公开(公告)号：US07381405B2

公开(公告)日：2008-06-03

申请号：US10531145

申请日：2002-10-15

申请人： Ke Liu ,  Steven A. Rosenberg

发明人： Ke Liu ,  Steven A. Rosenberg

IPC分类号： A01N63/00 ,  A61K39/00 ,  C12N15/00 ,  C12N15/63 ,  C07H21/04

CPC分类号： A61K39/0011 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N2510/00

摘要： The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs) from a patient immunized with an antigen of the cancer, stimulating the PBMCs with the antigen of the cancer in vitro, transducing the PBMCs with a retroviral vector, which (a) comprises and expresses a human interleukin-2 (IL-2) coding sequence operably linked to a retroviral promoter, (b) does not comprise an exogenously introduced gene that enables phenotypic selection, and (c) comprises a viral envelope that efficiently transduces CD8+ T-lymphocytes; compositions comprising cells obtained in accordance with such methods; and methods of treating a patient having cancer by administering to the patient cells obtained in accordance with such methods or compositions comprising same.

摘要翻译： 本发明提供了制备自体T淋巴细胞以重新导入具有癌症的患者的方法，该方法包括从用癌抗原免疫的患者获得外周血单核细胞（PBMC），用抗原的抗原刺激PBMC （a）包含并表达与逆转录病毒启动子可操作地连接的人白细胞介素-2（IL-2）编码序列，（b）不包含外源导入的基因，其使得能够 表型选择，和（c）包含有效转导CD8 + T淋巴细胞的病毒包膜; 包含根据这些方法获得的细胞的组合物; 以及通过给予根据这样的方法获得的患者细胞治疗患有癌症的患者的方法或组合物的方法。

公开(公告)号：US20080112867A1

公开(公告)日：2008-05-15

申请号：US11558063

申请日：2006-11-09

申请人： Wei Wei ,  James Anthony Ruud ,  Anthony Yu-Chung Ku ,  Vidya Ramaswamy ,  Ke Liu

发明人： Wei Wei ,  James Anthony Ruud ,  Anthony Yu-Chung Ku ,  Vidya Ramaswamy ,  Ke Liu

IPC分类号： B01D53/62

CPC分类号： C01B3/16 ,  B01J19/2475 ,  B01J19/2485 ,  B01J2219/00108 ,  B01J2219/00123 ,  B01J2219/1946 ,  C01B3/501 ,  C01B2203/0283 ,  C01B2203/0405 ,  C01B2203/0475 ,  C01B2203/0485 ,  C01B2203/1064 ,  C01B2203/84 ,  C01B2203/86 ,  Y02C10/04 ,  Y02C10/10 ,  Y02P30/30 ,  Y10S48/05

摘要： An apparatus for producing hydrogen gas wherein the apparatus includes a reactor. In one embodiment, the reactor includes at least two conversion-removal portions. Each conversion-removal portion comprises a catalyst section configured to convert CO in the stream to CO2 and a membrane section located downstream of and in flow communication with the catalyst section. The membrane section is configured to selectively remove the CO2 from the stream and to be in flow communication with a sweep gas.

摘要翻译： 一种生产氢气的装置，其中装置包括一个反应器。 在一个实施方案中，反应器包括至少两个转化除去部分。 每个转化除去部分包括催化剂部分，其构造成将物流中的CO转化为CO 2，以及位于催化剂部分下游并与催化剂部分流动连通的膜部分。 膜部分构造成从流中选择性地去除CO 2并与吹扫气体流动连通。

