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158 条记录 (耗时 0.039 秒)

    Silk-based drug delivery system
    52.
    发明授权
    Silk-based drug delivery system 有权
    丝绸药物输送系统

    公开(公告)号：US08178656B2

    公开(公告)日：2012-05-15

    申请号：US11628930

    申请日：2005-06-13

    申请人： David L. Kaplan ,  Meinel Lorenz

    发明人： David L. Kaplan ,  Meinel Lorenz

    IPC分类号： A61K38/17 ,  A61K9/22

    CPC分类号： A61K47/42 ,  A61K9/0002 ,  A61K9/7007 ,  A61K38/17 ,  A61K47/46

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

    Silk biomaterials and methods of use thereof
    53.
    发明授权
    Silk biomaterials and methods of use thereof 有权
    丝素生物材料及其使用方法

    公开(公告)号：US08071722B2

    公开(公告)日：2011-12-06

    申请号：US12688014

    申请日：2010-01-15

    申请人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    发明人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    IPC分类号： A61K38/00 ,  C07K14/00

    CPC分类号： D01D5/0038 ,  A61L27/227 ,  A61L27/3604 ,  D01F1/02 ,  D01F4/02 ,  D01F6/94 ,  D06M13/17 ,  D06M15/03 ,  D06M15/11 ,  A61L27/48 ,  C08L71/02 ,  A61L27/44

    摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

    摘要翻译： 本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。 在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。 我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。 此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

    SILK BIOMATERIALS AND METHODS OF USE THEREOF
    54.
    发明申请
    SILK BIOMATERIALS AND METHODS OF USE THEREOF 有权
    丝状生物材料及其使用方法

    公开(公告)号：US20100196447A1

    公开(公告)日：2010-08-05

    申请号：US12688014

    申请日：2010-01-15

    申请人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    发明人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    IPC分类号： A61K9/70 ,  A61K31/56 ,  A61K38/30 ,  A61K38/16 ,  A61K31/715 ,  A61K47/42 ,  A61P17/02

    CPC分类号： D01D5/0038 ,  A61L27/227 ,  A61L27/3604 ,  D01F1/02 ,  D01F4/02 ,  D01F6/94 ,  D06M13/17 ,  D06M15/03 ,  D06M15/11 ,  A61L27/48 ,  C08L71/02 ,  A61L27/44

    摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

    摘要翻译： 本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。 在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。 我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。 此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

    System and Apparatus for Collecting and Distributing Voluntary Environmental Impact Offset Payments on Fuel Purchases at Point of Sale
    59.
    发明申请
    System and Apparatus for Collecting and Distributing Voluntary Environmental Impact Offset Payments on Fuel Purchases at Point of Sale 审中-公开
    在销售点收集和分配自愿环境影响抵消支付燃料采购的系统和设备

    公开(公告)号：US20080249965A1

    公开(公告)日：2008-10-09

    申请号：US12049227

    申请日：2008-03-14

    申请人： Seth B. Pollack ,  David L. Kaplan ,  Seth W. Bridges

    发明人： Seth B. Pollack ,  David L. Kaplan ,  Seth W. Bridges

    IPC分类号： G06F17/00

    CPC分类号： G06Q30/0603 ,  G06Q50/06

    摘要： Systems and methods are described for collecting and distributing environmental impact offset payments at the point of sale of a fuel. An exemplary method presents a user interface at a point of sale of a purchase of a fuel, receives via the user interface a user-selection indicating an intention of the user to pay an environmental impact offset fee associated with the purchase, presents a choice to the user of making a custom offset payment or of buying a fuel that has the offset fee included in the price of the fuel, and calculates a custom offset payment for the purchase. The custom offset payment can be based on such considerations as an energy equivalency of the fuel purchased, volume or weight of the fuel being purchased, fuel type, fuel grade, e.g., octane level, oxygenation level, temperature of the fuel, fuel composition, climatic data, regional variation in fuel composition, efficiency of a vehicle receiving the fuel, pollution control capability of the vehicle receiving the fuel, and life-cycle environmental impacts of fuels, such as costs for extraction, processing, delivery, and combustion.

