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351 条记录 (耗时 0.034 秒)

    Introduction of modifying agents into skin by electroporation
    51.
    发明授权
    Introduction of modifying agents into skin by electroporation 失效
    通过电穿孔将改性剂引入皮肤

    公开(公告)号：US5911223A

    公开(公告)日：1999-06-15

    申请号：US695367

    申请日：1996-08-09

    申请人： James C. Weaver ,  Tani Chen ,  Christopher Cullander ,  Richard Guy ,  Robert S. Langer ,  Thomas E. Zewert ,  Uwe Pliquett ,  Rita Vanbever ,  Mark R. Prausnitz

    发明人： James C. Weaver ,  Tani Chen ,  Christopher Cullander ,  Richard Guy ,  Robert S. Langer ,  Thomas E. Zewert ,  Uwe Pliquett ,  Rita Vanbever ,  Mark R. Prausnitz

    IPC分类号： A61B17/00 ,  A61N1/32 ,  A61B19/00

    CPC分类号： A61N1/0424 ,  A61N1/325 ,  A61B2017/00765 ,  A61N1/0428 ,  Y10S607/901

    摘要： A method of modifying epidermis for transport of a material by electroporation includes applying to epidermis an agent that, upon entry into the epidermis, will modify the epidermis to thereby cause and altered rate of transport of a material across the epidermis. Typically, the altered rate will be an increased rate of transport. The epidermis is electroporated, whereby at least a portion of the modifying agent enters the electroporated epidermis, thereby modifying the epidermis to cause an altered rate of transport of a material across the epidermis. In another embodiment, the modifying agent can modify the epidermis to enable measurement and/or monitoring of physiological conditions or change within or beneath the epidermis. The modifying agents can also be employed to facilitate discharge of fluids from within an organism, such as by providing pathways for discharge of fluids from a tumor. Examples of modifying agents include: oxidizing agents; reducing agents; particles, such as optical indicator beads or beads that include drugs to be released into tissue; electrically-charged particles or molecules; etc. Materials that can be transported by the method of the invention include, for example, proteins, nucleic acids, electrically charged molecules or particles, microorganisms suitable for immunization, etc. Also, tissues other than skin can be employed in the method of the invention.

    摘要翻译： 通过电穿孔来改变用于运输材料的表皮的方法包括向表皮施加一种在进入表皮时将改变表皮从而引起和改变材料穿过表皮的运输速率的试剂。 通常，改变率将是增加的运输速度。 表皮被电穿孔，由此至少一部分改性剂进入电穿孔表皮，从而改变表皮，导致材料穿过表皮的转运速率。 在另一个实施方案中，修饰剂可以修饰表皮以使得能够测量和/或监测生理条件或在表皮内或下表面的变化。 还可以使用改性剂来促进从生物体内排出流体，例如通过提供从肿瘤排出流体的途径。 改性剂的实例包括：氧化剂; 还原剂; 颗粒，例如包括要释放到组织中的药物的光学指示剂珠粒或珠粒; 带电粒子或分子; 可以通过本发明的方法传输的材料包括例如蛋白质，核酸，带电分子或颗粒，适合免疫的微生物等。另外，皮肤以外的组织可以用于 发明。

    Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
    54.
    发明授权
    Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue 失效
    植入细胞基质结构邻近肠系膜，网膜或腹膜组织

    公开(公告)号：US5804178A

    公开(公告)日：1998-09-08

    申请号：US203509

    申请日：1994-02-28

    申请人： Joseph P. Vacanti ,  Robert S. Langer ,  Lynt Johnson

    发明人： Joseph P. Vacanti ,  Robert S. Langer ,  Lynt Johnson

    IPC分类号： A61L27/36 ,  A61L27/38 ,  C12N5/00 ,  C12N11/08 ,  A61F2/18 ,  A61F2/28

    CPC分类号： A61L27/3839 ,  A61L27/3843 ,  A61L27/3869 ,  C12N5/0068 ,  A61L2430/06 ,  C12N2501/18 ,  C12N2533/30 ,  C12N2533/40

    摘要： A matrix structure containing attached cells such as endocrine cells, fibroblasts, endothelial cells or genitourinary cells is implanted in a patient adjacent tissue having a high surface area and vasculature such as mesentery, omentum or peritoneum tissue. Large volumes of cells can be attached to the matrix and the matrix implanted with minimum trauma and blood loss into a patient to produce a functional organ equivalent. Multiple matrix structures containing cells can be implanted to functionally resemble naturally occurring organs. Implanting multiple matrices between folds of the mesentery is particularly well suited for growth of endocrine structures, including liver, pancreas, and adrenal gland. The matrix structure is preferably formed from a biodegradable artificial polymer. Collagen and non-biodegradable materials can also be used, and the matrix structure can be overlaid with a material that enhances cell attachment. Materials such as angiogenesis factors can be incorporated into a matrix and implanted prior to implanting the matrix containing cells or the materials can be incorporated into the matrix containing cells. Cells attached to the matrix may be cultured in vitro prior to implanting. Matrix structures containing different types of cells can be implanted juxtapositioned with each other.

