公开(公告)号：US08780344B2

公开(公告)日：2014-07-15

申请号：US13384862

申请日：2009-10-01

申请人： Jing Tang ,  Wei Wu ,  Qiangfei Xia

发明人： Jing Tang ,  Wei Wu ,  Qiangfei Xia

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  G01N21/7743

摘要： Embodiments of the present invention are directed to systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy includes a waveguide layer configured with at least one array of features, and a material disposed on at least a portion of the features. Each array of features and the waveguide layer are configured to provide guided-mode resonance for at least one wavelength of electromagnetic radiation. The electromagnetic radiation produces enhanced Raman scattered light from analyte molecules located on or in proximity to the material.

摘要翻译： 本发明的实施例涉及用于进行表面增强拉曼光谱的系统。 在一个实施例中，用于执行拉曼光谱的系统包括配置有至少一个特征阵列的波导层和设置在特征的至少一部分上的材料。 每个特征阵列和波导层被配置为为至少一个波长的电磁辐射提供导模谐振。 电磁辐射产生来自位于材料上或附近的分析物分子的增强的拉曼散射光。

公开(公告)号：US08492428B2

公开(公告)日：2013-07-23

申请号：US12067158

申请日：2006-09-20

申请人： Yuan-Ping Pang ,  Jewn Giew Park ,  Jing Tang ,  Charles B. Millard ,  James J. Schmidt

发明人： Yuan-Ping Pang ,  Jewn Giew Park ,  Jing Tang ,  Charles B. Millard ,  James J. Schmidt

IPC分类号： A61K31/404 ,  C07D209/08 ,  C07D401/14 ,  C07D403/14

CPC分类号： A61K31/675

摘要： Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

摘要翻译： 提供了肉毒杆菌毒素的小分子抑制剂，包括BoNTA，BoNTD和BoNTE，以及使用抑制剂的方法。

公开(公告)号：US08060187B2

公开(公告)日：2011-11-15

申请号：US12123890

申请日：2008-05-20

申请人： Barbara J. Marshik-Geurts ,  Jing Tang ,  Andres Zuluaga

发明人： Barbara J. Marshik-Geurts ,  Jing Tang ,  Andres Zuluaga

IPC分类号： A61B6/00

CPC分类号： A61B5/0086 ,  A61B5/0075 ,  G06F19/00

摘要： The invention relates to methods and devices for characterizing tissue in vivo, e.g., in walls of blood vessels, to determine whether the tissue is healthy or diseased, and include methods of displaying results with or without thresholds.

摘要翻译： 本发明涉及用于表征体内组织的方法和装置，例如在血管壁中，以确定组织是健康还是患病，并且包括显示具有或不具有阈值的结果的方法。

公开(公告)号：US07939422B2

公开(公告)日：2011-05-10

申请号：US11947674

申请日：2007-11-29

申请人： Nitin K. Ingle ,  Jing Tang ,  Yi Zheng ,  Zheng Yuan ,  Zhenbin Ge ,  Xinliang Lu ,  Chien-Teh Kao ,  Vikash Banthia ,  William H. McClintock ,  Mei Chang

发明人： Nitin K. Ingle ,  Jing Tang ,  Yi Zheng ,  Zheng Yuan ,  Zhenbin Ge ,  Xinliang Lu ,  Chien-Teh Kao ,  Vikash Banthia ,  William H. McClintock ,  Mei Chang

IPC分类号： H01L21/76

CPC分类号： H01L21/67253 ,  H01L21/02164 ,  H01L21/0217 ,  H01L21/3105 ,  H01L21/31116 ,  H01L21/76232

摘要： A method for forming a semiconductor structure includes forming a plurality of features across a surface of a substrate, with at least one space being between two adjacent features. A first dielectric layer is formed on the features and within the at least one space. A portion of the first dielectric layer interacts with a reactant derived from a first precursor and a second precursor to form a first solid product. The first solid product is decomposed to substantially remove the portion of the first dielectric layer. A second dielectric layer is formed to substantially fill the at least one space.