    摘要翻译： 描述了在燃料销售点收集和分配环境影响抵消支付的系统和方法。 示例性方法在购买燃料的销售点处呈现用户界面，经由用户界面接收指示用户支付与购买相关的环境影响抵消费用的意图的用户选择，向 用户进行自定义的抵消支付或购买燃料价格中包含抵消费用的燃料，并计算购买的定制抵消支付。 定制抵消支付可以基于以下考虑：所购买的燃料的能量等价物，所购燃料的体积或重量，燃料类型，燃料等级，例如辛烷值，氧合水平，燃料温度，燃料组成， 气候数据，燃料组成的区域变化，接收燃料的车辆的效率，接收燃料的车辆的污染控制能力以及燃料的生命周期环境影响，例如提取，处理，运送和燃烧的成本。

    Server architecture with detection and recovery of failed out-of-process application
    60.
    发明授权
    Server architecture with detection and recovery of failed out-of-process application 失效
    具有检测和恢复失败的进程外应用程序的服务器架构

    公开(公告)号：US06330689B1

    公开(公告)日：2001-12-11

    申请号：US09066504

    申请日：1998-04-23

    申请人： Lei Jin ,  David L. Kaplan ,  Murali R. Krishnan

    发明人： Lei Jin ,  David L. Kaplan ,  Murali R. Krishnan

    IPC分类号： G06F1100

    CPC分类号： G06F11/1415 ,  G06F11/1471

    摘要： A server architecture has a server program to receive client requests and multiple applications to process the requests. Each application comprises a collection of agents that can be invoked to process the requests and an application manager that manages the collection of agents. The agents within the associated collection are independent from, but dynamically accessible by, the application manager. Depending on the request, the application manager selects one or more agents to generate content to be returned to the client. An application manager director manages the application managers and facilitates delivery of the client requests from the server program to the suitable application. The application managers are independent from, but dynamically accessible by, the application manager director. For a given request, the director selects the appropriate application manager to handle the request. The application manager, in turn, selects the appropriate agent to process the request. The applications, including the agents and associated application managers, can be run either in-process or out-of-process with the server program. The server architecture has a detection and recovery subsystem that detects when an out-of-process application crashes and then recovers the application from that crash. The subsystem logs requests when they are passed to the out-of-process application, and remove the requests from the log when responses to the requests are returned from the application. If the out-of-process application crashes while one or more requests are outstanding, those requests remain listed on the log and thus readily identifiable. During recovery, the subsystem cleans up the outstanding requests until the log is cleared. Thereafter, the subsystem restarts the failed application to restore the service.

    摘要翻译： 服务器架构具有服务器程序来接收客户端请求和多个应用程序来处理请求。 每个应用程序包括可以调用以处理请求的代理的集合以及管理代理程序集合的应用程序管理器。 相关集合中的代理独立于应用程序管理器，但可由其进行动态访问。 根据请求，应用程序管理器选择一个或多个代理来生成要返回给客户端的内容。 应用程序管理器主管管理应用程序管理器，并有助于将客户端请求从服务器程序传递到合适的应用程序。 应用程序经理独立于应用程序经理主任，但可由其进行动态访问。 对于给定的请求，导演选择适当的应用程序管理器来处理请求。 反过来，应用程序管理器选择适当的代理来处理请求。 应用程序（包括代理程序和关联的应用程序管理器）可以通过服务器程序在进程内或进程内运行。 服务器体系结构具有一个检测和恢复子系统，用于检测进程外应用程序何时崩溃，然后从崩溃中恢复应用程序。 子系统在将请求传递到进程外应用程序时记录请求，并从应用程序返回对请求的响应时从日志中删除请求。 如果进程外应用程序在一个或多个请求未完成时崩溃，那么这些请求仍然列在日志中，因此可以很容易地识别。 在恢复期间，子系统清理未完成的请求，直到日志被清除。 此后，子系统重新启动失败的应用程序以恢复服务。