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公开(公告)号：US06936454B2
公开(公告)日：2005-08-30
申请号：US10150293
申请日：2002-05-17
IPC分类号： C09K8/62 , C09K8/68 , E21B43/267 , C12N9/40
CPC分类号： E21B43/267 , C09K8/62 , C09K8/685 , Y10S507/921 , Y10S507/922 , Y10S507/923
摘要： A method of fracturing a subterranean formation which surrounds a well bore comprises the steps of providing a fracturing fluid, and injecting the fracturing fluid into the well bore at a pressure sufficient to form fractures in the subterranean formation which surrounds the well bore. The pressure is then released from the fracturing fluid, after which the fluid may be removed from the well and the well placed into production. The fracturing fluid comprises an aqueous liquid, a polysaccharide soluble or dispersible in the aqueous liquid in an amount sufficient to increase the viscosity of the aqueous liquid, an enzyme breaker which degrades said polysaccharide at a temperature above 180° F. Fracturing fluid compositions and enzyme breaker systems useful for carrying out the invention are also disclosed.
摘要翻译： 压裂围绕井眼的地下地层的方法包括提供压裂流体的步骤，以及足以在围绕井眼的地层中形成裂缝的压力将压裂流体注入井眼。 然后压力从压裂液中释放出来，然后可以将流体从井中移出并将井放入生产中。 压裂流体包含含水液体，在水性液体中可溶或可分散的多糖，其量足以增加水性液体的粘度，该酶在大于180°F的温度下降解所述多糖。压裂液组合物和酶 还公开了可用于实施本发明的断路器系统。
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公开(公告)号：US06428995B2
公开(公告)日：2002-08-06
申请号：US09742737
申请日：2000-12-21
IPC分类号： C12N940
CPC分类号： E21B43/267 , C09K8/62 , C09K8/685 , Y10S507/921 , Y10S507/922 , Y10S507/923
摘要： A method of fracturing a subterranean formation which surrounds a well bore comprises the steps of providing a fracturing fluid, and injecting the fracturing fluid into the well bore at a pressure sufficient to form fractures in the subterranean formation which surrounds the well bore. The pressure is then released from the fracturing fluid, after which the fluid may be removed from the well and the well placed into production. The fracturing fluid comprises an aqueous liquid, a polysaccharide soluble or dispersible in the aqueous liquid in an amount sufficient to increase the viscosity of the aqueous liquid, an enzyme breaker which degrades said polysaccharide at a temperature above 180° F. Fracturing fluid compositions and enzyme breaker systems useful for carrying out the invention are also disclosed.
摘要翻译： 压裂围绕井眼的地下地层的方法包括提供压裂流体的步骤，以及足以在围绕井眼的地层中形成裂缝的压力将压裂流体注入井眼。 然后压力从压裂液中释放出来，然后可以将流体从井中移出并将井放入生产中。 压裂流体包含含水液体，在水性液体中可溶或可分散的多糖，其量足以增加水性液体的粘度，该酶在大于180°F的温度下降解所述多糖。压裂液组合物和酶 还公开了可用于实施本发明的断路器系统。
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公开(公告)号：US06283997B1
公开(公告)日：2001-09-04
申请号：US09191606
申请日：1998-11-13
申请人： Rajeev Garg , Robert K. Prud'Homme , Ilhan A. Aksay , Victor F. Janas , Kevor S. TenHuisen , Shawn T. Huxel
发明人： Rajeev Garg , Robert K. Prud'Homme , Ilhan A. Aksay , Victor F. Janas , Kevor S. TenHuisen , Shawn T. Huxel
IPC分类号： A61F228
CPC分类号： G03F7/0037 , A61F2/28 , A61F2/30942 , A61F2/30965 , A61F2002/2825 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30915 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2210/0004 , A61F2250/0023 , A61F2310/00203 , A61F2310/00215 , A61F2310/00239 , A61F2310/00293 , A61F2310/00317 , A61L27/02 , A61L27/446 , B29C64/135 , B29K2709/02 , B33Y10/00 , B33Y80/00 , C04B38/067 , C04B2111/00836 , G05B2219/49008 , G05B2219/49013 , Y10S623/901 , C04B35/00 , C04B38/0054 , C04B41/0036
摘要： A process for producing a ceramic composite having a porous network. The process includes providing a photocurable ceramic dispersion. The dispersion consists of a photocurable polymer and a ceramic composition. The surface of the dispersion is scanned with a laser to cure the photocurable polymer to produce a photocured polymer/ceramic composition. The photocured composition useful as a polymer/ceramic composite, or the polymer phase can be removed by heating to a first temperature that is sufficient to burn out the photocured polymer. It is then heated to a second temperature that is higher than the first temperature and is sufficient to sinter the ceramic composition to produce a purely ceramic composition having a porous network. Preferably and more specifically, the process uses a stereolithographic technique for laser scanning. The process can form a high quality orthopedic implant that dimensionally matches the bone structure of a patient. The technique relies upon laser photocuring a dense colloidal dispersion into a desired complex three-dimensional shape. The shape is obtained from a CAT scan file of a bone and is rendered into a CAD file that is readable by the stereolithography instrument. Or the shape is obtained directly from a CAD file that is readable by the stereolithography instrument.
