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    Transfection reagents
    45.
    发明申请
    Transfection reagents 有权

    公开(公告)号：US20050164391A1

    公开(公告)日：2005-07-28

    申请号：US11040687

    申请日：2005-01-21

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C215/18 ,  C07C217/08 ,  C07C229/26 ,  C07C237/10 ,  C07C279/08 ,  C07D211/26 ,  C07D213/38 ,  C07D241/12 ,  C07D273/08 ,  C07D291/02 ,  C12N5/10 ,  C12N15/85 ,  C07C275/14 ,  C07D241/02 ,  C07K14/47

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Transfection reagents
    47.
    发明申请
    Transfection reagents 有权

    公开(公告)号：US20050124069A1

    公开(公告)日：2005-06-09

    申请号：US11040562

    申请日：2005-01-21

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C215/18 ,  C07C217/08 ,  C07C229/26 ,  C07C237/10 ,  C07C279/08 ,  C07D211/26 ,  C07D213/38 ,  C07D241/12 ,  C07D273/08 ,  C07D291/02 ,  C12N5/10 ,  C12N15/88 ,  C07D43/02

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Preparation of amines from olefins over zeolites of the type PSH-3, MCM-22, SSZ-25 or mixtures thereof
    48.
    发明授权
    Preparation of amines from olefins over zeolites of the type PSH-3, MCM-22, SSZ-25 or mixtures thereof 失效
    由PSH-3，MCM-22，SSZ-25类型的沸石或其混合物的烯烃制备胺

    公开(公告)号：US5900508A

    公开(公告)日：1999-05-04

    申请号：US683227

    申请日：1996-07-18

    申请人： Karsten Eller ,  Ulrich Muller ,  Rudolf Kummer ,  Peter Stops

    发明人： Karsten Eller ,  Ulrich Muller ,  Rudolf Kummer ,  Peter Stops

    IPC分类号： B01J29/70 ,  B01J29/74 ,  B01J29/76 ,  B01J29/78 ,  C07B61/00 ,  C07C209/60 ,  C07C211/03 ,  C07C211/17 ,  C07C211/21 ,  C07C211/23 ,  C07C211/27 ,  C07C211/35 ,  C07C211/45

    CPC分类号： C07C209/60 ,  Y02P20/582

    摘要： A process for the preparation of amines by reacting an olefin with ammonia or a primary or secondary amine at a temperature of from 200 to 350.degree. C. and a pressure of from 100 to 300 bar in the presence of at least one zeolite having the specific structure type PSH-3, MCM-22 or SSZ-25, as identified by X-ray diffractogram, or mixtures of these zeolites. These specific catalysts are broadly identified as alumina zeolites and may be modified by ion exchange, doping with other metals, by dealumination to remove or replace the alumina content and by other well known after treatments such as calcination, acid-treatment and the like. Monoolefins are preferred reactants but di- and polyolefins also can be reacted with relatively high selectivity and less tendency toward polymerization.

    摘要翻译： 一种通过使烯烃与氨或伯胺或仲胺在200-350℃的温度和100-300巴的压力下在至少一种具有特定的沸点的沸石存在下反应来制备胺的方法 结构型PSH-3，MCM-22或SSZ-25，通过X射线衍射图鉴定，或这些沸石的混合物。 这些特定的催化剂被广泛地认定为氧化铝沸石，并且可以通过离子交换，掺杂其它金属，通过脱铝来除去或替代氧化铝含量，以及通过煅烧，酸处理等处理之后熟知的其它催化剂进行改性。 单烯烃是优选的反应物，但是二烯烃和聚烯烃也可以以相对高的选择性和较少的聚合倾向反应。

    Preparation of amines from olefins over zeolites of the type SSZ-37
    49.
    发明授权
    Preparation of amines from olefins over zeolites of the type SSZ-37 失效
    通过SSZ-37型沸石从烯烃制备胺

    公开(公告)号：US5739405A

    公开(公告)日：1998-04-14

    申请号：US760296

    申请日：1996-12-04

    申请人： Karsten Eller ,  Rudolf Kummer ,  Peter Stops

    发明人： Karsten Eller ,  Rudolf Kummer ,  Peter Stops

    IPC分类号： B01J29/06 ,  C07B61/00 ,  C07C209/60 ,  C07C211/03 ,  C07C211/07 ,  C07C211/17 ,  C07C211/21 ,  C07C211/25 ,  C07C211/26 ,  C07C211/35 ,  C07C211/40 ,  C07C211/45

