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201 条记录 (耗时 0.037 秒)

    Cell Expansion
    51.
    发明申请
    Cell Expansion 审中-公开

    公开(公告)号：US20190119628A1

    公开(公告)日：2019-04-25

    申请号：US16302951

    申请日：2017-05-25

    申请人： Terumo BCT, Inc.

    发明人： Mark E. JONES

    IPC分类号： C12N5/00 ,  C12M1/12 ,  C12N5/0789 ,  A61K35/15 ,  C12M3/00 ,  C12M1/10

    摘要： Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other embodiments, the cells may be grown in co-culture with other cells, e.g., hMSC's. In embodiments, the cells may include CD34+cells.

    Expanding Cells in a Bioreactor
    53.
    发明申请
    Expanding Cells in a Bioreactor 审中-公开

    公开(公告)号：US20180282695A1

    公开(公告)日：2018-10-04

    申请号：US15943536

    申请日：2018-04-02

    申请人： Terumo BCT, Inc.

    发明人： Brian J. NANKERVIS ,  Domicinda M. HILL ,  Mark E. JONES

    IPC分类号： C12N5/0783 ,  C12M1/00

    摘要： Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.

    Coating a Bioreactor
    56.
    发明申请
    Coating a Bioreactor 审中-公开

    公开(公告)号：US20170349872A1

    公开(公告)日：2017-12-07

    申请号：US15616745

    申请日：2017-06-07

    申请人： Terumo BCT, Inc.

    发明人： Nathan D. FRANK

    IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M1/12 ,  C12M1/36

    摘要： Embodiments for coating a bioreactor with a reagent are described. The embodiments may provide for changing flow rates, direction of flow, and/or bioreactor rotation to enhance the coating of the bioreactor prior to growing cells in the bioreactor.

    Blood Bag System and Tube Holder
    58.
    发明申请
    Blood Bag System and Tube Holder 审中-公开
    血袋系统和管夹

    公开(公告)号：US20160317727A1

    公开(公告)日：2016-11-03

    申请号：US15108611

    申请日：2014-11-19

    申请人： TERUMO BCT, INC. ,  TERUMO KABUSHIKI KAISHA

    发明人： Makoto HIRABUKI ,  Tadashi IMAI

    IPC分类号： A61M1/02 ,  B04B5/04 ,  A61M1/36

    CPC分类号： A61M1/0218 ,  A61M1/0209 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/12 ,  B04B5/0428 ,  B04B2005/0435

    摘要： In order to prevent or suppress a blood component from being unnecessarily mixed to other bags by returning blood moved to a tube from a bag before centrifuge to the bag during the centrifuge. A blood bag system (10) has a cassette (50) (tube holder) for holding at least a part of the first transfer tube (21). The cassette (50) holds the first transfer tube (21) such that a distance between a rotation center (O) in application of a centrifugal force and the first transfer tube (21) increases toward the blood collection bag (11) side across a length between a flow path close position caused by the first clamp (71) in the first transfer tube (21) and the blood collection bag (11).

    摘要翻译： 为了防止或抑制血液成分不必要地与其他袋混合，将离心机离心前从袋中移出的血液返回到袋中。 血袋系统（10）具有用于保持第一输送管（21）的至少一部分的盒（50）（管夹持器）。 盒（50）保持第一传送管（21），使得施加离心力的旋转中心（O）与第一传送管（21）之间的距离朝向采血袋（11）侧朝着越过 由第一传送管（21）中的第一夹具（71）和血液收集袋（11）引起的流路闭合位置之间的长度。