis of the mean grayscale value of pixels, and the thickened glyph outline is output for display, thereby minimizing problems of fading of the displayed color, fuzzy strokes and the like due to strokes that are too narrow, and thus improving the character display effect.

Abstract translation: 与计算机信息处理相关的字符显示技术，以改善字符的显示。 通过计算字形轮廓的灰度位图的像素的平均灰度值来确定是否需要对应于要显示的字符的字形轮廓上的增稠处理。 如果要进行增厚，则基于像素的平均灰度值来确定增厚量，并且输出加粗的字形轮廓以进行显示，从而最小化由于显示的颜色，模糊笔画等引起的褪色的问题 笔画太窄，从而改善了人物的显示效果。

公开(公告)号：US20130187044A1

公开(公告)日：2013-07-25

申请号：US13357470

申请日：2012-01-24

Applicant: LI DING ,  GONGYU JIANG ,  WENJIAN SUN

Inventor： LI DING ,  GONGYU JIANG ,  WENJIAN SUN

IPC: H01J49/22

CPC classification number: H01J49/065 ,  H01J49/066

Abstract: This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.

Abstract translation: 本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。 这些线电极沿离子导向装置中限定的离子引导轴分布。 每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。 离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。 电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。

公开(公告)号：US20120310340A1

公开(公告)日：2012-12-06

申请号：US13238143

申请日：2011-09-21

Applicant: Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

Inventor： Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

IPC: A61F2/16 ,  B29D11/00

CPC classification number: G02B3/0087 ,  A61F2/1618 ,  A61F2/1627 ,  A61F9/00834 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/18 ,  A61L2430/16 ,  G02B2003/0093 ,  G02C2202/12 ,  G02C2202/14 ,  C08L33/10

Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

Abstract translation: 一种用于改变光学聚合物材料的折射率的方法。 该方法包括用飞秒激光脉冲连续照射光学聚合材料的预定区域，以在材料内形成梯度折射率折射结构。 光学装置包括具有前表面和后表面的光学聚合物透镜材料和与表面相交的光轴以及设置在前表面和后表面之间并且沿着第一轴线45布置的至少一个激光修饰的GRIN层 °至90°，并且进一步的特征在于，相邻段的至少一部分中的至少一个和沿着每个段的折射率的变化。

公开(公告)号：US20120229313A1

公开(公告)日：2012-09-13

申请号：US13232442

申请日：2011-09-14

Applicant: Sai-Weng SIN ,  He-Gong WEI ,  Franco MALOBERTI ,  Li DING ,  Yan ZHU ,  Chi-Hang CHAN ,  U-Fat CHIO ,  Seng-Pan U ,  Rui Paulo da Silva MARTINS

Inventor： Sai-Weng SIN ,  He-Gong WEI ,  Franco MALOBERTI ,  Li DING ,  Yan ZHU ,  Chi-Hang CHAN ,  U-Fat CHIO ,  Seng-Pan U ,  Rui Paulo da Silva MARTINS

IPC: H03M1/12

CPC classification number: H03M1/1225 ,  H03M1/0695 ,  H03M1/1215 ,  H03M1/164 ,  H03M1/468

Abstract: The present invention provides an analog-to-digital converter (ADC) circuit comprising two time-interleaved successive approximation register (SAR) ADCs. Each of the two time-interleaved SAR ADCs comprises a first stage SAR sub-ADC, a residue amplifier, a second stage SAR sub-ADC and a digital error correction logic. The residue amplifier is shared between the time-interleaved paths, has a reduced gain and operates in sub-threshold to achieve power effective design

Abstract translation: 本发明提供一种包括两个时间交错的逐次逼近寄存器（SAR）ADC的模数转换器（ADC）电路。 两个时间交织的SAR ADC中的每一个包括第一级SAR子ADC，残差放大器，第二级SAR子ADC和数字纠错逻辑。 剩余放大器在时间交织路径之间共享，具有减小的增益并且在子阈值中操作以实现功率有效设计