公开(公告)号：US4741619A

公开(公告)日：1988-05-03

申请号：US47037

申请日：1987-05-05

Applicant: Gillian M. K. Humphries ,  Viola T. Kung

Inventor： Gillian M. K. Humphries ,  Viola T. Kung

IPC: B01L3/00 ,  B29C59/14 ,  G01N21/03

CPC classification number: B01L3/5085 ,  B29C59/14 ,  G01N21/03 ,  G01N2201/0446

Abstract: A microtiter plate prepared from a hydrophobic plastic is rendered more hydrophilic by treatment of the surfaces of the wells of the microplate prior to use. The resulting plates are particularly useful in vertical beam photometry.

公开(公告)号：US4710031A

公开(公告)日：1987-12-01

申请号：US761199

申请日：1985-07-31

Applicant: John E. Kelly ,  Don C. Jones ,  Frederick R. Tuck ,  William A. Zimmermann ,  Kenneth R. Clark

Inventor： John E. Kelly ,  Don C. Jones ,  Frederick R. Tuck ,  William A. Zimmermann ,  Kenneth R. Clark

IPC: G01N21/29 ,  G01N21/00

CPC classification number: G01N21/253 ,  G01N21/29 ,  G01N2201/0446 ,  G01N2201/06126

Abstract: A microtiter plate reader is disclosed which allows visual examination of the contents of the wells of a microtiter plate having an array of wells. The microtiter plate reader includes supporting means for supporting the microtiter plate with the wells opening generally upwardly and a light emitting surface is adapted to extend under a microtiter plate so held. Regions of reduced light emission on the light emitting surface are arranged in an array corresponding in relative position to a selected portion of the array of microtiter plate wells. Locator means are provided for locating the microtiter plate with respect to the array of regions of reduced light emission to allow selective alignment of the wells with the dark regions, providing a dark background to the bottom of the wells which are then illuminated indirectly. The wells can be illuminated directly when the dark regions are out of alignment with the wells.

Abstract translation: 公开了一种微量滴定板读数器，其允许目视检查具有孔阵列的微量滴定板的孔的内容物。 微量滴定板读取器包括用于支撑微量滴定板的支撑装置，其中孔通常向上开口，并且发光表面适于在如此保持的微量滴定板下方延伸。 在发光表面上减少发光的区域以对应于微量滴定板孔阵列的选定部分的相对位置的阵列排列。 提供了定位装置，用于相对于减少发光的区域阵列来定位微量滴定板，以允许孔与暗区域的选择性对准，从而为井的底部间接提供了深色背景。 当暗区与井不对齐时，井可以直接照明。

公开(公告)号：US4501970A

公开(公告)日：1985-02-26

申请号：US433825

申请日：1982-10-12

Applicant: Keith E. Nelson

Inventor： Keith E. Nelson

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6476 ,  G01N2201/0446

Abstract: A sensitive frontal approach fluorometer which is suitable for measuring the fluorescence of samples in open top microtest wells and which has an optical system for (a) directing an exciting light downwardly into the well's open top to fluorescently excite the sample and (b) detecting the sample's emitted light which passes upwardly through the well's open top.

Abstract translation: 一种灵敏的正面进场荧光计，适合于测量开顶微测井中样品的荧光，并且具有光学系统，用于（a）将激发光向下引导到井的开口顶部以荧光激发样品，以及（b）检测 样品发出的光向上通过井的开放顶部。

公开(公告)号：US4498782A

公开(公告)日：1985-02-12

申请号：US268167

申请日：1981-05-29

Applicant: David R. Proctor ,  Terry L. Foster

Inventor： David R. Proctor ,  Terry L. Foster

IPC: G01N21/25 ,  G01N21/27

CPC classification number: G01N21/253 ,  G01N21/251 ,  G01N2201/0446 ,  G01N2201/08

Abstract: The disclosure is of an assembly for determining light transmissiveness of a fluid. The assembly comprises a light source, means of holding the fluid in a light-shielded path of the light generated and a means for receiving and measuring the attenuated light passed through the fluid sample. The assembly is simple and highly portable. As such it is convenient for use with little training in places such as a physician's office, for measuring substances in immunoassay reaction mixtures.