公开(公告)号：US20070128485A1

公开(公告)日：2007-06-07

申请号：US11292584

申请日：2005-12-02

申请人： Ji-Cheng Zhao ,  Ke Liu

发明人： Ji-Cheng Zhao ,  Ke Liu

IPC分类号： H01M8/04 ,  H01M8/10

CPC分类号： H01M8/04089 ,  H01M8/04022 ,  H01M8/04037 ,  H01M8/04216 ,  H01M8/04268 ,  H01M8/0662 ,  H01M8/083

摘要： A fuel cell system comprises a hydrogen storage system for storing and releasing hydrogen, a fuel cell in fluid communication with the hydrogen storage system for receiving released hydrogen from the hydrogen storage system and for electrochemically reacting the hydrogen with an oxidant to produce electricity and an anode exhaust. A catalytic combustor is in fluid communication with the fuel cell for receiving the anode exhaust and for catalytically reacting the anode exhaust to produce an offgas having an elevated temperature that is greater than the temperature of the anode exhaust. The heat from the offgas is used to release the hydrogen from the hydrogen storage system. An electrical heater is coupled to the catalytic combustor to enable cold start of the fuel cell and the storage system.

摘要翻译： 燃料电池系统包括用于储存和释放氢的氢存储系统，与氢存储系统流体连通的用于从氢存储系统接收释放的氢并用于使氢与氧化剂电化学反应以产生电的燃料电池和阳极 排气。 催化燃烧器与用于接收阳极排气的燃料电池流体连通，并且用于使阳极排气催化反应以产生具有大于阳极排气温度的高温的废气。 来自废气的热量用于从氢存储系统释放氢。 电加热器耦合到催化燃烧器以实现燃料电池和存储系统的冷起动。

公开(公告)号：US20070122339A1

公开(公告)日：2007-05-31

申请号：US11287644

申请日：2005-11-28

申请人： Parag Kulkarni ,  Richard Bourgeois ,  Ke Liu ,  Ravi Sathya Vipperla ,  Vladimir Zamansky

发明人： Parag Kulkarni ,  Richard Bourgeois ,  Ke Liu ,  Ravi Sathya Vipperla ,  Vladimir Zamansky

IPC分类号： C01B3/26 ,  C25C1/02 ,  B01J8/04 ,  C25B9/00

CPC分类号： C25B1/04 ,  C01B3/386 ,  C01B3/48 ,  C01B2203/0261 ,  C01B2203/0288 ,  C01B2203/044 ,  C01B2203/047 ,  C01B2203/0475 ,  C01B2203/0495 ,  C01B2203/06 ,  C01B2203/147 ,  C01B2203/84 ,  Y02E60/366

摘要： An apparatus for producing hydrogen (H2) includes an electrolyzer configured to produce H2 gas from steam and a catalytic partial oxidation (CPO) reformer. The CPO reformer is coupled to the electrolyzer and configured to utilize byproducts of the electrolyzer as input to produce more H2. The electrolyzer is coupled to the CPO reformer to utilize steam and heat byproducts from the CPO reformer as input to the electrolyzer.

摘要翻译： 一种生产氢气（H2）的装置包括一个电解槽，其被配置为从蒸汽和催化部分氧化（CPO）重整器中产生H2气。 CPO重整器耦合到电解器并且被配置为利用电解器的副产物作为输入以产生更多的H 2。 电解槽连接到CPO重整器，以利用来自CPO重整器的蒸汽和热副产物作为电解槽的输入。

公开(公告)号：US20070072949A1

公开(公告)日：2007-03-29

申请号：US11263269

申请日：2005-10-31

申请人： James Ruud ,  Jennifer Molaison ,  Louis Schick ,  Anthony Yu-Chung Ku ,  Ke Liu ,  Parag Kulkarni ,  R. Rizeq

发明人： James Ruud ,  Jennifer Molaison ,  Louis Schick ,  Anthony Yu-Chung Ku ,  Ke Liu ,  Parag Kulkarni ,  R. Rizeq

IPC分类号： C07C27/06 ,  F02C3/30

CPC分类号： F02C3/28 ,  B01D53/229 ,  B01D2257/304 ,  B01D2257/504 ,  B01D2313/38 ,  B01D2325/22 ,  B01J8/067 ,  B01J19/2475 ,  B01J2208/00141 ,  C01B3/16 ,  C01B3/52 ,  C01B3/56 ,  C01B2203/0415 ,  C01B2203/0475 ,  C01B2203/0485 ,  C10J3/00 ,  C10J3/82 ,  C10J2300/093 ,  C10J2300/0959 ,  C10J2300/0973 ,  C10J2300/165 ,  C10J2300/1687 ,  F05D2220/72 ,  Y02C10/10 ,  Y02E20/16 ,  Y02E20/18 ,  Y02P20/152

摘要： An apparatus for producing hydrogen gas, wherein the apparatus includes a reactor. The reactor includes a catalyst, a membrane in flow communication with the catalyst, and a heat exchanger integrated with the reactor.

