公开(公告)号：US20230381743A1

公开(公告)日：2023-11-30

申请号：US18338633

申请日：2023-06-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Eduardo Silvestre ,  Stephan Hug

IPC: B01J20/28 ,  B01J20/26 ,  B01J20/32 ,  B03C1/01 ,  G01N33/543

CPC classification number: B01J20/28009 ,  B01J20/267 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B03C2201/26 ,  B01J20/3272 ,  B03C1/01 ,  G01N33/54326 ,  B01J20/3282 ,  B01J20/3293 ,  B03C2201/18 ,  B01J20/3234

Abstract: The present disclosure relates to a method of preparing a magnetic particle having a polymer matrix (P) and at least one magnetic core (M), preferably at least two magnetic cores (M), wherein the polymer matrix (P) comprises at least one hypercrosslinked polymer, wherein the method comprises (i) providing at least one magnetic core (M), preferably at least two magnetic cores (M), (ii) providing polymer precursor molecules, (iii) polymerizing the polymer precursor molecules according to (ii) in the presence of the at least one magnetic core (M), thereby forming a particle comprising the at least one magnetic core (M). Further, the present disclosure relates to particles obtained or obtainable by this method as well as to the use of these particles. In a further aspect, the disclosure relates to a method for determining at least one analyte in a fluid sample having the step of contacting of the magnetic particle with a fluid sample having or suspected of having the at least one analyte.

公开(公告)号：US20230324398A1

公开(公告)日：2023-10-12

申请号：US17990903

申请日：2022-11-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Uwe Kobold ,  Hannes Kuchelmeister ,  Heribert Maerz ,  Giuseppe Prencipe ,  Martin Rempt

IPC: G01N33/58

CPC classification number: G01N33/58 ,  G01N2560/00

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

公开(公告)号：US11774395B2

公开(公告)日：2023-10-03

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20230296623A1

公开(公告)日：2023-09-21

申请号：US18017073

申请日：2021-07-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Torbjoern Omland ,  Ursula-Henrike Wienhues-Thelen ,  Andre Ziegler

IPC: G01N33/68 ,  G01N33/569

CPC classification number: G01N33/6893 ,  G01N33/56983 ,  G01N2800/56

Abstract: The present invention relates to a method for predicting the disease severity in a patient with COVID-19, said method comprising a) determining the level of GDF-15 in a sample from the patient with COVID-19, b) comparing the level determined in step a) to a reference, and predicting the disease severity in a patient with COVID-19. Also encompassed are methods for risk stratification, monitoring of the disease progression and the risk prediction for hospital admission in a patient with COVID-19. Furthermore, methods are provided for predicting the need for intensive care, the risk for thrombosis, pulmonary embolism, hypoxia and mortality in a patient with COVID-19.

公开(公告)号：US11754431B2

公开(公告)日：2023-09-12

申请号：US17660966

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy

IPC: G01F23/292 ,  G01N15/04 ,  G01N15/05 ,  G01N35/04

CPC classification number: G01F23/2921 ,  G01N15/042 ,  G01N15/05 ,  G01N35/04 ,  G01N2015/045 ,  G01N2035/0493

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

公开(公告)号：US11747377B2

公开(公告)日：2023-09-05

申请号：US17075303

申请日：2020-10-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson

IPC: G01R27/14 ,  G01R31/36

CPC classification number: G01R27/14 ,  G01R31/3648

Abstract: A method for determining system resistance of at least one power supply of a handheld medical device, the method including: a) generating at least one excitation voltage signal, wherein the excitation voltage signal comprises at least one direct current (DC) voltage signal, wherein the excitation voltage signal has a fast transition DC flank of 20 ns or less; b) applying the excitation voltage signal to at least one reference resistor having a predetermined or pre-defined resistance value, wherein the reference resistor is arranged in series with the power supply; c) measuring a response signal of the power supply; d) determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and e) determining the system resistance of the power supply from the ohmic signal portion.

公开(公告)号：US11747354B2

公开(公告)日：2023-09-05

申请号：US17211113

申请日：2021-03-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Goran Savatic

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N35/00623 ,  G01N2035/00752

Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.

公开(公告)号：US11743239B2

公开(公告)日：2023-08-29

申请号：US17151950

申请日：2021-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Suter ,  Alejandro Morcillo Montejo ,  Antonio Tienda Fernandez ,  Stephen Martin

IPC: H04L9/40 ,  H04W12/033 ,  H04L67/561 ,  H04L67/565 ,  G06F21/62 ,  G16H10/60 ,  G16H40/67 ,  A61B5/00 ,  G16H40/20 ,  H04L9/08 ,  H04L9/14 ,  H04L9/30 ,  H04L69/08

CPC classification number: H04L63/0442 ,  A61B5/0022 ,  G16H10/60 ,  G16H40/20 ,  G16H40/67 ,  H04L9/0825 ,  H04L9/0866 ,  H04L9/14 ,  H04L9/30 ,  H04L63/0478 ,  H04L67/561 ,  H04L67/565 ,  H04W12/033 ,  A61B5/00 ,  G06F21/6245 ,  H04L63/0471 ,  H04L69/08

Abstract: A method for processing data of an analytical instrument for analyzing biological samples is presented. The method comprises receiving instrument data from the analytical instrument at a data processing module communicatively connected with the analytical instrument, generating metadata from the received instrument data at the data processing module, applying a first encryption to the instrument data at the data processing module, applying a second encryption to the generated metadata at the data processing module, and transmitting the encrypted metadata and encrypted instrument data to a remote server. The remote server and the data processing module are communicatively connected. The method also comprises removing the second encryption from the metadata at the remote server and forwarding the instrument data encrypted by the first encryption from the remote server to a management system of the analytical instrument.

公开(公告)号：US11740254B2

公开(公告)日：2023-08-29

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro Ota ,  Takaaki Hagiwara ,  Yoshihiro Yamashita ,  Koshin Hamasaki ,  Michaela Windfuhr ,  Heike Guggemos ,  Johannes Stoeckel ,  Guenter Ziegler ,  Michael Kuehnl

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  G01N35/1016 ,  G01N2035/1025

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US11726044B2

公开(公告)日：2023-08-15

申请号：US16739236

申请日：2020-01-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reinhold Kraemer ,  Michael Kuehnl ,  Uwe Mertsch ,  Marion Borchers

IPC: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N21/84

CPC classification number: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N2021/4726 ,  G01N2021/8411 ,  G01N2458/30

Abstract: A method of monitoring detection of an analyte in a liquid sample using a measuring cell, the measuring cell comprising a working electrode for excitation of electrochemiluminescence in the liquid sample, an optical detector for detecting the excited electrochemiluminescence, the excitation and detection being performed in an measurement cycle, the measurement cycle comprising transporting the liquid sample via a transport path to the working electrode using a support liquid, the method comprising: coupling light of a light source into the transport path during part of the measurement cycle, the transport path forming a light guide between the light source and the optical detector, detecting the coupled light by the optical detector, analyzing the detected light for a gas bubble in the transport path, providing a measurement state if the result of the analysis deviates from a target state regarding the presence of a gas bubble in the transport path.