公开(公告)号：US06939692B2

公开(公告)日：2005-09-06

申请号：US09949970

申请日：2001-09-12

申请人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

发明人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

IPC分类号： C12N9/12 ,  C12P13/04

CPC分类号： C12N9/1205 ,  C12P13/04 ,  C12Y207/01037

摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

公开(公告)号：US20050095687A1

公开(公告)日：2005-05-05

申请号：US10937554

申请日：2004-09-10

申请人： Mechthild Rieping ,  Thomas Hermann ,  Mike Farwick

发明人： Mechthild Rieping ,  Thomas Hermann ,  Mike Farwick

IPC分类号： C07K14/245 ,  C12N1/21 ,  C12N15/31 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/12

CPC分类号： C12P13/04 ,  C07K14/245 ,  C12P13/06 ,  C12P13/08 ,  C12P13/12

摘要： The invention relates to a process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the family Enterobacteriaceae which produce the desired L-amino acid and in which the mglB gene, or nucleotide sequences coding therefor, is (are) enhanced and, in particular, overexpressed, b) enrichment of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid.

摘要翻译： 本发明涉及一种制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物的发酵，其中 mglB基因或其编码的核苷酸序列被增强，特别是过表达，b）在培养基中或细胞中富集所需的L-氨基酸，和c）分离所需的L -氨基酸。

公开(公告)号：US06822085B2

公开(公告)日：2004-11-23

申请号：US09962357

申请日：2001-09-26

申请人： Mike Farwick ,  Klaus Huthmacher ,  Natalie Schischka ,  Brigitte Bathe ,  Walter Pfefferle ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

发明人： Mike Farwick ,  Klaus Huthmacher ,  Natalie Schischka ,  Brigitte Bathe ,  Walter Pfefferle ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

IPC分类号： C07H2104

CPC分类号： C12N9/0051 ,  A23K10/12 ,  A23K20/142 ,  A23K40/10 ,  C12N9/1029 ,  C12N9/1241 ,  C12N9/88 ,  C12P13/08 ,  C12P13/12

摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.

摘要翻译： 来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法 使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针 以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

公开(公告)号：US20130071340A1

公开(公告)日：2013-03-21

申请号：US13701358

申请日：2011-04-27

申请人： Hans Henning Wenk ,  Juergen Meyer ,  Oliver Springer ,  Mike Farwick ,  Klaus Jenni ,  Wolfgang Berkels ,  Frank Unger

发明人： Hans Henning Wenk ,  Juergen Meyer ,  Oliver Springer ,  Mike Farwick ,  Klaus Jenni ,  Wolfgang Berkels ,  Frank Unger

IPC分类号： A61K8/92 ,  A61Q17/04 ,  C11C3/02 ,  A61K8/81 ,  A61K8/85

CPC分类号： A61K8/92 ,  A61K8/375 ,  A61Q17/04 ,  C07C69/30 ,  C07C69/33 ,  C07C69/78 ,  C11C3/003 ,  C11C3/02 ,  C11C3/025 ,  C11C3/06 ,  C11C3/08

摘要： The invention relates to polyol partial esters, cosmetic and pharmaceutical formulations containing the polyol partial esters according to the invention, and to the use of the polyol partial esters according to the invention for cosmetic and pharmaceutical purposes.

摘要翻译： 本发明涉及包含根据本发明的多元醇偏酯的多元醇偏酯，化妆品和药物制剂，以及根据本发明的多元醇偏酯用于化妆品和药物目的的用途。

公开(公告)号：US20100184733A1

公开(公告)日：2010-07-22

申请号：US12445365

申请日：2006-10-13

申请人： Cornelis Gerrit Nijs Korevaar ,  Mike Farwick ,  Juergen Meyer ,  Peter Lersch ,  Wilma Reidick ,  Christian Weitemeyer

发明人： Cornelis Gerrit Nijs Korevaar ,  Mike Farwick ,  Juergen Meyer ,  Peter Lersch ,  Wilma Reidick ,  Christian Weitemeyer

IPC分类号： A61K31/575 ,  A61P17/02

CPC分类号： A61K8/63 ,  A61K8/361 ,  A61K8/68 ,  A61K8/86 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

摘要： The invention discloses skin treatment compositions consisting essentially of a mixture of ceramides, cholesterol, free fatty acids—the mixture being able to mimic skin identical lamellar structures—and nonionic emulsifiers. These compositions are liquid and pumpable at room temperature which means that they can be incorporated easily into cosmetic formulations with no need for heating. Furthermore, the skin treatment compositions allow the stable inclusion of long-chain ceramides into oil-in-water emulsions as well as into water-in-oil emulsions. Inclusion of short chain ceramides that can act as dermatological regulators did not affect the lamellar lipid organization. The skin treatment compositions are claimed as well as their use in cosmetic and dermatological formulations.