摘要翻译： 一种用于形成半导体结构的方法包括跨越衬底的表面形成多个特征，其中至少一个空间位于两个相邻特征之间。 第一电介质层形成在特征上并且在至少一个空间内。 第一介电层的一部分与衍生自第一前体和第二前体的反应物相互作用以形成第一固体产物。 第一固体产物被分解以基本上除去第一介电层的部分。 形成第二电介质层以基本上填充至少一个空间。

公开(公告)号：US20100286531A1

公开(公告)日：2010-11-11

申请号：US12784482

申请日：2010-05-20

申请人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

发明人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

IPC分类号： A61B6/00

CPC分类号： A61B5/0086 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/6853 ,  A61B2017/22001 ,  A61N5/0601

摘要： A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm−1 and about 10 cm−1 when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.

摘要翻译： 一种用于分析体腔的系统，包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端; 至少一个输送波导和沿着柔性导管延伸的至少一个收集波导，所述至少一个输送波导的透射输出和沿着导管的远端部分定位的至少一个收集波导的透射输入; 光谱仪，其连接到所述至少一个传送波导和所述至少一个收集波导，所述光谱仪被配置为执行漫反射光谱，其中所述光谱仪发射具有约8cm -3的吸收系数的波长的至少一个初级辐射信号， 1和约10cm -1，当透过高含量介质时; 控制器系统，其被配置为基于由所述光谱仪通过所述高度水介质测量的所述至少一个主要辐射信号的吸收量来计算高度水介质的程度，面积和体积中的至少一个。

公开(公告)号：US20100265500A1

公开(公告)日：2010-10-21

申请号：US12425363

申请日：2009-04-16

申请人： Qiangfei Xia ,  Jing Tang

发明人： Qiangfei Xia ,  Jing Tang

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01N21/658

摘要： A structure for surface enhanced Raman spectroscopy is disclosed herein. The structure is made up of a substrate, a self-assembled layer of first metal particles established on the substrate, and a self-assembled layer of second metal particles established such that the second metal particles are positioned at interstitial spaces between the first metal particles. The first metal particles have a first predetermined diameter, and the second metal particles have a second predetermined diameter that is smaller than the first predetermined diameter.

摘要翻译： 本文公开了表面增强拉曼光谱的结构。 该结构由衬底，建立在衬底上的第一金属颗粒的自组装层和第二金属颗粒的自组装层构成，其被建立为使得第二金属颗粒位于第一金属颗粒之间的间隙处 。 第一金属颗粒具有第一预定直径，第二金属颗粒具有小于第一预定直径的第二预定直径。

公开(公告)号：US20100253940A1

公开(公告)日：2010-10-07

申请号：US12416907

申请日：2009-04-01

申请人： Qiangfei Xia ,  Wei Wu ,  Zhiyong Li ,  Jing Tang

发明人： Qiangfei Xia ,  Wei Wu ,  Zhiyong Li ,  Jing Tang

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  G01N2021/058 ,  Y10S977/712

摘要： A structure for surface enhanced Raman spectroscopy is disclosed herein. A substrate has a stack configured vertically thereon. The stack encompasses at least two metal layers and at least one dielectric layer therebetween. Each layer of the stack has a controlled thickness, and each of the at least two metal layers is configured to exhibit a predetermined characteristic of plasmonic resonance.