摘要翻译： 一种生产氢气的设备，其中该设备包括反应器。 反应器包括催化剂，与催化剂流动连通的膜和与反应器整合的热交换器。

公开(公告)号：US07195742B2

公开(公告)日：2007-03-27

申请号：US10207704

申请日：2002-07-26

申请人： Ke Liu ,  Sean C. Emerson ,  Richard James Bellows

发明人： Ke Liu ,  Sean C. Emerson ,  Richard James Bellows

IPC分类号： B01D50/00 ,  B01D53/34 ,  B01D53/94 ,  F28D21/00 ,  B01J7/00

CPC分类号： C01B3/583 ,  B01J8/0407 ,  B01J8/0492 ,  B01J8/0496 ,  B01J2208/00212 ,  C01B2203/0205 ,  C01B2203/044 ,  C01B2203/047 ,  H01M8/0612

摘要： An apparatus for preferential oxidation of carbon monoxide in a reformate flow includes a reactor defining a flow path for a reformate flow; at least one catalyst bed disposed along the flow path; and a distributor for distributing oxygen from an oxygen source to the at least one catalyst bed, the distributor including a conduit positioned at least one of upstream of and through the at least one catalyst bed, the conduit having a sidewall permeable to flow of oxygen from within the conduit to the at least one catalyst bed.

摘要翻译： 用于重整产品流中一氧化碳优先氧化的装置包括限定重整流程流动路径的反应器; 沿着流路设置的至少一个催化剂床; 以及用于将氧从氧源分配到所述至少一个催化剂床的分配器，所述分配器包括定位在所述至少一个催化剂床的上游和穿过所述至少一个催化剂床中的至少一个的导管，所述导管具有可渗透氧气流的侧壁 在至少一个催化剂床的导管内。

公开(公告)号：US20070026272A1

公开(公告)日：2007-02-01

申请号：US11292583

申请日：2005-12-02

申请人： Ke Liu ,  Ji-Cheng Zhao

发明人： Ke Liu ,  Ji-Cheng Zhao

IPC分类号： H01M8/06

CPC分类号： C01B3/0026 ,  C01B3/0078 ,  H01M8/04022 ,  H01M8/04097 ,  H01M8/04208 ,  H01M8/065 ,  H01M8/083 ,  H01M8/086 ,  H01M2008/1095 ,  H01M2008/1293 ,  Y02E60/327

摘要： A fuel cell system comprises a hydrogen storage system for storing and releasing hydrogen, a fuel cell in fluid communication with the hydrogen storage system for receiving released hydrogen from the hydrogen storage system and for electrochemically reacting the hydrogen with an oxidant to produce electricity and an anode exhaust. A catalytic combustor is in fluid communication with the fuel cell for receiving the anode exhaust and for catalytically reacting the anode exhaust to produce an offgas having an elevated temperature that is greater than the temperature of the anode exhaust. The heat from the offgas is used to release the hydrogen from the hydrogen storage system.

公开(公告)号：US20060260364A1

公开(公告)日：2006-11-23

申请号：US11132359

申请日：2005-05-18

申请人： Edwin Pun ,  Ke Liu

发明人： Edwin Pun ,  Ke Liu

IPC分类号： C03B37/022 ,  C03C13/00 ,  C03C27/00

CPC分类号： G02B6/1345 ,  C03C25/603

摘要： A method for forming buried ion-exchanged waveguides involves a two-step process. In a first step a waveguide is formed at the surface of a substrate using an ion-exchange technique. After formation of the waveguide, a field-assisted annealing is carried out to move the waveguide away from the surface of the substrate so that it is buried in the substrate. Exemplary field-assisted annealing is carried out at a temperature close to the ion-exchange temperature ±10° C. to optimize results.