    摘要翻译： 将包含附着细胞如内分泌细胞，成纤维细胞，内皮细胞或泌尿生殖细胞的基质结构植入具有高表面积和脉管系统如肠系膜，网膜或腹膜组织的邻近组织中。 大量的细胞可以连接到基质上，并且基质以最小的创伤和失血植入患者体内以产生功能性器官当量。 可以将包含细胞的多个基质结构植入功能上类似天然存在的器官。 在肠系膜的折叠之间植入多个基质特别适用于内分泌结构的生长，包括肝，胰腺和肾上腺。 基质结构优选由生物可降解的人造聚合物形成。 还可以使用胶原蛋白和不可生物降解的材料，并且可以用增强细胞附着的材料覆盖基质结构。 诸如血管生成因子的材料可以掺入基质中并在植入包含细胞的基质之前植入，或者该材料可以并入含有基质的细胞中。 附着于基质的细胞可以在植入前在体外培养。 含有不同类型细胞的基质结构可以彼此并置。

    Microspheres comprising polymer and drug dispersed there within
    55.
    发明授权
    Microspheres comprising polymer and drug dispersed there within 失效
    包含分散在其中的聚合物和药物的微球

    公开(公告)号：US5718921A

    公开(公告)日：1998-02-17

    申请号：US691874

    申请日：1996-08-02

    申请人： Edith Mathiowitz ,  Claudy J.P. Mullon ,  Abraham J. Domb ,  Robert S. Langer

    发明人： Edith Mathiowitz ,  Claudy J.P. Mullon ,  Abraham J. Domb ,  Robert S. Langer

    IPC分类号： A61K9/50 ,  B01J13/02 ,  A61K9/52 ,  B01J13/12

    CPC分类号： B01J13/02 ,  A61K9/5031 ,  Y10S514/866 ,  Y10S514/963 ,  Y10S514/965

    摘要： A method for preparation of biodegradable polymeric drug delivery devices using relatively low temperatures and non-aqueous solutions which is particularly useful with polyanhydrides, thermolabile drugs, and in forming multi-layered devices. In a first embodiment, the polymer is dissolved in a volatile organic solvent, the drug is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic oil, and the organic solvent is extracted into the oil, creating microspheres. The preferred polymers are polyanhydrides since they are biodegradable and have been proven to be useful in vivo. In a second embodiment, the polymer is dissolved in organic solvent with or without the drug, and the mixture is suspended in glycerol. The suspension is frozen and the organic solvent slowly evaporated. Using these embodiments, alone or in combination with other methods including the "hot melt" technique, multi-walled microspheres having each wall degrading at a different rate or containing different drugs can be manufactured.

    摘要翻译： 一种使用相对较低温度制备可生物降解的聚合物药物递送装置的方法以及非常适用于聚酐，不耐热药物和形成多层装置的非水溶液。 在第一实施方案中，将聚合物溶解在挥发性有机溶剂中，将药物分散或溶解在聚合物溶液中，将混合物悬浮在有机油中，并将有机溶剂萃取到油中，形成微球体。 优选的聚合物是聚酐，因为它们是可生物降解的并且已被证明在体内是有用的。 在第二个实施方案中，将聚合物溶解在有或者没有药物的有机溶剂中，并将混合物悬浮在甘油中。 将悬浮液冷冻并缓慢蒸发有机溶剂。 使用这些实施方案，可单独使用或与包括“热熔融”技术在一起的其它方法结合使用，可以制造具有以不同速率降解或含有不同药物的各壁的多壁微球体。

    Controlled local delivery of chemotherapeutic agents for treating solid tumors
    57.
    发明授权
    Controlled local delivery of chemotherapeutic agents for treating solid tumors 失效
    用于治疗实体瘤的化疗药物的局部控制

    公开(公告)号：US5626862A

    公开(公告)日：1997-05-06

    申请号：US284341

    申请日：1994-08-02

    申请人： Henry Brem ,  Robert S. Langer ,  Abraham J. Domb

    发明人： Henry Brem ,  Robert S. Langer ,  Abraham J. Domb

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K31/282 ,  A61K31/337 ,  A61K31/47 ,  A61K31/4745 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/34 ,  A61K31/335

    CPC分类号： A61K9/0085 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/555 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/204

    摘要： A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.

    摘要翻译： 描述了用于将化学治疗剂局部递送至实体瘤的方法和装置，其中所述药物不穿过血脑屏障并且其特征在于体内生物利用度差和/或半衰期短。 这些装置包括在延长的时间段内释放药物的储存器，同时保持药剂的生物活性和生物利用度。 在最优选的实施方案中，该装置由可生物降解的聚合物基质组成，尽管储存器也可以由与植入的输注泵连接的不可生物降解的聚合物或储存器配制。 这些装置被植入到待治疗的肿瘤内或紧邻其中，或被手术切除的部位。 这些实施例证明分别通过压缩成型可生物降解和不可生物降解的聚合物制备的聚合物植入物中递送的紫杉醇和喜树碱的功效。 结果具有很高的统计学意义。