    CPC分类号： C07C209/60 ,  Y02P20/582

    摘要： A process for the preparation of amines of the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 denote hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 cycloalkyl, C.sub.4 -C.sub.20 alkylcycloalkyl, C.sub.4 -C.sub.20 cycloalkylalkyl, aryl, C.sub.7 -C.sub.20 alkylaryl, or C.sub.7 -C.sub.20 aralkyl, R.sup.1 and R.sup.2 together denote a saturated or unsaturated C.sub.3 -C.sub.9 alkylene dichain and R.sup.3 or R.sup.5 denotes C.sub.21 -C.sub.200 alkyl, C.sub.21 -C.sub.200 alkenyl or they together form a C.sub.2 -C.sub.12 alkylene dichain, by the reaction of olefins of the general formula II ##STR2## in which R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have the above meanings, with ammonia or primary or secondary amines of the general formula III ##STR3## in which R.sup.1 and R.sup.2 have the above meanings, at temperatures ranging from 200.degree. to 350.degree. C. and pressures ranging from 100 to 300 bar in the presence of a heterogeneous catalyst, wherein the heterogeneous catalyst used is a zeolite of the type SSZ-37.

    摘要翻译： 制备通式I（I）的胺的方法，其中R 1，R 2，R 3，R 4，R 5，R 6表示氢，C 1 -C 20烷基，C 2 -C 20烯基，C 2 -C 20炔基，C 3 -C 20环烷基，C 4 -C 20烷基环烷基，C 4 -C 20环烷基烷基，芳基，C 7 -C 20烷基芳基或C 7 -C 20芳烷基，R 1和R 2一起表示饱和或不饱和的C 3 -C 9亚烷基二
    烯基，R 3或R 5表示C 21 -C 200烷基 C21 -C200烯基或它们一起形成C 2 -C 12亚烷基二酮，通过其中R3，R4，R5和R6具有上述含义的通式II（II）的烯烃与氨或 在其中R1和R2具有上述含义的通式III（III）的伯或仲胺中，在200-350℃的温度和100-300巴的压力范围内，在异质的存在下 催化剂，其中所用的非均相催化剂是SSZ-37型沸石。

    Iridium complexes, process for their preparation and their use
    50.
    发明授权
    Iridium complexes, process for their preparation and their use 失效
    IRIDIUM复合物，其制备方法及其使用

    公开(公告)号：US5112999A

    公开(公告)日：1992-05-12

    申请号：US580711

    申请日：1990-09-11

    申请人： John A. Osborn ,  You P. N. C. Chan ,  Hans-Ulrich Blaser ,  Felix Spindler

    发明人： John A. Osborn ,  You P. N. C. Chan ,  Hans-Ulrich Blaser ,  Felix Spindler

    IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C209/44 ,  C07C209/52 ,  C07C211/03 ,  C07C211/21 ,  C07C213/02 ,  C07C217/08 ,  C07C231/16 ,  C07F15/00

    CPC分类号： C07F15/004

    摘要： Compounds of general formula I or Ia ##STR1## or mixtures thereof, wherein the groups P-L-P are a ligand from the group comprising diphosphine and diphosphinite, in which the secondary phosphine groups or phosphinite groups P are coupled via 2 to 4 C atoms, and which form a 5-, 6- or 7-membered ring with the Ir atoms, X, X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5 and X.sup.6 independently of the others are Cl, Br or I, or X.sup.1 and X.sup.6 and H and X.sup.2, X.sup.3, X.sup.4 and X.sup.5 independently of the others are Cl, Br or I, or X.sup.1 and X.sup.5 and H and X.sup.2, X.sup.3, X.sup.4 and X.sup.6 independently of the others are Cl, Br or I, and M.sup..sym. is an alkali metal cation or quaternary ammonium. The compounds are suitable as homogeneous catalysts for the (preferably) asymmetric hydrogenation of N-substituted imines to secondary amines.

    摘要翻译： （Ⅰ）或其混合物的通式I或Ia化合物或其混合物，其中基团PLP是来自包括二膦和二磷酸盐的基团的配体，其中仲膦基团或次膦酸基团P连接 通过2至4个C原子，并且与Ir原子形成5-，6-或7-元环，其中X，X 1，X 2，X 3，X 4，X 5和X 6独立地为Cl，Br或I， 或者X 1和X 6以及H和独立地为Cl，Br或I的X 1，X 3，X 4和X 5分别为Cl，Br或I，或者X 1和X 5以及H和独立地为Cl，Br或I的X 2，X 3，X 4和X 6， M（+）是碱金属阳离子或季铵。 该化合物适合用作（优选）N-取代亚胺对仲胺的不对称氢化的均相催化剂。