摘要翻译： 一种生产具有多孔网络的陶瓷复合材料的方法。 该方法包括提供可光固化的陶瓷分散体。 分散体由光固化聚合物和陶瓷组合物组成。 用激光扫描分散体的表面以固化光固化聚合物以产生光固化聚合物/陶瓷组合物。 可用作聚合物/陶瓷复合材料或聚合物相的光固化组合物可通过加热至足以烧尽光固化聚合物的第一温度来除去。 然后将其加热到高于第一温度的第二温度，并且足以烧结陶瓷组合物以产生具有多孔网络的纯陶瓷组合物。优选且更具体地，该方法使用用于激光扫描的立体光刻技术。 该过程可以形成与患者的骨骼结构尺寸匹配的高质量骨科植入物。 该技术依靠激光光固化稠密的胶体分散体成为所需的复杂三维形状。 该形状是从骨骼的CAT扫描文件中获得的，并被渲染成可由立体光刻仪器读取的CAD文件。 或者直接通过立体光刻仪可读的CAD文件获得形状。
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公开(公告)号：US06197730B1
公开(公告)日：2001-03-06
申请号：US09185120
申请日：1998-11-03
IPC分类号： C09K702
CPC分类号： E21B43/267 , C09K8/62 , C09K8/685 , Y10S507/921 , Y10S507/922 , Y10S507/923
摘要： A method of fracturing a subterranean formation which surrounds a well bore comprises the steps of providing a fracturing fluid, and injecting the fracturing fluid into the well bore at a pressure sufficient to form fractures in the subterranean formation which surrounds the well bore. The pressure is then released from the fracturing fluid, after which the fluid may be removed from the well and the well placed into production. The fracturing fluid comprises an aqueous liquid, a polysaccharide soluble or dispersible in the aqueous liquid in an amount sufficient to increase the viscosity of the aqueous liquid, an enzyme breaker which degrades the polysaccharide at a temperature above 180° F. Fracturing fluid compositions and enzyme breaker systems useful for carrying out the invention are also disclosed.
摘要翻译： 压裂围绕井眼的地下地层的方法包括提供压裂流体的步骤，以及足以在围绕井眼的地层中形成裂缝的压力将压裂流体注入井眼。 然后压力从压裂液中释放出来，然后可以将流体从井中移出并将井放入生产中。 压裂流体包含含水液体，可溶于或分散于含水液体中的多糖，其量足以增加水性液体的粘度，该酶在大于180°F的温度下降解多糖。压裂液组合物和酶 还公开了可用于实施本发明的断路器系统。
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公开(公告)号：US4754185A
公开(公告)日：1988-06-28
申请号：US919789
申请日：1986-10-16
CPC分类号： H02N1/004
摘要： Miniaturized linear and rotary electrostatic motors. The motors are fabricated by disposing a plurality of conductive lands onto insulating substrates and then filling in the spaces between the lands by deposition of an insulating material. A final layer of insulating material is then disposed over each of the entire surfaces containing the lands to form smooth bearing surfaces. The bearing surfaces of two of these elements are placed in contact. In one embodiment, the natural lubrication of the bearing surfaces aids movement. In another embodiment, a special lubricating film is placed between the substrates. Arrangements are made for maintaining alignment of the contacting elements. The lands are selectively energized in a manner to effect movement of one element with respect to the other.
