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41.发明申请ASSAY BUFFER, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME 有权测定缓冲剂，含有该组合物的组合物及其使用方法公开(公告)号：US20090170121A1
公开(公告)日：2009-07-02
申请号：US12368742
申请日：2009-02-10
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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42.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07491540B2
公开(公告)日：2009-02-17
申请号：US11055472
申请日：2005-02-09
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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43.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07288410B2
公开(公告)日：2007-10-30
申请号：US11054672
申请日：2005-02-09
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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公开(公告)号：US20060040276A1
公开(公告)日：2006-02-23
申请号：US10969222
申请日：2004-10-20
CPC分类号： B82Y30/00 , B82Y15/00 , B82Y40/00 , C07H21/04 , C12Q1/6837 , G01N33/54353 , G01N33/54373 , G01N33/553 , G01N2610/00
摘要： An article suitable for use as a biosensor includes a molecule of a formula X—R-Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
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公开(公告)号：US12013332B2
公开(公告)日：2024-06-18
申请号：US13435885
申请日：2012-03-30
申请人： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
发明人： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
IPC分类号： G01N21/05 , B01L3/00 , B01L7/00 , B01L9/00 , G01F23/02 , G01F23/292 , G01N1/10 , G01N21/03 , G01N21/69 , G01N21/76
CPC分类号： G01N21/05 , B01L3/5027 , G01F23/02 , G01F23/292 , G01N1/10 , G01N21/03 , G01N21/0303 , G01N21/69 , G01N21/76 , B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2200/147 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/027 , B01L2300/044 , B01L2300/0645 , B01L2300/0654 , B01L2300/0809 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/0487 , B01L2400/0672 , B01L2400/0683 , B01L2400/0688 , G01N2021/0346 , G01N2021/054 , Y10T137/0396 , Y10T137/8593
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US09731297B2
公开(公告)日：2017-08-15
申请号：US13343834
申请日：2012-01-05
申请人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
发明人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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47.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US08785201B2
公开(公告)日：2014-07-22
申请号：US12368742
申请日：2009-02-10
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
摘要翻译： 本发明涉及使用磷酸化特异性抗体和基本上不含无机磷酸盐的缓冲组合物的磷酸化肽或蛋白质的改进的电化学发光测定方法。
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公开(公告)号：US20130085075A1
公开(公告)日：2013-04-04
申请号：US13487640
申请日：2012-06-04
申请人： George Sigal
发明人： George Sigal
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/576 , G01N2800/085 , Y02A50/54
摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.
摘要翻译： 本发明涉及诊断患者肝脏疾病的方法，以及监测肝脏疾病进展的方法和/或监测治疗剂或方案的治疗方案的方法。 本发明还涉及与本文所述诊断方法有关的测定试剂盒。
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公开(公告)号：US20130040850A1
公开(公告)日：2013-02-14
申请号：US13642347
申请日：2011-04-18
申请人： George Sigal
发明人： George Sigal
IPC分类号： G01N33/569 , C40B30/04 , C12Q1/70 , G01N33/566 , G01N21/76 , G01N33/553 , G01N21/25 , G01N21/47 , G01N27/72 , G01N21/66 , C40B40/10 , C12M1/34 , G01N33/53 , G01N21/64
CPC分类号： G01N33/56983 , G01N33/54313 , G01N33/566 , G01N2500/02
摘要： The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.
摘要翻译： 本发明提供了用于测量测试样品抑制由病原体表达的受体与病原体的宿主细胞配体的结合的能力的方法和试剂盒。
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公开(公告)号：US20120178091A1
公开(公告)日：2012-07-12
申请号：US13343834
申请日：2012-01-05
申请人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
发明人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
摘要翻译： 描述了具有净化，反应和检测区域以及可以包括样品室，废物室，导管，通风口，试剂室，重构室等的流体组分的测定盒。 测定盒用于进行多重核酸测量。 还描述了包括这种盒的试剂盒，使用它们的方法，以及配置成分析使用测定盒进行的分析的读取器。
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