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公开(公告)号：US20220324897A1
公开(公告)日：2022-10-13
申请号：US17596900
申请日：2020-07-03
发明人： Qinghua MAO , Tao YU , Yi LI , Chengde WU , Ting YAO
摘要： Crystal form A of a compound represented by formula (I) and an application thereof in preparing a drug for treating an SGLT1/SGLT2-related disease.
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公开(公告)号：USRE49080E1
公开(公告)日：2022-05-24
申请号：US16793734
申请日：2020-02-18
申请人： Novartis AG
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
IPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
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公开(公告)号：US11084842B2
公开(公告)日：2021-08-10
申请号：US16960488
申请日：2019-01-22
发明人： Zheng Gu , Wuyong Wu , Tong Qu , Panpan Kang , Zongyuan Zhang , Weiming Huang , Jianyu Liu , Yingjun Zhang
IPC分类号： C07H7/04 , C07H15/207
摘要： A glucopyranosyl derivative as a sodium-dependent glucose transporters inhibitor, especially as a SGLT1 inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, a pharmaceutical composition thereof, and the uses of the compound and pharmaceutical composition thereof in the preparation of drugs for the treatment of diabetes and diabetes-related diseases.
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公开(公告)号：US11072625B2
公开(公告)日：2021-07-27
申请号：US16339646
申请日：2017-10-06
申请人： GLYCOMIMETICS, INC.
发明人： John L. Magnani , John M. Peterson , Myung-Gi Baek
摘要： Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, highly potent multimeric E-selectin antagonist are desorbed and pharmaceutical compositions comprising at least one of the same.
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45.发明申请公开(公告)号：US20210205324A1
公开(公告)日：2021-07-08
申请号：US17073827
申请日：2020-10-19
IPC分类号： A61K31/5513 , A61K31/4515 , A61K31/551 , A61K31/7034 , A61K31/7048 , A61K45/06 , C07H7/04 , A61K31/351 , A61K31/381
摘要： The invention relates to methods for preventing, slowing the progression of, delaying or treating metabolic disorders induced in patients by the treatment with neuroleptic agents comprising administering to the patients an SGLT2 inhibitor.
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公开(公告)号：US10570112B2
公开(公告)日：2020-02-25
申请号：US16045047
申请日：2018-07-25
申请人： FUJIFILM Corporation
发明人： Kouki Nakamura , Satoshi Shimamura , Junichi Imoto , Motomasa Takahashi , Katsuyuki Watanabe , Kenji Wada , Yuuta Fujino , Takuya Matsumoto , Makoto Takahashi , Hideki Okada , Takehiro Yamane , Takayuki Ito
IPC分类号： C07C47/277 , C07D333/32 , C07F7/18 , C07C67/29 , C07C68/06 , C07C69/28 , C07C69/618 , C07C69/76 , C07C69/92 , C07C69/96 , A61K31/7068 , C07C303/28 , C07C45/00 , C07B53/00 , C07C309/73 , C07C249/04 , C07C251/38 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H15/203 , C07H17/02 , C07H19/067 , C07H19/073 , C07H23/00 , C07H19/06 , C07C69/78 , C07H1/00 , C07H7/04 , C07C251/40 , C07C309/66
摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.
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47.发明授权公开(公告)号：US10519183B2
公开(公告)日：2019-12-31
申请号：US16096119
申请日：2017-03-27
摘要： Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.
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公开(公告)号：US20180327377A1
公开(公告)日：2018-11-15
申请号：US16045047
申请日：2018-07-25
申请人： FUJIFILM Corporation
发明人： Kouki NAKAMURA , Satoshi SHIMAMURA , Junichi IMOTO , Motomasa TAKAHASHI , Katsuyuki WATANABE , Kenji WADA , Yuuta FUJINO , Takuya MATSUMOTO , Makoto TAKAHASHI , Hideki OKADA , Takehiro YAMANE , Takayuki ITO
IPC分类号： C07D333/32 , C07F7/18 , A61K31/7068 , C07C47/277 , C07C251/40 , C07C309/66 , C07H19/06 , C07H7/04 , C07H1/00 , C07C303/28 , C07C45/00 , C07B53/00 , C07C309/73 , C07C249/04 , C07C251/38 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H15/203 , C07H17/02 , C07H19/067 , C07H19/073 , C07H23/00 , C07C69/96 , C07C69/92 , C07C69/76 , C07C69/618 , C07C69/28 , C07C68/06 , C07C67/29 , C07C69/78
摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.
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公开(公告)号：US20180282363A1
公开(公告)日：2018-10-04
申请号：US16000079
申请日：2018-06-05
发明人： Sumihiro NOMURA , Eiji KAWANISHI , Kiichiro UETA
IPC分类号： C07H19/056 , C07H19/048 , C07H19/044 , C07H19/04 , C07H7/06 , A61K31/7056 , A61K38/24 , A61K38/28 , A61K45/06 , A61K31/7042 , C07H7/04
摘要： A compound of the formula: wherein Ring A and Ring B are: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring or an optionally substituted unsaturated fused heterobicyclic ring, or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, and Ring B are independently an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; X is a carbon atom or a nitrogen atom; Y is —(CH2)n— (n is 1 or 2); or a pharmaceutically acceptable salt thereof, or a prodrug thereof.
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公开(公告)号：US09963478B2
公开(公告)日：2018-05-08
申请号：US15140045
申请日：2016-04-27
发明人： Yeeman K. Ramtohul , Sanjoy Kumar Das , Caroline Cadilhac , Thumkunta Jagadeeswar Reddy , Louis Vaillancourt , Michel Gallant , Bingcan Liu , Evelyne Dietrich , Frederic Vallee , Julien Martel , Carl Poisson
IPC分类号： A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K31/706 , A61K31/7064 , C07H7/02 , C07D405/14 , C07D309/10 , C07H15/26 , C07D409/14 , C07H19/056 , C07D417/14 , C07H7/04 , C07H7/06 , C07H19/02 , C07D413/14 , C07D407/14 , C07D495/04
CPC分类号： C07H7/02 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K31/706 , A61K31/7064 , C07D309/10 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04 , C07H7/04 , C07H7/06 , C07H15/26 , C07H19/02 , C07H19/056
摘要： The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.
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