公开(公告)号：US20160354410A1

公开(公告)日：2016-12-08

申请号：US15242666

申请日：2016-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Assaf LASK ,  Eran OPHIR ,  Noga OR-GEVA ,  Adva COHEN ,  Ran AFIK ,  Esther BACHAR-LUSTIG ,  Yaki EIDELSTEIN

IPC: A61K35/17 ,  A61K35/28 ,  C12N5/0783 ,  A61K45/06

CPC classification number: A61K35/17 ,  A61K31/517 ,  A61K35/28 ,  A61K39/001 ,  A61K45/06 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0602 ,  C12N5/0636 ,  C12N5/0637 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  A61K2300/00

Abstract: A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.

公开(公告)号：US20160326250A1

公开(公告)日：2016-11-10

申请号：US15147178

申请日：2016-05-05

Applicant: Yeda Research and Development Co. Ltd. ,  Victor Chang Cardiac Research Institute

Inventor： Eldad TZAHOR ,  Gabriele Matteo D'UVA ,  Rachel SARIG ,  Alla AHARONOV ,  Richard Paul HARVEY ,  Kfir Baruch UMANSKY

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/50 ,  A61K38/18

CPC classification number: C07K16/2863 ,  A61K9/00 ,  A61K31/7115 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/1883 ,  A61K39/3955 ,  C07K2317/75 ,  G01N33/5023 ,  G01N33/5061 ,  A61K2300/00

Abstract: A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof. The method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment.

Abstract translation: 在有需要的受试者中用神经调节蛋白处理增强心脏再生的方法。 该方法包括向受试者施用治疗有效量的上调ErbB-2的活性或表达的试剂，从而通过神经调节蛋白处理增强心脏再生。

公开(公告)号：US20160298103A1

公开(公告)日：2016-10-13

申请号：US15189021

申请日：2016-06-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ron MILO ,  Arren BAR-EVEN ,  Elad NOOR

IPC: C12N9/00 ,  C12P7/46 ,  C12N15/70 ,  C12N9/10 ,  C12N9/88 ,  C12P11/00 ,  C12P7/42

CPC classification number: C12N9/93 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  C12N15/70 ,  C12N15/8245 ,  C12N15/8247 ,  C12N15/8269 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P11/00 ,  C12Y101/01059 ,  C12Y102/01018 ,  C12Y201/03001 ,  C12Y208/03001 ,  C12Y401/01031 ,  C12Y402/01017 ,  C12Y402/01054 ,  C12Y604/01001 ,  C12Y604/01002 ,  G06F19/12 ,  Y02P20/52

Abstract: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Abstract translation: 提供了一种用于碳固定的系统。 该系统包括催化碳固定通道的反应的酶，其中碳固定通路的至少一个反应是羧化反应，其中碳固定路径的反应产物包括草酰乙酸酯和丙二酰辅酶A，其中酶 进行羧化反应的选自苯丙醇丙酮酸（PEP）羧基酶，丙酮酸羧化酶和乙酰​​辅酶A羧化酶，其中碳固定路径的出口产物是乙醛酸盐。 还提供了另外的碳固定路径和产生它们的方法。

公开(公告)号：US09416195B2

公开(公告)日：2016-08-16

申请号：US13872265

申请日：2013-04-29

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit Sagi ,  Tamar Danon ,  Netta Sela ,  Abraham Shanzer ,  Rina Arad-Yellin ,  Raghavendra Kikkeri

IPC: C07K16/44 ,  C07F3/06 ,  C07D233/61 ,  C07K16/40

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

公开(公告)号：US09359607B2

公开(公告)日：2016-06-07

申请号：US14277825

申请日：2014-05-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Hornstein ,  Alon Chen ,  Sharon Haramati ,  Elik Chapnik

IPC: C12N15/113 ,  C12Q1/68 ,  A61P25/02 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/7088

Abstract: Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND).

Abstract translation: 公开了用于制备用于治疗运动神经元疾病（MND）的药物的上调miRNA-9或miRNA-9 *的活性或量的试剂的用途。

公开(公告)号：US09355698B2

公开(公告)日：2016-05-31

申请号：US14385006

申请日：2013-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Ron Naaman ,  Yossef Paltiel ,  Sivan Kober ,  Gilad Gotesman

IPC: G11C11/00 ,  G11C11/16 ,  B82Y10/00 ,  G11C11/56 ,  G11C13/00 ,  H01L43/10 ,  H03K19/00 ,  H01L51/00 ,  H01L51/05 ,  H01L29/06 ,  H01L27/28

CPC classification number: G11C11/16 ,  B82Y10/00 ,  G11C11/161 ,  G11C11/5607 ,  G11C13/0014 ,  G11C13/0016 ,  G11C13/0019 ,  H01L27/285 ,  H01L29/0665 ,  H01L43/10 ,  H01L51/0093 ,  H01L51/0595 ,  H03K19/0008

Abstract: In accordance with one exemplary embodiment of the present technique, there is disclosed a spins selective device, including a first layer comprising a ferromagnetic material. The spin selective device further includes a second layer coupled to the first layer. The second layer includes at least one molecule having a specified chirality, such that when an electrical current flows between the first layer and the second layer one or more regions of the ferromagnetic material become magnetically polarized along a certain direction.