摘要翻译： 本文公开了表面增强拉曼光谱的结构。 衬底具有垂直地配置的堆叠。 堆叠包括至少两个金属层和其间的至少一个电介质层。 堆叠的每个层具有受控的厚度，并且所述至少两个金属层中的每一个被配置为表现出等离子体共振的预定特性。

公开(公告)号：US20100079754A1

公开(公告)日：2010-04-01

申请号：US12286490

申请日：2008-09-30

申请人： Huei Pei Kuo ,  Jing Tang ,  Alexandre M. Bratkovski ,  Theodore I. Kamins ,  Wei Wu ,  Michael Renne Ty Tan ,  Shih-Yuan Wang

发明人： Huei Pei Kuo ,  Jing Tang ,  Alexandre M. Bratkovski ,  Theodore I. Kamins ,  Wei Wu ,  Michael Renne Ty Tan ,  Shih-Yuan Wang

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0291 ,  G01N21/658 ,  G01N2021/651

摘要： Various embodiments of the present invention relate generally to systems for performing Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy comprises an analyte holder having a surface configured to retain an analyte and a light concentrator configured to receive an incident beam of light, split the incident beam into one or more beams, and direct the one or more beams to substantially intersect at the surface. The system may also include a collector configured to focus each of the one or more beams onto the surface, collect the Raman scattered light emitted from the analyte, and direct the Raman scattered light away from the surface.

摘要翻译： 本发明的各种实施方案一般涉及用于进行拉曼光谱的系统。 在一个实施例中，用于执行拉曼光谱的系统包括分析物保持器，其具有被配置为保持分析物的表面和被配置为接收入射光束的光聚集器，将入射光束分成一个或多个光束， 更多的光束在表面上基本相交。 该系统还可以包括集电器，其被配置为将一个或多个光束中的每一个聚焦到表面上，收集从分析物发射的拉曼散射光，并将拉曼散射光引导离开表面。

公开(公告)号：US20100069760A1

公开(公告)日：2010-03-18

申请号：US12561756

申请日：2009-09-17

申请人： Jing Tang

发明人： Jing Tang

IPC分类号： A61M37/00 ,  A61B6/00

CPC分类号： A61B5/0075 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007

摘要： A method and apparatus for analyzing and treating internal lumens is provided. The apparatus includes a catheterized device integrating an optical probe and local treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with visible and/or near infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with diseased lumens, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering localized treatments including stem cells, antibiotics, gene therapy, neoplasty, and sclerosant drugs, etc. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.

摘要翻译： 提供了一种用于分析和处理内部流明的方法和装置。 该装置包括集成光学探针和局部治疗递送系统的导管装置。 探针组件包括光纤线，其可以与可见光和/或近红外光谱结合使用以分析组织的各种特征，包括化学，血液和氧含量，以便定位与患病流明相关的那些组织，以确定 治疗的最佳位置，以及监测治疗及其效果。 与探针组分物理整合是用于传递局部治疗的治疗组件，包括干细胞，抗生素，基因治疗，成形术和硬化药物等。控制系统协调导管的操作，包括使用模型数据进行化学计量分析 并且用于向操作者提供控制和视觉反馈。

公开(公告)号：US20100049182A1

公开(公告)日：2010-02-25

申请号：US12520022

申请日：2007-12-21

申请人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

发明人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

IPC分类号： A61B18/18

CPC分类号： A61B5/0075 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/6853 ,  A61B18/24 ,  A61B2017/00274 ,  A61B2017/22051 ,  A61B2018/00547 ,  A61B2562/146

摘要： Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis. Additional applications include the deliver of therapeutic radiation externally and internally to tissues through h the solution media.

摘要翻译： 用于提供具有光学分析和治疗能量递送的流体和减毒光学介质的系统，方法和装置。 本发明的一个方面提供了约1％至35％之间的增加盐度的水溶液。 根据本发明的增加的盐度提供了许多波长的改进的透射效率和比许多现有的系统和方法更少的毒性。 具有用于探测或治疗内部腔或其他组织的集成纤维的导管可以包括使用溶液替代在纤维和靶组织之间的光路中的血液或其它障碍物的液体充气球囊或冲洗机构。 可以使用包括光谱学的方法用于诊断与患病血管或其他组织相关的医学病症的解决方案，同时降低由诊断引起的永久性损伤的风险。 其他应用包括通过溶液介质在组织外部和内部传递治疗辐射。