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41.发明申请Laminous Vascular Constructs Combining Cell Sheet Engineering And Electrospinning Technologies 审中-公开结合细胞板工程和静电纺丝技术的层状血管构造公开(公告)号：US20150112419A1
公开(公告)日：2015-04-23
申请号：US14518352
申请日：2014-10-20
Applicant: Wake Forest University Health Sciences
Inventor： Hyunhee Ahn , Young Min Ju , Anthony Atala , Sang Jin Lee
CPC classification number: A61L27/507 , A61F2/06 , A61F2/062 , A61F2/07 , A61F2210/0076 , A61F2240/001 , A61L27/26 , A61L27/3808 , A61L27/3826 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01D5/0007 , C08L67/04 , C08L89/06
Abstract: Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
Abstract translation: 血管支架及其制造方法被公开用于血管构造的组织工程。 通过将静电纺丝基质与细胞片技术相结合，可以获得具有更成熟细胞层的血管构造物用于重建血管，心脏瓣膜等。 围绕电纺丝血管支架的工程化平滑肌细胞片能够提供表达强的细胞 - 细胞连接标记物和收缩蛋白质的成熟的SMC层。 此外，细胞膜覆盖的血管支架的预处理保持细胞活力并渗入支架。
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公开(公告)号：US20140371869A1
公开(公告)日：2014-12-18
申请号：US14256643
申请日：2014-04-18
Applicant: Wake Forest University Health Sciences
Inventor： Anthony Atala , James J. Yoo , Grace Lim , Sang Jin Lee
CPC classification number: A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
Abstract translation: 本发明涉及生产允许协调运动的人造复合组织结构的方法。 使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。 用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协调运动的人造复合组织构建体。
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公开(公告)号：US20140242125A1
公开(公告)日：2014-08-28
申请号：US14239416
申请日：2012-08-15
Applicant: Wake Forest University Health Sciences
Inventor： Anthony Atala , James Yoo , In Kap Ko
CPC classification number: A61L27/3604 , A61K9/0034 , A61K35/34 , A61K38/18 , A61K45/06 , A61K47/34 , A61K47/42 , A61L27/18 , A61L27/24 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/30 , C12N5/0062 , C12N5/0659 , C12N2513/00 , C12N2533/30 , C12N2533/54 , A61K2300/00 , C08L67/04
Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
Abstract translation: 本发明涉及用于获得用于移植的均匀尺寸的肌纤维片段的方法和组合物。 这些肌纤维碎片能够重建成沿着原生肌肉定向的长纤维。 植入的肌肉细胞与天然血管和神经网络结合，如组织学和免疫组织化学所证实的。 本发明是特别有利的，因为可以从供体部位收获自体肌肉，将其加工并注射到手术室中的靶位点。 碎片肌肉纤维可以容易地集成在宿主内。
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公开(公告)号：US20230372637A1
公开(公告)日：2023-11-23
申请号：US18364567
申请日：2023-08-03
Applicant: Wake Forest University Health Sciences
Inventor： James J. Yoo , Anthony Atala , Kyle W. Binder , Mohammad Z. Albanna , Weixin Zhao , Dennis Dice , Tao Xu
IPC: A61M11/00 , A61B5/00 , A61B5/107 , A61L27/22 , A61L27/24 , A61L27/38 , A61L27/60 , C12N5/077 , A61M35/00
CPC classification number: A61M11/00 , A61B5/6835 , A61B5/1077 , A61B5/1079 , A61B5/445 , A61B5/0064 , A61L27/225 , A61L27/24 , A61L27/3813 , A61L27/60 , C12N5/0656 , A61M35/20 , B41J3/4073
Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
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公开(公告)号：US11801327B2
公开(公告)日：2023-10-31
申请号：US17237116
申请日：2021-04-22
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: A61L27/20 , A61L27/22 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/112 , B29C64/124 , B29C64/393 , B33Y70/00 , C12M3/00 , C12M1/00 , C12M1/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y80/00 , B29K105/00 , B29K267/00 , B29L31/00
CPC classification number: A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/112 , B29C64/124 , B29C64/393 , B33Y70/00 , A61K35/12 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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Patent Agency Ranking
公开(公告)号：US11786581B2
公开(公告)日：2023-10-17
申请号：US17105156
申请日：2020-11-25
Applicant: Wake Forest University Health Sciences
Inventor： James Yoo , Sang Jin Lee , Anthony Atala , Mark Van Dyke
CPC classification number: A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K38/39 , A61K2300/00 , A61K38/4886 , A61K2300/00
Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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公开(公告)号：US20210252188A1
公开(公告)日：2021-08-19
申请号：US17237116
申请日：2021-04-22
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: A61L27/20 , B29C64/393 , B29C64/112 , A61L27/22 , A61L27/38 , A61L27/52 , B29C64/124 , A61L27/26
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US20210222131A1
公开(公告)日：2021-07-22
申请号：US17224191
申请日：2021-04-07
Applicant: Wake Forest University Health Sciences
Inventor： Sean V. Murphy , Anthony Atala
Abstract: Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and/or between said stromal cell layer and said endothelial lung cell layer.
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公开(公告)号：US20200345899A1
公开(公告)日：2020-11-05
申请号：US16947053
申请日：2020-07-16
Applicant: Wake Forest University Health Sciences
Inventor： Anthony Atala , Gayoung Jeong , James J. Yoo , Sang Jin Lee , Young-Joon Seol
IPC: A61L27/60 , A61F2/10 , B33Y80/00 , B33Y70/00 , C08L5/08 , A61L27/20 , C08L89/06 , C12N5/071 , B33Y10/00 , A61L27/18 , A61L27/38 , A61L27/52 , G01N33/50
Abstract: Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics.
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公开(公告)号：US10537689B2
公开(公告)日：2020-01-21
申请号：US16158808
申请日：2018-10-12
Applicant: Wake Forest University Health Sciences
Inventor： James J. Yoo , Anthony Atala , Kyle W. Binder , Mohammad Z. Albanna , Weixin Zhao , Dennis Dice , Tao Xu
IPC: A61M5/178 , A61M11/00 , A61B5/00 , A61B5/107 , A61M35/00 , A61L27/22 , A61L27/24 , A61L27/38 , A61L27/60 , C12N5/077 , A61M1/00 , A61M5/00 , A61M5/315 , A61M27/00 , B41J3/407 , A61B17/00 , A61B17/322 , A61B90/50 , A61B34/30 , A61B34/10
Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
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