Abstract translation: 根据本技术的一个示例性实施例，公开了一种自旋选择装置，包括包含铁磁材料的第一层。 自旋选择装置还包括耦合到第一层的第二层。 第二层包括具有指定手性的至少一个分子，使得当电流在第一层和第二层之间流动时，铁磁材料的一个或多个区域沿着某一方向变得磁极化。

公开(公告)号：US09346854B2

公开(公告)日：2016-05-24

申请号：US14323408

申请日：2014-07-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yechiel Shai ,  Avner Fink ,  Shay Yaari ,  Tova Waks ,  Zelig Eshhar ,  Christopher J. Arnush

IPC: C07K7/00 ,  C07K7/08 ,  A61K38/08 ,  C07K14/00

CPC classification number: C07K7/08 ,  A61K38/08 ,  C07K7/00 ,  C07K14/001

Abstract: Isolated peptides of 13-30 amino acids comprising 5-9 consecutive repeats of the amino acid pair Alanine-Leucine or Alanine-Valine are provided. The peptides further comprise a stretch of 1-3 Lysine residues present at least at one of the peptide's termini, wherein the only Lysine residue in the isolated peptide is present at the stretch of 1-3 Lysine residues. Pharmaceutical compositions comprising same, methods of treating inflammatory conditions and allergic reactions, as well as methods of neutralizing the activity of lypopolysaccharides are also provided.

Abstract translation: 提供了包含氨基酸对丙氨酸 - 亮氨酸或丙氨酸 - 缬氨酸的5-9个连续重复的13-30个氨基酸的分离的肽。 所述肽还包含存在于至少一个肽末端的1-3个赖氨酸残基，其中分离的肽中唯一的赖氨酸残基以1-3个赖氨酸残基的一段存在。 还提供了包含其的药物组合物，治疗炎性病症和过敏反应的方法，以及中和赖福多糖活性的方法。

公开(公告)号：US20160122765A1

公开(公告)日：2016-05-05

申请号：US14849013

申请日：2015-09-09

Applicant: Arizona Board of Regents, a Body Corporate of the State of Arizona Acting for and on Behalf of Arizo ,  Yeda Research and Development Co. Ltd.

Inventor： Douglas LAKE ,  Benjamin Katchman ,  Deborah Fass

IPC: C12N15/113

CPC classification number: A61K39/3955 ,  A61K38/44 ,  A61K39/39558 ,  A61K2121/00 ,  C07K16/40 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/26 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y108/03002 ,  G01N33/5008 ,  G01N33/5011

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

Abstract translation: 本发明提供了通过施用静滴蛋白巯基氧化酶1（QSOX1）的抑制剂，包含这种抑制剂的组合物以及鉴定这种抑制剂的方法来进行肿瘤治疗的方法。

公开(公告)号：US09315547B2

公开(公告)日：2016-04-19

申请号：US14243923

申请日：2014-04-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony Seger ,  Dana Chuderland

IPC: A61K38/00 ,  A61K47/00 ,  C07K7/08 ,  C07K14/47 ,  C07K16/28 ,  C07K16/18 ,  C12N15/113

CPC classification number: C12N15/87 ,  A61K48/0041 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2319/09 ,  C12N15/113 ,  C12N2810/85

Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.

Abstract translation: 公开了包含核靶向活性或能够预防内源性核靶向活性的分离的肽。 编码相同的多核苷酸，包含其的药物组合物及其用途也被公开。

公开(公告)号：US09314483B2

公开(公告)日：2016-04-19

申请号：US14303212

申请日：2014-06-12

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ester Yoles ,  Ravid Shechter ,  Omer Miller

IPC: C12N5/0786 ,  A61K35/15 ,  A61K35/14 ,  A61K35/12

CPC classification number: A61K35/15 ,  A61K35/14 ,  A61K2035/124 ,  C12N5/0645

Abstract: A subpopulation of peripheral blood mononuclear cells (PBMCs) that is substantially devoid of CD3+ cells, CD19+ cells, CD56+ cells and optionally of CD16+ cells, for use in treatment of CNS injury is provided.

Abstract translation: 提供了用于治疗CNS损伤的基本上不含CD3 +细胞，CD19 +细胞，CD56 +细胞和任选的CD16 +细胞的外周血单核细胞（PBMC）的亚群。