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    Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes
    50.
    发明授权
    Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes 失效
    丙氨酸，其药理学特性及其在特异性抗病毒治疗中的应用，目的

    公开(公告)号：US5143938A

    公开(公告)日：1992-09-01

    申请号：US660873

    申请日：1991-02-26

    申请人： Alain Calvet ,  Agnes Grouhel ,  Henri Jacobelli ,  Jean-Louis Junien ,  Xavier Pascaud

    发明人： Alain Calvet ,  Agnes Grouhel ,  Henri Jacobelli ,  Jean-Louis Junien ,  Xavier Pascaud

    IPC分类号： A61K31/135 ,  A61K31/335 ,  A61K31/357 ,  A61K31/385 ,  C07C205/04 ,  C07C205/09 ,  C07C205/32 ,  C07C205/45 ,  C07C215/30 ,  C07C217/72 ,  C07C225/16 ,  C07C225/18 ,  C07C323/29 ,  C07D317/28 ,  C07D339/06

    CPC分类号： C07C225/16 ,  C07C205/04 ,  C07C205/09 ,  C07C205/32 ,  C07C205/45 ,  C07C217/72 ,  C07D317/28

    摘要： A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur,R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical,or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom,R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical,and W representsa group .dbd.CH--QH,or a heterocycle .dbd.C[Q--(CH2)n--Q],or a group .dbd.C.dbd.Q, in which groupsQ is an oxygen or sulfur atom,n has the value 2 or 3,W being .dbd.C.dbd.Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids.A pharmaceutical composition comprising a compound of general formula (I) with the above definitions for the treatment of diarrheal states.

    摘要翻译： 作为通式（I）的丙胺的化合物，其中：R 1是任选被一个，二或三取代的苯基，或是5或6元单环杂芳基，其中 单个杂原子是氮，氧或硫，R2是低级烷基，R3和R4是氢原子或低级烷基，低级烯基或低级环烷基烷基，或者与它们相连的氮原子一起形成 饱和的5至6元杂环，仅包含一个杂原子，R 5为5-至7-元环烷基，苯基或5-或6-元单环杂芳基，W表示基团= CH-QH， 或杂环= C [Q-（CH 2）nQ]或基团= C = Q，其中基团Q是氧或硫原子，n具有值2或3，W仅当R 3为 和R4不同时为氢，并且它们与药学上可接受的酸相加。 一种药物组合物，其包含具有上述定义用于治疗腹泻状态的通式（I）的化合物。