公开(公告)号：US10570112B2

公开(公告)日：2020-02-25

申请号：US16045047

申请日：2018-07-25

Applicant: FUJIFILM Corporation

Inventor： Kouki Nakamura ,  Satoshi Shimamura ,  Junichi Imoto ,  Motomasa Takahashi ,  Katsuyuki Watanabe ,  Kenji Wada ,  Yuuta Fujino ,  Takuya Matsumoto ,  Makoto Takahashi ,  Hideki Okada ,  Takehiro Yamane ,  Takayuki Ito

IPC: C07C47/277 ,  C07D333/32 ,  C07F7/18 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/92 ,  C07C69/96 ,  A61K31/7068 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07H19/06 ,  C07C69/78 ,  C07H1/00 ,  C07H7/04 ,  C07C251/40 ,  C07C309/66

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US09187514B2

公开(公告)日：2015-11-17

申请号：US14621119

申请日：2015-02-12

Applicant: FUJIFILM Corporation

Inventor： Kouki Nakamura ,  Satoshi Shimamura ,  Junichi Imoto ,  Motomasa Takahashi ,  Katsuyuki Watanabe ,  Kenji Wada ,  Yuuta Fujino ,  Takuya Matsumoto ,  Makoto Takahashi ,  Hideki Okada ,  Takehiro Yamane ,  Takayuki Ito

IPC: C07D409/04 ,  C07H19/06 ,  A61K31/7068 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07C69/78 ,  C07H1/00 ,  C07H7/04 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/92 ,  C07C69/96

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US11492252B2

公开(公告)日：2022-11-08

申请号：US16583260

申请日：2019-09-26

Applicant: FUJIFILM Corporation

Inventor： Hideki Matsumoto ,  Kenji Wada

IPC: C09K11/62 ,  B82B3/00 ,  C01B25/08 ,  G01N33/58 ,  H01L21/02 ,  H01L29/06 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A method for producing a Group III-V semiconductor nanoparticle by flow reaction, including: introducing a solution of compound containing Group III element into a first flow channel, introducing a solution of compound containing Group V element into a second flow channel, and combining the solutions to produce nanoparticles, in which the combining portion is constituted by a multi-layered tubular mixer, one of the solutions is allowed to flow through a flow channel in the smallest tube of the mixer, and the other of the solutions is allowed to flow through a flow channel adjacent to the flow channel in the smallest tube, and a value of a ratio of linear velocity of the solution flowing in the flow channel adjacent to the flow channel in the smallest tube to linear velocity of the solution flowing in the flow channel in the smallest tube is a specific value.

公开(公告)号：US11332551B2

公开(公告)日：2022-05-17

申请号：US16826288

申请日：2020-03-22

Applicant: FUJIFILM Corporation

Inventor： Kenji Wada ,  Hideki Matsumoto ,  Kei Harada

IPC: C08F2/01 ,  C08F2/06 ,  C08F2/38 ,  C08F4/48 ,  C08F2/04 ,  C08F2/40 ,  C08F12/08 ,  C08K5/56 ,  B01J8/06

Abstract: A method for manufacturing a polymer by performing an anionic polymerization reaction by a flow-type reaction, including: introducing a liquid A containing an anionic polymerizable monomer, a liquid B containing an anionic polymerization initiator, and a polymerization terminator into different flow paths respectively and causing the liquids to flow in the respective flow paths; causing the liquid A and the liquid B to join together by using a multilayered cylindrical mixer; subjecting the anionic polymerizable monomer to anionic polymerization while a solution formed by the joining is flowing to downstream in the reaction flow path; and causing a polymerization reaction solution flowing in a reaction flow path and the polymerization terminator to join together such that the polymerization reaction is terminated; and a flow-type reaction system suitable for performing the manufacturing method.

公开(公告)号：US10947112B2

公开(公告)日：2021-03-16

申请号：US16137504

申请日：2018-09-20

Applicant: FUJIFILM Corporation

Inventor： Kenji Wada ,  Yuji Yoshida

IPC: B82Y20/00 ,  B82Y40/00 ,  C09K11/70 ,  B82Y30/00 ,  C09K11/66 ,  C09K11/74 ,  C09K11/08 ,  C09K11/62 ,  C09K11/88 ,  B82Y15/00

Abstract: There is provided a method of manufacturing a semiconductor quantum dot including the following steps (A1) and (B1): a step (A1) of causing a nanoparticle including a specific compound semiconductor and a salt of a specific metal a1 to react with each other to introduce the metal a1 into a surface layer of the nanoparticle; and a step (B1) of causing the nanoparticle in which the metal a1 is introduced into the surface layer and a salt of a specific metal b1 to react with each other to introduce the metal b1 into the surface layer of the nanoparticle. There is provided a semiconductor quantum dot having a structure in which a specific metal a1 and/or a specific metal b1 is introduced into a surface layer of a nanoparticle including a specific compound semiconductor.

