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公开(公告)号：US12083108B2
公开(公告)日：2024-09-10
申请号：US17752683
申请日：2022-05-24
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Jonathan Bard , Matthew R. Lee , Longbin Liu , Michael Edward Prime , Samuel Coe
IPC: A61K31/454 , A61K31/165 , A61K31/427 , A61K47/54
CPC classification number: A61K31/454 , A61K31/165 , A61K31/427 , A61K47/555
Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
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公开(公告)号：US12036292B2
公开(公告)日：2024-07-16
申请号：US17395055
申请日：2021-08-05
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Celia Dominguez , Xuemei Chen , John E. Mangette
IPC: A61K51/04 , C07D239/28 , C07D401/12 , C07D401/14 , C07D403/06 , C07D471/04
CPC classification number: A61K51/0459 , C07D239/28 , C07D401/12 , C07D401/14 , C07D403/06 , C07D471/04 , C07B2200/05
Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11806346B2
公开(公告)日：2023-11-07
申请号：US17318693
申请日：2021-05-12
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Elizabeth M. Doherty , Longbin Liu , Matthew Lee , Mark Stuart Chambers , Karine Fabienne Malagu , Perla Breccia , Alan F. Haughan , Huw D. Vater , Andrew J. Stott , William R. K. Esmieu , Stephen John Webster , Amanda J. Van De Poël
IPC: A61K31/497 , A61P25/28 , A61K31/4985 , A61K31/501 , A61K31/506 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
CPC classification number: A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61P25/28 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US20230159531A1
公开(公告)日：2023-05-25
申请号：US17988340
申请日：2022-11-16
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Celia Dominguez , Nikolay V. Plotnikov , Alan Haughan , Andrew Stott , Brett Cosgrove , Cole Clissold , Huw Vater , Jonathan Spencer , William Esmieu , Karine Malagu , Mark Chambers
IPC: C07D471/10 , C07D413/14 , C07D405/14 , C07D403/14 , C07D471/04 , A61K45/06
CPC classification number: C07D471/10 , C07D413/14 , C07D405/14 , C07D403/14 , C07D471/04 , A61K45/06
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US20220388998A1
公开(公告)日：2022-12-08
申请号：US17621567
申请日：2020-06-26
Applicant: CHDI Foundation, Inc
Inventor： Michel C. Maillard , Matthew R. Lee , Celia Dominguez , Michael Barnes , Alan F. Haughan , Tammy Ladduwahetty , Christopher A. Luckhurst , Andrew J. Stott , Jason Tierney
IPC: C07D413/14 , C07D401/04 , C07D405/14 , C07D471/04 , C07D213/75 , C07D487/04 , C07D487/08
Abstract: Provided herein are certain inhibitors of ROCK (rho-kinases or rho-associated kinases), which are useful as medicament, for the treatment Huntington's disease in particular.
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Patent Agency Ranking
公开(公告)号：US11344637B2
公开(公告)日：2022-05-31
申请号：US16987277
申请日：2020-08-06
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20210188827A1
公开(公告)日：2021-06-24
申请号：US17111307
申请日：2020-12-03
Applicant: CHDI Foundation, Inc.
Inventor： Leticia M. Toledo-Sherman , Celia Dominguez , Perla Breccia , Amanda J. Van De Poël , Grant Wishart , Huw D. Vater , William R. K. Esmieu , Cole Clissold , Wesley P. Blackaby
IPC: C07D413/14 , C07D471/08 , C07D498/08
Abstract: Provided are certain ATM kinase inhibitors of Formula I: Also provided herein are compositions of such compounds, and methods of their use.
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48.发明授权公开(公告)号：US10428054B2
公开(公告)日：2019-10-01
申请号：US15851434
申请日：2017-12-21
Applicant: CHDI Foundation, Inc.
Inventor： Leticia M. Toledo-Sherman , Celia Dominguez , Michael Prime , William Mitchell , Naomi Went
IPC: A61K31/517 , A61K31/495 , A61K31/47 , A61K31/425 , A61K31/42 , A61K31/415 , A61K31/34 , C07D413/12 , C07D215/18 , C07D319/18 , C07D333/06 , C07D241/42 , C07D277/24 , C07D277/64 , C07D213/46 , C07D307/79 , C07D209/08 , C07D217/02 , C07D231/56 , C07D235/08 , C07D237/28 , C07D239/74 , C07D261/20 , C07D263/56 , C07D333/10 , C07D333/28 , C07D407/12 , A61K31/428 , A61K31/416 , A61K31/343 , A61K31/423 , A61K31/4184 , A61K31/502
Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
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公开(公告)号：US20190202795A1
公开(公告)日：2019-07-04
申请号：US16046254
申请日：2018-07-26
Applicant: CHDI Foundation, Inc.
Inventor： Michel C. Maillard , Perla Breccia , Celia Dominguez , Alan F. Haughan , Amanda Van de Poël , Andrew J. Stott , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Grant Wishart , Michael Wall , Rebecca E. Jarvis
IPC: C07D271/06 , C07D413/12 , C07D471/04
CPC classification number: C07D271/06 , C07D413/12 , C07D471/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US10106535B2
公开(公告)日：2018-10-23
申请号：US15482327
申请日：2017-04-07
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC: C07D471/04 , C07C259/08 , C07D277/64 , C07D231/12 , C07D231/56 , C07D261/20 , C07D241/12 , C07D239/26 , C07D213/61 , C07D333/60 , C07D275/04 , C07D213/64 , C07D277/62 , C07D241/42 , C07D213/56
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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