公开(公告)号：US20100173065A1

公开(公告)日：2010-07-08

申请号：US12683404

申请日：2010-01-06

Applicant: Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

Inventor： Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

IPC: A61K9/58

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L33/0029 ,  A61L33/0088 ,  A61L2300/42 ,  A61L2420/08

Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.

Abstract translation: 本发明涉及一种具有用于固定抗血栓形成材料如肝素的聚合底涂层的医疗装置。 粘合涂层由各种化学官能团组成，它们是稳定的并允许将抗血栓形成材料固定在其上。 还提供了将抗凝血栓塞材料固定在医疗装置表面上的底涂层内的方法。

公开(公告)号：US20100144635A1

公开(公告)日：2010-06-10

申请号：US12632612

申请日：2009-12-07

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M37/00 ,  A61M25/00 ,  A61K38/22 ,  A61K31/7088 ,  A61K47/34 ,  A61P9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US20090136556A1

公开(公告)日：2009-05-28

申请号：US12363538

申请日：2009-01-30

Applicant: Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

IPC: A61K9/00 ,  B05D3/00 ,  B05C13/02 ,  A61P35/00

CPC classification number: B05D3/0466 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D3/0473 ,  B05D3/048 ,  Y10T428/1393 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。

公开(公告)号：US07494665B1

公开(公告)日：2009-02-24

申请号：US10909795

申请日：2004-07-30

Applicant: Ni Ding ,  Stephen D. Pacetti

Inventor： Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/00

CPC classification number: C08G77/442 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L83/04

Abstract: A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了作为柔性单体和强度单体的硅氧烷的聚合物。 还提供了一种聚合物共混物，其包含由硅氧烷单体和强度单体形成的聚合物和另一种生物相容性聚合物。 本文所述的生物相容性聚合物或聚合物共混物和任选的生物活性剂可以在可植入装置如药物递送支架上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US07175873B1

公开(公告)日：2007-02-13

申请号：US10198898

申请日：2002-07-18

Applicant: Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

Inventor： Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

IPC: A61L33/10

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L29/04

Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.

Abstract translation: 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。

公开(公告)号：US20060246209A1

公开(公告)日：2006-11-02

申请号：US11395014

申请日：2006-03-31

Applicant: Andrew McNiven ,  Thomas Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed Hossainy

Inventor： Andrew McNiven ,  Thomas Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed Hossainy

IPC: A61L33/00

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  B05D3/107

Abstract: A method for modifying a polymeric coating on an implantable medical device, such as a stent, is disclosed. The method includes application of a fluid to a wet or dry polymeric coating with and without drugs.

Abstract translation: 公开了一种用于修改可植入医疗装置（例如支架）上的聚合物涂层的方法。 该方法包括将液体施用于具有和不具有药物的湿或干燥聚合物涂层。

公开(公告)号：US07011842B1

公开(公告)日：2006-03-14

申请号：US10177114

申请日：2002-06-21

Applicant: Murthy V Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Murthy V Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/626 ,  C08L77/04

Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.

Abstract translation: 描述了用于可植入医疗装置的聚阳离子肽涂层及其制造方法。 所述方法包括在所述装置上施加乳液，所述乳液包括聚合物和聚阳离子肽。 其他方法包括将聚阳离子肽掺入微球和脂质体中。

公开(公告)号：US20060014720A1

公开(公告)日：2006-01-19

申请号：US11228420

申请日：2005-09-15

Applicant: Syed Hossainy ,  Ni Ding

Inventor： Syed Hossainy ,  Ni Ding

IPC: A61K31/727 ,  A61K38/17 ,  C08B37/10

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

公开(公告)号：US20050215722A1

公开(公告)日：2005-09-29

申请号：US11057870

申请日：2005-02-14

Applicant: Leonard Pinchunk ,  Sepideh Hashemi ,  Marlene Schwarz ,  Kalpana Kamath ,  Ni Ding

Inventor： Leonard Pinchunk ,  Sepideh Hashemi ,  Marlene Schwarz ,  Kalpana Kamath ,  Ni Ding

IPC: A61K47/32 ,  A61K9/22 ,  A61K31/337 ,  A61K35/12 ,  A61K45/00 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K48/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61M37/00 ,  C08F2/00 ,  C08F293/00 ,  C08F297/00 ,  C08F297/04 ,  C08L53/00 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02

CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

Abstract: A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

Abstract translation: 提供了用于递送治疗剂的组合物。 所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。 嵌段共聚物优选为式X-（AB）n N，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。 弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。 根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。 医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。 根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。 根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层 包括上述生物相容性嵌段共聚物。

公开(公告)号：US20050208093A1

公开(公告)日：2005-09-22

申请号：US10807362

申请日：2004-03-22

Applicant: Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy ,  Ni Ding

Inventor： Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy ,  Ni Ding

IPC: A61L27/34 ,  A61L31/10 ,  C08G63/91 ,  A61K31/785 ,  A61K31/765 ,  C08G63/48

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/40 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  C08L33/14

Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法 提供了人类疾病的治疗。