公开(公告)号：US20050233062A1

公开(公告)日：2005-10-20

申请号：US10856984

申请日：2004-05-27

Applicant: Syed Hossainy ,  Yiwen Tang ,  Manish Gada

Inventor： Syed Hossainy ,  Yiwen Tang ,  Manish Gada

IPC: A61F2/00 ,  A61F2/82 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00 ,  A61F2/06

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2420/02 ,  B29C71/02 ,  C08L67/04

Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.

Abstract translation: 公开了一种制造可植入医疗装置的方法，例如药物洗脱支架。 该方法包括使包含聚合物的可植入医疗装置经受热条件。 加热条件可导致活性剂从植入装置之后的装置释放速率降低，和/或改善装置上的聚合物涂层的机械性能。

公开(公告)号：US20050191332A1

公开(公告)日：2005-09-01

申请号：US11053184

申请日：2005-02-07

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61F2/02 ,  A61K31/4745 ,  A61L2/00 ,  A61L15/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00 ,  B32B27/18 ,  B32B27/30 ,  B32B27/36

CPC classification number: A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T428/31935

Abstract: A method is disclosed for forming a coating on implantable medical devices including an interpenetrating polymer network that serves as a rate limiting barrier.

Abstract translation: 公开了用于在可植入医疗装置上形成涂层的方法，其包括用作限速屏障的互穿聚合物网络。

公开(公告)号：US20050107864A1

公开(公告)日：2005-05-19

申请号：US11020826

申请日：2004-12-22

Applicant: James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K.T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

Inventor： James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K.T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

IPC: A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61L31/10 ,  A61L31/16 ,  A61F2/06

CPC classification number: A61F2/915 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  Y10S623/901

Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

公开(公告)号：US06866805B2

公开(公告)日：2005-03-15

申请号：US10033380

申请日：2001-12-27

Applicant: James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K.T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

Inventor： James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K.T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

IPC: A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61L31/10 ,  A61L31/16 ,  B29C45/14 ,  B29C70/70

CPC classification number: A61F2/915 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  Y10S623/901

Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

Abstract translation: 形成具有高柔性和高径向强度的混合支架。 用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。

公开(公告)号：US20050033411A1

公开(公告)日：2005-02-10

申请号：US10911968

申请日：2004-08-04

Applicant: Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

Inventor： Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC classification number: A61F2/0077 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61F2250/0068 ,  Y10S623/901

Abstract: An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.

Abstract translation: 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。

公开(公告)号：US20050025799A1

公开(公告)日：2005-02-03

申请号：US10630261

申请日：2003-07-30

Applicant: Syed Hossainy ,  Eugene Michal ,  Yiwen Tang

Inventor： Syed Hossainy ,  Eugene Michal ,  Yiwen Tang

IPC: A61L31/10 ,  A61L31/16 ,  A61F2/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/606 ,  C08L67/04 ,  C08L71/02

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。 生物活性剂可以与嵌段共聚物缀合。

公开(公告)号：US06764505B1

公开(公告)日：2004-07-20

申请号：US09834012

申请日：2001-04-12

Applicant: Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

Inventor： Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

IPC: A61F208

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0095 ,  A61F2230/0013 ,  A61F2250/0025 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.

Abstract translation: 由支架支柱确定的可变表面积的支架。 支架可以具有容纳治疗剂的每单位长度的可变表面积。 可以在整个支架中提供治疗剂的图案化分布。 支架可以在支架的端部附近具有增加的治疗剂水平。 在支架的一个实施方案的末端附近可以提供降低的治疗剂水平。 可以在支架的表面设置缺陷，其中设置有治疗剂。 可以用可变厚度的支柱切割支架，以提供可变的支架表面积。

公开(公告)号：US06465001B1

公开(公告)日：2002-10-15

申请号：US09033871

申请日：1998-03-03

Applicant: Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy ,  Jennifer L. Hill-West

Inventor： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy ,  Jennifer L. Hill-West

IPC: A61F200

CPC classification number: C12N11/04 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61K38/42 ,  A61K38/44 ,  A61K47/645 ,  A61K47/6903 ,  A61K47/6927 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B82Y5/00 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10S514/801 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/817 ,  Y10T428/2987 ,  Y10T428/2989 ,  C08L71/02

Abstract: Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, and coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules. A medical condition at a localized site is treated by applying a polymerization initiator and then applying a substantially water-soluble, degradable macromer of at least 200 mw and having at least two crosslinkable substituents, and polymerizing the macromer to form a crosslinked polymeric material at the site. The crosslinked polymeric material may adhere two surfaces together, or be a barrier that provides immunoisolation or prevents adhesion of the site to another surface such as post-surgical adhesion. A biologically active material may be present when the macromer is polymerized to provide for delivery of the biologically active material, or to provide the polymeric material with a desired property such as resistance to bacterial growth or a decrease in inflammatory response.

Abstract translation: 通过添加可自由基聚合的基团（例如含有碳 - 碳双键或三键的那些基团）来修饰水溶性大分子单体，其可在温和条件下聚合以包封组织，细胞或生物活性材料。 聚合物材料特别可用作组织粘合剂，包括血管的组织腔的涂层，诸如朗格汉斯岛的细胞的涂层，以及用于与生物材料如身体接触的涂层，塞子，支撑体或基底，以及作为药物递送装置 用于生物活性分子。 通过施加聚合引发剂然后施加至少200mw的基本上水溶性的可降解的大分子单体并且具有至少两个可交联取代基来处理局部位点处的医学状况，并聚合大分子单体以形成交联的聚合物材料 现场。 交联的聚合物材料可以将两个表面粘合在一起，或者是提供免疫隔离或防止位点粘附到另一表面的屏障，例如手术后粘连。 当大分子单体聚合以提供生物活性材料的递送时，或者为聚合物材料提供所需性质，例如耐细菌生长或炎症反应降低时，可存在生物活性物质。

公开(公告)号：US09242005B1

公开(公告)日：2016-01-26

申请号：US11507860

申请日：2006-08-21

Applicant: Syed Hossainy ,  Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny ,  Fozan El-Nounou ,  Thierry Glauser ,  Jessica DesNoyer

Inventor： Syed Hossainy ,  Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny ,  Fozan El-Nounou ,  Thierry Glauser ,  Jessica DesNoyer

IPC: A61M31/00 ,  A61K47/42 ,  A61K47/48 ,  A61M5/178

CPC classification number: A61K47/42 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/1273 ,  A61M5/178 ,  A61M25/104 ,  A61M31/00 ,  A61M2025/0087 ,  A61M2025/105 ,  A61M2025/1052

Abstract: Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.

Abstract translation: 本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。 在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。 在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。 在一些应用中，前修复剂可以帮助恢复内皮功能。 制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。

公开(公告)号：US20140018903A1

公开(公告)日：2014-01-16

申请号：US13549366

申请日：2012-07-13

Applicant: Erik David Eli ,  Michael Huy Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Dariush Davalian

Inventor： Erik David Eli ,  Michael Huy Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Dariush Davalian

IPC: A61F2/82

CPC classification number: A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0054

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings.

Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架具有当植入在外周血管内时产生较低的晚期管腔损失并且也表现出高的轴向疲劳寿命的结构。 在优选实施例中，支架形成通过连杆互连的环形结构，其中环具有12个冠部，并且至多两个连接相邻环件的连杆。