Abstract translation: 本公开是用于确定流体的透光性的组件。 该组件包括一个光源，用于将流体保持在所产生的光的光屏蔽路径中，以及用于接收和测量通过流体样品的衰减光的装置。 组装简单，高度便携。 因此，在诸如医生办公室等用于测量免疫测定反应混合物中的物质方面的使用方便。

公开(公告)号：US4310763A

公开(公告)日：1982-01-12

申请号：US84662

申请日：1979-10-15

Applicant: John Shields

Inventor： John Shields

IPC: G01N21/05 ,  G01J1/24 ,  G01N1/10 ,  G01N1/36 ,  G01N21/01 ,  G01N21/11 ,  G01N21/25 ,  G01N21/35 ,  G01N21/49 ,  G01N33/04 ,  G01N21/26

CPC classification number: G01N21/251 ,  G01N33/04 ,  G01J1/24 ,  G01N2201/0446 ,  G01N2201/127 ,  Y10S250/91

Abstract: Electro-optical apparatus for measurement of fat, protein, lactose and water or solids in milk wherein a milk sample is pumped by a homogenizer into an optical measurement cell. The specimen in the cell is then irradiated with reference and measurement beams at differing wavelengths for fat, protein, lactose and water respectively, and signals are stored indicative of uncorrected concentrations. A scaling and correction circuit includes cross-correction circuitry for compensating the effects on each reading caused by the other constituents. The signals so corrected are then provided in percentage by weight or weight over volume on suitable digital displays.

Abstract translation: 用于测量乳中脂肪，蛋白质，乳糖和水或固体的电光装置，其中将牛奶样品通过均化器泵送到光学测量单元中。 然后分别用脂肪，蛋白质，乳糖和水分别以不同波长的参考和测量光束照射细胞中的样品，并且存储指示未校正浓度的信号。 缩放和校正电路包括用于补偿由其他成分引起的对每次读取的影响的交叉校正电路。 然后如此校正的信号以合适的数字显示器上的体积重量或重量的百分比提供。

公开(公告)号：US11860108B2

公开(公告)日：2024-01-02

申请号：US17961219

申请日：2022-10-06

Applicant: Optofluidic Bioassay, LLC

Inventor： Maung Kyaw Khaing Oo ,  Xudong Fan

IPC: G01N21/77 ,  B01L3/00 ,  G01N21/78 ,  G01N21/76 ,  G01N21/75

CPC classification number: G01N21/77 ,  B01L3/5085 ,  G01N21/78 ,  B01L2300/0663 ,  B01L2300/0809 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/168 ,  G01N21/76 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/0446

Abstract: An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens.

公开(公告)号：US20180252701A1

公开(公告)日：2018-09-06

申请号：US15907695

申请日：2018-02-28

Applicant: Specific Technologies, LLC

Inventor： Paul A. Rhodes ,  Soumitesh Chakravorty ,  Sung Hyun Lim

IPC: G01N33/50 ,  G01N21/03 ,  C12Q1/02 ,  C12Q3/00

CPC classification number: G01N33/5008 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q3/00 ,  G01N21/03 ,  G01N21/78 ,  G01N21/80 ,  G01N2021/0118 ,  G01N2201/0446

Abstract: Devices, systems, and methods for strain-specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism. An exemplary method includes culturing a sample containing microorganisms in a medium and in gaseous communication with a colorimetric sensor array. Sensors in the colorimetric sensor array are exposed to volatile organic compounds produced by the microorganism. The method then includes assessing a resistance of the microorganism to at least one substance. The resistance is assessed based on a response of the sensors in the colorimetric sensor array to the volatile organic compounds produced by the microorganism.

公开(公告)号：US20180231465A1

公开(公告)日：2018-08-16

申请号：US15882776

申请日：2018-01-29

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Paul E. Glenn ,  Lawrence C. West ,  Benjamin Cipriany ,  Keith G. Fife

IPC: G01N21/64 ,  C12Q1/6874

CPC classification number: G01N21/6408 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/0446 ,  G01N2201/062

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

公开(公告)号：US20180171387A1

公开(公告)日：2018-06-21

申请号：US15717103

申请日：2017-09-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C12Q1/686 ,  G01N21/27 ,  G01N21/64 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

公开(公告)号：US09784685B2

公开(公告)日：2017-10-10

申请号：US14566708

申请日：2014-12-10

Applicant: Molecular Devices, LLC

Inventor： Josef J. Atzler ,  Michael Katzlinger ,  Georg Kronberger ,  Bernhard Schinwald

IPC: G01N35/02 ,  G01N21/64 ,  G01N35/10 ,  G01J3/02 ,  G01N21/76 ,  G01J3/00 ,  G01N21/25

CPC classification number: G01N21/76 ,  G01J3/02 ,  G01N21/15 ,  G01N21/253 ,  G01N21/763 ,  G01N27/223 ,  G01N35/028 ,  G01N2021/015 ,  G01N2021/155 ,  G01N2035/1025 ,  G01N2201/0225 ,  G01N2201/0245 ,  G01N2201/0446 ,  G01N2201/0806

Abstract: In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.