公开(公告)号：US09221865B2

公开(公告)日：2015-12-29

申请号：US14621119

申请日：2015-02-12

Applicant: FUJIFILM Corporation

Inventor： Kouki Nakamura ,  Satoshi Shimamura ,  Junichi Imoto ,  Motomasa Takahashi ,  Katsuyuki Watanabe ,  Kenji Wada ,  Yuuta Fujino ,  Takuya Matsumoto ,  Makoto Takahashi ,  Hideki Okada ,  Takehiro Yamane ,  Takayuki Ito

IPC: C07D409/04 ,  C07H19/06 ,  A61K31/7068 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07C69/78 ,  C07H1/00 ,  C07H7/04 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/92 ,  C07C69/96

CPC classification number: C07D333/32 ,  A61K31/7068 ,  C07B53/00 ,  C07C45/00 ,  C07C47/277 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C69/96 ,  C07C249/04 ,  C07C251/38 ,  C07C251/40 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07F7/1804 ,  C07H1/00 ,  C07H7/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  Y02P20/55

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

Abstract translation: 由下式（其中R1A，R1B，R2A，R2B，R3A和R3B表示氢原子，任选取代的C 1-6烷基等）表示的由式[1D]表示的化合物可用作生产中间体 硫代核苷，本发明的制造方法可用作硫代核苷的制造方法。

公开(公告)号：US11242414B2

公开(公告)日：2022-02-08

申请号：US16992079

申请日：2020-08-12

Applicant: FUJIFILM Corporation

Inventor： Kenji Wada ,  Kei Harada

IPC: C08F2/01 ,  B01J19/24 ,  C08F2/14 ,  C08F2/38 ,  C08K5/56

Abstract: The present invention provides a method for manufacturing a polymer by a flow-type reaction. The method includes introducing a liquid A of an anionic polymerizable monomer, a liquid B of an anionic polymerization initiator, and a polymerization terminator into different flow paths, allowing the liquids to flow in the flow paths, allowing the liquid A and the liquid B to join together, subjecting the monomer to anionic polymerization while the liquids having joined together are flowing to downstream in a reaction flow path, and allowing a solution, which is obtained by the polymerization reaction and flows in the reaction flow path, and the polymerization terminator to join together so as to terminate the polymerization reaction and to obtain a polymer having a number-average molecular weight of 5,000 to 200,000. A static mixer is disposed in the reaction flow path, and a polymer having a number-average molecular weight equal to or greater than 2,000 is introduced into an inlet port of the mixer. The present invention also provides a flow-type reaction system suitable for performing the manufacturing method.

公开(公告)号：US10093645B2

公开(公告)日：2018-10-09

申请号：US15246177

申请日：2016-08-24

Applicant: FUJIFILM Corporation

Inventor： Kouki Nakamura ,  Satoshi Shimamura ,  Junichi Imoto ,  Motomasa Takahashi ,  Katsuyuki Watanabe ,  Kenji Wada ,  Yuuta Fujino ,  Takuya Matsumoto ,  Makoto Takahashi ,  Hideki Okada ,  Takehiro Yamane ,  Takayuki Ito

IPC: C07C47/277 ,  C07D333/32 ,  A61K31/7068 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07H19/06 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07C69/78 ,  C07H1/00 ,  C07H7/04 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/92 ,  C07C69/96 ,  C07C251/40 ,  C07C309/66 ,  C07F7/18

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US09475835B2

公开(公告)日：2016-10-25

申请号：US14873966

申请日：2015-10-02

Applicant: FUJIFILM Corporation

Inventor： Kouki Nakamura ,  Satoshi Shimamura ,  Junichi Imoto ,  Motomasa Takahashi ,  Katsuyuki Watanabe ,  Kenji Wada ,  Yuuta Fujino ,  Takuya Matsumoto ,  Makoto Takahashi ,  Hideki Okada ,  Takehiro Yamane ,  Takayuki Ito

IPC: C07D333/26 ,  C07D333/28 ,  C07D333/32 ,  C07H19/06 ,  A61K31/7068 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07C69/78 ,  C07H1/00 ,  C07H7/04 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/92 ,  C07C69/96

CPC classification number: C07D333/32 ,  A61K31/7068 ,  C07B53/00 ,  C07C45/00 ,  C07C47/277 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C69/96 ,  C07C249/04 ,  C07C251/38 ,  C07C251/40 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07F7/1804 ,  C07H1/00 ,  C07H7/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  Y02P20/55

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US12024573B2

公开(公告)日：2024-07-02

申请号：US17210514

申请日：2021-03-24

Applicant: FUJIFILM Corporation

Inventor： Kenji Wada ,  Hideki Matsumoto ,  Kei Harada

IPC: C08F2/01 ,  B01J19/18 ,  C08F2/06 ,  C08F2/38 ,  C08F2/42 ,  C08F12/08 ,  C08K5/56 ,  C08F12/06

CPC classification number: C08F2/06 ,  B01J19/1812 ,  C08F2/01 ,  C08F2/38 ,  C08F2/42 ,  C08K5/56 ,  C08F12/06 ,  C08F12/08

Abstract: Provided is a method for manufacturing a polymer by a flow-type reaction, including introducing a liquid A containing an anionic polymerizable monomer and a non-polar solvent, a liquid B containing an anionic polymerization initiator and a non-polar solvent, a liquid C containing a polar solvent, and a polymerization terminator into different flow paths; allowing the liquids to flow in the respective flow paths; allowing the liquid A and the liquid B to join together at a joining portion; allowing a conjoined liquid MAB of the liquid A and the liquid B to join with the liquid C at downstream of the joining portion; subjecting the anionic polymerizable monomer to anionic polymerization while a conjoined liquid MABC of the conjoined liquid MAB and the liquid C is flowing to downstream in a reaction flow path; and allowing a polymerization reaction solution flowing in the reaction flow path to join with the polymerization terminator so that the polymerization reaction is terminated and a polymer is obtained, in which a polarity of a solvent of the liquid MABC is made higher than a polarity of a solvent of the liquid MAB. Also provided is a flow-type reaction system suited for performing the manufacturing method.