摘要翻译： 本发明公开了皮肤治疗组合物，其基本上由神经酰胺，胆固醇，游离脂肪酸的混合物组成 - 混合物能够模拟皮肤相同的层状结构 - 和非离子乳化剂。 这些组合物在室温下是液体和可泵送的，这意味着它们可以容易地并入化妆品配方中而不需要加热。 此外，皮肤处理组合物允许将长链神经酰胺稳定地包含在水包油乳液中以及油包水乳液中。 包含可用作皮肤调节剂的短链神经酰胺不影响层状脂质组织。 要求皮肤治疗组合物以及它们在化妆品和皮肤病学制剂中的用途。

公开(公告)号：US20100136130A1

公开(公告)日：2010-06-03

申请号：US12596401

申请日：2008-04-15

申请人： Matthias Seiler ,  Martin Haneke ,  Henning Marckmann ,  Stephan Pilz ,  Muhammad Irfan ,  Saskia Klee-Laquai ,  Geoffrey Hills ,  Mike Farwick ,  Peter Lersch ,  Axel Kobus

发明人： Matthias Seiler ,  Martin Haneke ,  Henning Marckmann ,  Stephan Pilz ,  Muhammad Irfan ,  Saskia Klee-Laquai ,  Geoffrey Hills ,  Mike Farwick ,  Peter Lersch ,  Axel Kobus

IPC分类号： A61K36/736 ,  A61K9/14 ,  A61P43/00

CPC分类号： A61K36/00

摘要： The present invention relates to a preparation comprising at least one encapsulation material and at least one bioactive natural substance, which bioactive natural substance can be released from the preparation in a controlled manner, wherein the encapsulation material comprises at least one glyceride with a melting point of at least 35° C. and additionally at least one polymer with polyester units, which has a melting temperature of at least 30° C. and a viscosity in the range from 50 mPa*s to 250 Pa*s, measured by means of rotational viscometry at 110° C. The present invention further describes processes for producing the preparation of the invention, as well as preferred uses.

摘要翻译： 本发明涉及包含至少一种包封材料和至少一种生物活性天然物质的制剂，所述生物活性天然物质可以以受控的方式从所述制剂中释放，其中所述包封材料包含至少一种甘油酯，其熔点为 至少35℃，另外具有至少一种具有聚酯单元的聚合物，其具有至少30℃的熔融温度和在50mPa * s至250Pa * s范围内的粘度，其通过旋转 本发明还描述了制备本发明制剂的方法以及优选的用途。

公开(公告)号：US20080249073A1

公开(公告)日：2008-10-09

申请号：US12135462

申请日：2008-06-09

申请人： Mike Farwick ,  Anthony V. Rawlings

发明人： Mike Farwick ,  Anthony V. Rawlings

IPC分类号： A61K31/606 ,  A61P17/00

CPC分类号： A61Q19/08 ,  A61K8/41 ,  A61K8/68 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/06

摘要： This invention relates to a cosmetic composition comprising: a) Salicyloyl-sphingoidbases and/or derivatives thereof and b) a dermatologically acceptable carrier for treating and/or preventing cellulitic skin by increasing dermal structural proteins (collagen and fibrillin) and reducing the levels of MMP-1 activity.

摘要翻译： 本发明涉及化妆品组合物，其包含：a）水杨基 - 类鞘氨醇碱和/或其衍生物，和b）通过增加皮肤结构蛋白（胶原和纤维蛋白）并降低MMP的水平来治疗和/或预防纤维素皮肤的皮肤病学可接受的载体 -1活动。

公开(公告)号：US20080145320A1

公开(公告)日：2008-06-19

申请号：US11939876

申请日：2007-11-14

申请人： Hans Henning Wenk ,  Petra Allef ,  Stefan Bergfried ,  Mike Farwick ,  Burghard Gruning

发明人： Hans Henning Wenk ,  Petra Allef ,  Stefan Bergfried ,  Mike Farwick ,  Burghard Gruning

IPC分类号： A61K8/44 ,  C07C235/00 ,  A01N37/18 ,  A61Q15/00 ,  A61P17/10 ,  A61Q11/00 ,  A01P1/00 ,  A61K31/164

CPC分类号： A61Q11/00 ,  A01N37/36 ,  A61K8/42 ,  A61K8/45 ,  A61K8/86 ,  A61Q5/006 ,  A61Q15/00 ,  A61Q19/00 ,  C07C235/06

摘要： Compounds of the general formula and to the use thereof for controlling microorganisms are provided.

摘要翻译： 提供通式的化合物及其用于控制​​微生物的用途。

公开(公告)号：US07226763B2

公开(公告)日：2007-06-05

申请号：US11110837

申请日：2005-04-21

申请人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

发明人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

IPC分类号： C12P13/04 ,  C12N9/10 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N9/1205 ,  C12R1/15

摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

摘要翻译： 一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b） 编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状杆菌制备L-氨基酸的发酵方法，其中至少pknD基因是 扩增和使用含有本发明序列的多核苷酸作为杂交探针。

公开(公告)号：US07205131B2

公开(公告)日：2007-04-17

申请号：US10916437

申请日：2004-08-12

申请人： Mike Farwick ,  Bettina Möckel ,  Walter Pfefferle

发明人： Mike Farwick ,  Bettina Möckel ,  Walter Pfefferle

IPC分类号： C12P13/04 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/04

CPC分类号： C12N9/1205 ,  C12P13/04 ,  C12P13/08

摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no.2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids with enhancement of the ptsH gene coding for component H of the phosphotransferase system, and the use of the above polynucleotides as primer or hybridisation probe.

摘要翻译： 本发明涉及含有选自组合的多核苷酸序列的分离的多核苷酸