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56.发明授权公开(公告)号：US09956179B2
公开(公告)日：2018-05-01
申请号：US13368888
申请日：2012-02-08
IPC分类号： A61K9/14 , A61K9/51 , A01N25/04 , A01N43/70 , A61K47/34 , B01F7/22 , B01F15/00 , B01J13/00 , B01F1/00
CPC分类号： A61K9/5138 , A01N25/04 , A01N43/70 , A61K9/5146 , A61K9/5192 , A61K47/34 , B01F1/00 , B01F7/22 , B01F15/00123 , B01F15/00344 , B01F15/00357 , B01F15/00376 , B01F15/00396 , B01J13/0021 , A01N2300/00
摘要： This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.
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公开(公告)号：US09943490B2
公开(公告)日：2018-04-17
申请号：US12265206
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Ying Liu
CPC分类号： A61K9/5153 , A61K49/0019 , A61K49/0065 , A61K49/0093 , A61K49/1857 , Y10T428/2991
摘要： The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.
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公开(公告)号：US20130037977A1
公开(公告)日：2013-02-14
申请号：US13639628
申请日：2011-04-07
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K9/1277
摘要： The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.
摘要翻译： 本发明提供了一种制备包封治疗产品的脂质纳米颗粒的方法，所述方法包括：a）在一个或多个储存器中提供一种或多种水溶液; b）在一个或多个储存器中提供一种或多种有机溶液，其中一种或多种有机溶液含有脂质，并且其中一种或多种水溶液和/或一种或多种有机溶液包括治疗产品; c）在第一混合区域中将所述一种或多种水溶液与所述一种或多种有机溶液混合，其中所述第一混合区域是多入口涡旋混合器（MIVM），其中所述一种或多种水溶液和所述一种或多种 将有机溶液切向引入MIVM内的混合室中，从而基本上即时产生含有包封治疗产品的脂质纳米颗粒的脂质纳米颗粒溶液。
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59.发明申请Process and Apparatuses for Preparing Nanoparticle Compositions with Amphiphilic Copolymers and Their Use 有权用两亲共聚物制备纳米颗粒组合物及其用途的方法和装置公开(公告)号：US20120171254A1
公开(公告)日：2012-07-05
申请号：US13368888
申请日：2012-02-08
CPC分类号： A61K9/5138 , A01N25/04 , A01N43/70 , A61K9/5146 , A61K9/5192 , A61K47/34 , B01F1/00 , B01F7/22 , B01F15/00123 , B01F15/00344 , B01F15/00357 , B01F15/00376 , B01F15/00396 , B01J13/0021 , A01N2300/00
摘要： This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.
摘要翻译： 本发明公开了一种通过闪蒸沉淀制备两亲性共聚物的纳米颗粒的方法。 纳米颗粒可以单独使用两亲性共聚物，也可以含有添加剂目标分子，优选为有机活性物质。 在两亲共聚物纳米颗粒中包含添加剂靶分子可以改变其水溶性特征，流体动力学和/或稳定性。 改变添加剂目标分子在纳米颗粒中的溶解度和稳定性可使得适合于药物给药的水不溶性化合物以及将该分子特异性地靶向患者身体的特定区域。 该方法以高绝对活性含量，高产率，高生产率和高加工速率生产纳米颗粒，同时使用异常少量的两亲性共聚物。 此外，所得到的颗粒根据需要显示出足够的后处理稳定性。 本发明还公开了通过闪蒸沉淀生产两亲性共聚物的纳米颗粒的两种装置。
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60.发明授权Gas storage cylinder formed from a composition containing thermally exfoliated graphite 有权由含有热剥离石墨的组合物形成的储气筒公开(公告)号：US08110524B2
公开(公告)日：2012-02-07
申请号：US12194043
申请日：2008-08-19
IPC分类号： C01B31/04
CPC分类号： H05K1/095 , B82Y30/00 , B82Y40/00 , C01B31/0423 , C01B31/043 , C01B31/0476 , C01B32/192 , C01B32/225 , C01B32/23 , C01B2204/32 , H01G4/206 , H05K3/0091 , H05K3/10 , H05K2201/0323 , Y02E60/324 , Y02E60/325 , Y02E60/328 , Y10T428/13 , Y10T428/1341 , Y10T428/1379 , Y10T428/2982
摘要： A gas storage cylinder or gas storage cylinder liner, formed from a polymer composite, containing at least one polymer and a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m2/g to 2600 m2/g.
摘要翻译： 包含至少一种聚合物和改性氧化石墨材料的由聚合物复合材料形成的储气罐或气体存储缸套，其是表面积为约300m 2 / g至2600m 2 / m 2的热剥离石墨氧化物， G。
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