专利检索 ap:("Ying-Zi Xu" OR "Dean R. Artis" OR "Simeon Bowers" OR "Roy K. Hom" OR "Hing L. Sham" OR "Shendong Yuan") AND inv:"Hing L. Sham" 第 5 页

41.

发明授权
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译：药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂

公开(公告)号：US07238724B2

公开(公告)日：2007-07-03

申请号：US11036258

申请日：2005-01-13

申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong

发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong

IPC分类号： A61K31/40 , A61K31/401 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D401/12 , C07D211/58 , C07D239/42

CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12

摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.

摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物。

42.

发明授权
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor 有权

公开(公告)号：US07049307B2

公开(公告)日：2006-05-23

申请号：US11020464

申请日：2004-12-22

申请人： Andrew J. Souers , Christine A. Collins , Ju Gao , Andrew S. Judd , Philip R. Kym , Mathew M. Mulhern , Hing L. Sham , Dariusz Wodka

发明人： Andrew J. Souers , Christine A. Collins , Ju Gao , Andrew S. Judd , Philip R. Kym , Mathew M. Mulhern , Hing L. Sham , Dariusz Wodka

IPC分类号： A61K31/55 , A61K31/416 , A61K31/5377 , A61K31/438 , A61K31/454

CPC分类号： C07D403/06 , C07D231/56 , C07D401/06 , C07D403/04 , C07D405/06 , C07D491/10

摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

43.

发明授权
Protein kinase inhibitors 有权
标题翻译：蛋白激酶抑制剂

公开(公告)号：US06797825B2

公开(公告)日：2004-09-28

申请号：US10317336

申请日：2002-12-12

申请人： Nan-Horng Lin , Hing L. Sham , Ping Xia

发明人： Nan-Horng Lin , Hing L. Sham , Ping Xia

IPC分类号： C07D47102

CPC分类号： C07D401/06 , C07D209/34 , C07D403/06 , C07D471/04

摘要： Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

摘要翻译： 具有其配方的具有治疗上可接受的盐的化合物是蛋白激酶抑制剂。公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。