公开(公告)号：US20240410824A1

公开(公告)日：2024-12-12

申请号：US18442090

申请日：2024-02-14

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji QI ,  Jun TIAN ,  Wu CHOU ,  Hongbing LI

IPC: G01N21/31 ,  G01N21/03

Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.

公开(公告)号：US20240253049A1

公开(公告)日：2024-08-01

申请号：US18539222

申请日：2023-12-13

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji QI ,  Yufan ZHANG

IPC: B01L3/00 ,  G01N21/03 ,  G01N21/84 ,  G01N33/543

CPC classification number: B01L3/50853 ,  B01L3/5088 ,  G01N21/03 ,  G01N21/84 ,  G01N33/543 ,  G01N33/54366 ,  B01L2300/04 ,  B01L2300/0609 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0861

Abstract: The present invention, among other things, provides the devices and methods in manipulate a sample for the purpose of assaying.

公开(公告)号：US20240246073A1

公开(公告)日：2024-07-25

申请号：US18387006

申请日：2023-11-03

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Hua TAN ,  Wei DING ,  Yanjun WANG

IPC: B01L3/00

CPC classification number: B01L3/5023 ,  B01L2300/069 ,  B01L2300/0816

Abstract: The disclosure provides a device and a method to press a QMAX-Card to form a liquid layer. A device comprises a first arm including a pressing block and a second arm including a compartment for accommodating the QMAX-Card. Each of the first arm and the second arm comprises a first end and a second end opposing the first end, and the first arm and the second arm are joined by a hinge at the first end. The first arm is capable of rotating around the hinge toward the second arm 500 from an open position to a close position. The pressing block and the compartment face each other and are disposed at the second end. The pressing block press the QMAX-Card so that the QMAX-Card changes a closed configuration to compress a liquid sample in the QMAX-Card into a substantially uniform thin layer.

公开(公告)号：US20240175801A1

公开(公告)日：2024-05-30

申请号：US18505118

申请日：2023-11-09

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji QI ,  Jun Tian ,  Wu Chou

IPC: G01N21/03 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49

CPC classification number: G01N21/0303 ,  G01N1/2813 ,  G01N21/25 ,  G01N21/6458 ,  G01N33/49 ,  G01N2021/035 ,  G01N2021/6439 ,  G01N2201/0221

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US20240151736A1

公开(公告)日：2024-05-09

申请号：US18411418

申请日：2024-01-12

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Hua TAN ,  Yanjun WANG ,  Wei DING

IPC: G01N35/00 ,  G01N35/02

CPC classification number: G01N35/00069 ,  G01N35/021 ,  G01N2035/00148

Abstract: The disclosure provides an apparatus for high throughput analysis of samples and a method of making an assay card and performing an assay using the apparatus. The apparatus can include a transporter to position and advance a first plate of the QMAX card, a first dispenser to deposit a sample on the first plate, a second dispenser to dispense a reagent to contact the sample, a press to compress the sample between the first and second plates of the QMAX card into a uniformly thick layer, and an imager to image the uniformly thick layer.

公开(公告)号：US20240085304A1

公开(公告)日：2024-03-14

申请号：US18272777

申请日：2022-01-18

Applicant: Essenlix Corporation

Inventor： Xing LI ,  Wu CHOU ,  Stephen Y. CHOU ,  Wei DING ,  Ji QI

IPC: G01N15/14 ,  G06N3/0475 ,  G06T7/00 ,  G06V20/69

CPC classification number: G01N15/14 ,  G06N3/0475 ,  G06T7/0012 ,  G06V20/69 ,  G01N2015/0073

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

公开(公告)号：US20240042428A1

公开(公告)日：2024-02-08

申请号：US18265494

申请日：2021-12-07

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING

IPC: B01L3/00 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64

CPC classification number: B01L3/5027 ,  B01L3/5088 ,  B01L3/527 ,  G01N1/2813 ,  G01N21/251 ,  G01N21/6486 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/086

Abstract: A device for liquid sample collection and liquid sample analysis, including: a base plate having: at least one pedestal area in at least a portion of a sample image area; and at least one recessed area, wherein at least of a portion of the at least one pedestal area is adjacent to the at least one recessed area; a cover plate that opposes the base plate; a plurality of spacers attached to one of the base plate, the cover plate, or both, and the spacers are situated between the opposable plates; and an exterior liquid sample contact area on an exterior location of the device; wherein the base plate and the cover plate define an interior cavity in fluid communication with the exterior liquid sample contact area. Also disclosed are an apparatus including the device, a method of making the device, and a method of using the device.

公开(公告)号：US20240035954A1

公开(公告)日：2024-02-01

申请号：US18141996

申请日：2023-05-01

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Wu CHOU ,  Jun TIAN ,  Yuecheng ZHANG ,  Mingquan WU ,  Xing LI

IPC: G01N15/14 ,  G06N20/00 ,  G01N1/28 ,  G06N3/08 ,  G06T1/00

CPC classification number: G01N15/1484 ,  G06N20/00 ,  G01N1/2813 ,  G06N3/08 ,  G06T1/0014 ,  G01N2001/282

Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.

公开(公告)号：US20230350176A1

公开(公告)日：2023-11-02

申请号：US18218698

申请日：2023-07-06

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Wu CHOU ,  Ji QI ,  Jun TIAN ,  Yuecheng ZHANG ,  Mingquan WU

IPC: G02B21/00 ,  G06T7/90 ,  G06N20/00 ,  G01J3/52 ,  H04N23/51 ,  H04N23/55

CPC classification number: G02B21/0008 ,  G06T7/90 ,  G06N20/00 ,  G01J3/524 ,  G02B21/0032 ,  H04N23/51 ,  H04N23/55

Abstract: Disclosed is an apparatus and method for imaging: a side-view of a object on a surface, a Contact Angle of a liquid object, the color of an object, or combinations thereof.

公开(公告)号：US20230078489A1

公开(公告)日：2023-03-16

申请号：US17975537

申请日：2022-10-27

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING

IPC: G01N33/543 ,  G01N1/28 ,  G16B25/00 ,  G16B50/00 ,  G16H80/00 ,  B01L3/00 ,  G01N1/30 ,  G01N33/50

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g., 0.5 μL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.