公开(公告)号：US20230183261A1

公开(公告)日：2023-06-15

申请号：US17649906

申请日：2022-02-03

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Anthony Mastracchio ,  Xilu Wang ,  Cheng Ji ,  Michael D. Wendt ,  Xiaohong Song ,  George A. Doherty ,  Katja Jantos ,  Wilfried Braje ,  Andreas Kling ,  Frauke Pohlki ,  Thomas D. Penning

IPC: C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00 ,  A61P35/02

Abstract: The present disclosure provides for compounds of formula (I)




wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US10676485B2

公开(公告)日：2020-06-09

申请号：US15998789

申请日：2018-08-15

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Andrew J. Souers ,  Zhi-Fu Tao ,  Anthony Mastracchio ,  Xilu Wang ,  Cheng Ji ,  Michael D. Wendt ,  Xiaohong Song ,  George A. Doherty ,  Thomas D. Penning

IPC: A61K31/395 ,  A61P35/02 ,  C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00

Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20180140595A1

公开(公告)日：2018-05-24

申请号：US15803568

申请日：2017-11-03

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: A61K31/4725 ,  C07D401/04 ,  C07D417/14 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04 ,  A61K31/5377 ,  A61K31/5025 ,  A61K31/4985 ,  C07D471/04 ,  A61K31/541

CPC classification number: A61K31/4725 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US09844547B2

公开(公告)日：2017-12-19

申请号：US14961748

申请日：2015-12-07

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: A61K31/54 ,  A61K31/4725 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541

CPC classification number: A61K31/4725 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US20170158666A1

公开(公告)日：2017-06-08

申请号：US15219208

申请日：2016-07-25

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20160206611A1

公开(公告)日：2016-07-21

申请号：US14994824

申请日：2016-01-13

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: A61K31/4725 ,  A61K31/5377 ,  C07D417/14

CPC classification number: A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US09266877B2

公开(公告)日：2016-02-23

申请号：US14559828

申请日：2014-12-03

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: C07D417/14 ,  A61K31/4725 ,  A61K31/5377 ,  A61K45/06

CPC classification number: A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US09156856B2

公开(公告)日：2015-10-13

申请号：US13682603

申请日：2012-11-20

Applicant: AbbVie Inc.

Inventor： Aaron R. Kunzer ,  Steven W. Elmore ,  Laura A. Hexamer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M Sullivan ,  Gary T. Wang ,  Xilu Wang ,  Michael D. Wendt

IPC: C07C311/00 ,  C07D513/04 ,  C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D277/60 ,  C07D285/125 ,  C07D285/135 ,  C07D295/155 ,  C07D295/26 ,  C07D333/34 ,  C07D333/36 ,  C07D333/62 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D487/04 ,  C07D333/42

CPC classification number: C07D277/54 ,  C07C311/00 ,  C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D277/60 ,  C07D285/125 ,  C07D285/135 ,  C07D295/155 ,  C07D295/26 ,  C07D333/34 ,  C07D333/36 ,  C07D333/42 ,  C07D333/62 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20150152097A1

公开(公告)日：2015-06-04

申请号：US14559828

申请日：2014-12-03

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: C07D417/14

CPC classification number: A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

公开(公告)号：US09045444B2

公开(公告)日：2015-06-02

申请号：US14195666

申请日：2014-03-03

Applicant: AbbVie Inc.

Inventor： Hong Ding ,  Christopher L. Lynch ,  Xiaohong Song ,  Xilu Wang ,  Michael D. Wendt

IPC: C07D451/02 ,  C07D205/04 ,  C07D207/04 ,  C07D211/20 ,  C07D213/38 ,  C07D215/12 ,  C07D231/12 ,  C07D233/06 ,  C07D239/38 ,  C07D241/04 ,  C07D249/18 ,  C07D401/10 ,  C07D295/155 ,  C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/20 ,  C07D207/24 ,  C07D207/50 ,  C07D211/14 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/72 ,  C07D213/36 ,  C07D213/42 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D239/06 ,  C07D257/04 ,  C07D261/20 ,  C07D263/12 ,  C07D263/22 ,  C07D263/58 ,  C07D265/30 ,  C07D267/10 ,  C07D273/01 ,  C07D277/36 ,  C07D277/74 ,  C07D295/185 ,  C07D295/30 ,  C07D307/14 ,  C07D307/22 ,  C07D307/81 ,  C07D309/14 ,  C07D309/20 ,  C07D317/66 ,  C07D333/20 ,  C07D333/34 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D491/08 ,  C07D498/08 ,  C07C311/51 ,  C07D207/09 ,  C07D209/02 ,  C07D233/24 ,  C07D239/20 ,  C07D277/04 ,  C07D491/048 ,  C07D209/52 ,  C07D233/22

CPC classification number: C07D295/155 ,  C07C311/51 ,  C07D205/04 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/20 ,  C07D207/24 ,  C07D207/50 ,  C07D209/02 ,  C07D209/52 ,  C07D211/14 ,  C07D211/20 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/72 ,  C07D213/36 ,  C07D213/38 ,  C07D213/42 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D215/12 ,  C07D231/12 ,  C07D231/56 ,  C07D233/06 ,  C07D233/22 ,  C07D233/24 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D239/06 ,  C07D239/20 ,  C07D239/38 ,  C07D241/04 ,  C07D249/18 ,  C07D257/04 ,  C07D261/20 ,  C07D263/12 ,  C07D263/22 ,  C07D263/58 ,  C07D265/30 ,  C07D267/10 ,  C07D273/01 ,  C07D277/04 ,  C07D277/36 ,  C07D277/74 ,  C07D295/185 ,  C07D295/30 ,  C07D307/14 ,  C07D307/22 ,  C07D307/81 ,  C07D309/14 ,  C07D309/20 ,  C07D317/66 ,  C07D333/20 ,  C07D333/34 ,  C07D335/02 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/04 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D491/048 ,  C07D491/08 ,  C07D498/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。