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    Compositions and methods for the treatment and diagnosis of immune disorders
    41.
    发明授权
    Compositions and methods for the treatment and diagnosis of immune disorders 失效
    用于治疗和诊断免疫疾病的组合物和方法

    公开(公告)号：US06204371B1

    公开(公告)日：2001-03-20

    申请号：US08609583

    申请日：1996-03-01

    申请人： Douglas Adam Levinson

    发明人： Douglas Adam Levinson

    IPC分类号： G12Q166

    CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2227/50 ,  A01K2267/03 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K38/00 ,  B60G13/003 ,  C07K14/70503 ,  C07K16/2803 ,  C07K19/00 ,  C07K2319/00 ,  C12N9/6467 ,  C12N9/6472 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/00 ,  C12Q1/6809 ,  Y02A50/401 ,  Y02A50/57 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

    摘要翻译： 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。 例如，识别在T辅助细胞（TH）细胞和TH细胞亚群内部和之间差异表达的基因，其包括但不限于TH0，TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化，维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面，本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病，特别是TH细胞亚群相关病症治疗的方法。 另外，提供了用于TH细胞亚群相关病症的诊断评估和预后的方法，用于鉴定表现出对这些病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，以及用于监测 化合物用于临床试验。

    T CELL RECEPTORS THAT ARE SPECIFIC TO A FLUORESCENT PROTEIN, TRANSGENIC ANIMALS AND METHODS OF THEIR MAKING, ISOLATED T CELLS, AND METHODS OF USE
    48.
    发明申请
    T CELL RECEPTORS THAT ARE SPECIFIC TO A FLUORESCENT PROTEIN, TRANSGENIC ANIMALS AND METHODS OF THEIR MAKING, ISOLATED T CELLS, AND METHODS OF USE 审中-公开
    特异性荧光蛋白，转基因动物及其制造，分离的T细胞的方法及其使用方法的T细胞受体

    公开(公告)号：US20160219844A1

    公开(公告)日：2016-08-04

    申请号：US15021026

    申请日：2014-09-12

    申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

    发明人： Brian BROWN ,  Judith AGUDO

    IPC分类号： A01K67/027 ,  G01N33/566 ,  C07K14/725

    CPC分类号： A01K67/0275 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/0387 ,  A01K2267/0393 ,  C07K14/7051 ,  C12N15/8509 ,  G01N33/566 ,  G01N2333/70503

    摘要： This invention relates to a transgenic non-human mammal whose genome comprises a polynucleotide sequence encoding a T cell receptor that is specific to a fluorescent protein, where the T cell of the non-human mammal comprises the T cell receptor. The present invention also relates to an isolated T cell from the transgenic non-human mammal of the present invention, an isolated T cell comprising an expression construct comprising a polynucleotide sequence that encodes a T cell receptor that is specific to a fluorescent protein, methods of making transgenic non-human mammals comprising T cell receptors that are specific to a fluorescent protein, a method of depleting cells in a non-human mammal using isolated T cells that encode a T cell receptor that is specific to a target protein, and a method of characterizing a T cell response to an agent.

    摘要翻译： 本发明涉及一种转基因非人哺乳动物，其基因组包含编码对荧光蛋白特异性的T细胞受体的多核苷酸序列，其中非人哺乳动物的T细胞包含T细胞受体。 本发明还涉及本发明的转基因非人哺乳动物的分离的T细胞，包含含有编码对荧光蛋白特异的T细胞受体的多核苷酸序列的表达构建体的分离的T细胞， 制备包含对荧光蛋白特异性的T细胞受体的转基因非人哺乳动物，使用编码靶蛋白特异性的T细胞受体的分离的T细胞消耗非人哺乳动物细胞的方法，以及方法 表征T细胞对药剂的反应。

    Recombinant non-human mammalian model for hepatitis infection and immunopathogenesis
    49.
    发明授权
    Recombinant non-human mammalian model for hepatitis infection and immunopathogenesis 有权
    用于肝炎感染和免疫发病的重组非人哺乳动物模型

    公开(公告)号：US09173383B2

    公开(公告)日：2015-11-03

    申请号：US12918676

    申请日：2009-02-20

    申请人： Lishan Su ,  Liguo Zhang ,  Michael Washburn

    发明人： Lishan Su ,  Liguo Zhang ,  Michael Washburn

    IPC分类号： A01K67/027 ,  C12N9/64 ,  C12N15/85

    CPC分类号： A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/0337 ,  C12N9/6475 ,  C12N15/02 ,  C12N15/8509 ,  G01N33/5088

    摘要： Provided herein is a recombinant non-human mammal having an immune system including human immune cells and having a liver including human liver cells, and methods for producing the same. Also provided are methods of screening a compound for activity in treating hepatitis, comprising: administering a test compound to a recombinant non-human mammal as described herein; and then detecting the presence or absence of said activity in said mammal (e.g., by biochemical assay), said presence of said activity in said mammal indicating that said compound has activity in treating hepatitis. Methods of making fusion cells useful for the production of human monoclonal antibodies are also provided.

    摘要翻译： 本文提供了具有免疫系统的重组非人哺乳动物，其包括人免疫细胞并具有包括人肝细胞的肝脏及其制备方法。 还提供了筛选化合物用于治疗肝炎的活性的方法，其包括：向本文所述的重组非人哺乳动物施用测试化合物; 然后检测所述哺乳动物中所述活性的存在或不存在（例如，通过生化测定），所述哺乳动物中所述活性的存在表明所述化合物具有治疗肝炎的活性。 还提供了制备用于生产人单克隆抗体的融合细胞的方法。