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    Porous biodegradable polymeric materials for cell transplantation
    6.
    发明授权
    Porous biodegradable polymeric materials for cell transplantation 失效
    用于细胞移植的多孔可生物降解聚合物材料

    公开(公告)号：US07462471B2

    公开(公告)日：2008-12-09

    申请号：US10775768

    申请日：2004-02-10

    申请人： Antonios G. Mikos ,  Joseph P. Vacanti ,  Robert S. Langer ,  Linda G. Griffith ,  Georgios Sarakinos

    发明人： Antonios G. Mikos ,  Joseph P. Vacanti ,  Robert S. Langer ,  Linda G. Griffith ,  Georgios Sarakinos

    IPC分类号： C12N11/08 ,  C12N11/04 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  A61F2/00

    CPC分类号： G02B27/0031 ,  A61L27/18 ,  A61L27/56 ,  A61L2400/06 ,  G03F7/40 ,  H01L21/0273 ,  H01L21/32139 ,  C08L67/04

    摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.

    摘要翻译： 聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。 通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。 引入的细胞附着到基质内的结缔组织，并由血管进食。 用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。 随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。 组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。 前进组织的血管分布与时间一致，与生物材料组成和形态无关。