摘要翻译： 用于形成掩埋离子交换波导的方法涉及两步法。 在第一步骤中，使用离子交换技术在衬底的表面处形成波导。 在形成波导之后，进行场辅助退火以使波导远离衬底的表面，使其被埋在衬底中。 示例性的场辅助退火在接近离子交换温度±10℃的温度下进行，以优化结果。

公开(公告)号：US20060241393A1

公开(公告)日：2006-10-26

申请号：US11323668

申请日：2005-12-30

申请人： Ke Liu ,  Ting Xue ,  Jian Wang

发明人： Ke Liu ,  Ting Xue ,  Jian Wang

IPC分类号： A61B5/05

CPC分类号： G01R33/34046 ,  A61B5/0555

摘要： A rotation positioning device for a coil of a magnetic resonance imaging apparatus, having a cavity in the coil for accommodating a part to be examined, has a backing member that can freely rotate within this accommodating cavity. The backing member is provided with a first driving member and a first rotating member, and the coil is provided with a second driving member and a second rotating member. The first driving member and the second driving member form a transmission pair, and the first rotating member can rotate relative to the second rotating member under the drive of the first driving member and the second driving member. The second driving member can be driven manually or by an external driving source connected thereto to drive the first driving member, thereby driving the backing member to rotate via the cooperation of the first rotating member and the second rotating member. Also, by appropriate configuration of parameters, such as position and size, of the first driving member and the second driving member, the rotation angle or range of the backing member can be controlled precisely and quantitatively.

摘要翻译： 用于磁共振成像装置的线圈的旋转定位装置具有用于容纳待检查部件的线圈中的空腔，具有能够在该容纳腔内自由旋转的背衬构件。 背衬构件设置有第一驱动构件和第一旋转构件，线圈设置有第二驱动构件和第二旋转构件。 第一驱动构件和第二驱动构件形成传动对，并且第一旋转构件可以在第一驱动构件和第二驱动构件的驱动下相对于第二旋转构件旋转。 第二驱动构件可以手动地或通过与其连接的外部驱动源来驱动以驱动第一驱动构件，从而通过第一旋转构件和第二旋转构件的协作来驱动背衬构件旋转。 此外，通过适当配置第一驱动构件和第二驱动构件的诸如位置和尺寸的参数，可以精确地和定量地控制背衬构件的旋转角度或范围。

公开(公告)号：US06955042B1

公开(公告)日：2005-10-18

申请号：US10883069

申请日：2004-06-30

申请人： Wayne G. Wnuck ,  Ke Liu

发明人： Wayne G. Wnuck ,  Ke Liu

IPC分类号： F01N3/00 ,  F01N3/035 ,  F01N3/08 ,  F01N3/36 ,  F01N13/02 ,  F01N13/04

CPC分类号： F01N3/0842 ,  F01N3/035 ,  F01N3/0814 ,  F01N3/0821 ,  F01N3/0871 ,  F01N3/0878 ,  F01N3/36 ,  F01N13/009 ,  F01N13/017 ,  F01N2240/16 ,  F01N2240/20 ,  F01N2240/30 ,  F01N2250/02 ,  F01N2250/12 ,  F01N2250/14 ,  F01N2330/06 ,  F01N2410/00 ,  F01N2410/04 ,  F01N2570/14 ,  F01N2610/1453 ,  Y02A50/2344 ,  Y02T10/24

摘要： A single lean NOx trap (8) has an inlet manifold (10) with baffles (18–20) to divide the inlet manifold into three flow paths (11–13). Each flow path has a thermal reformer (24–26; CPO, (POX, or ATR) with an electric heater provided electric power by related lines (29–31). Fuel from a source (50) is controlled (45–46) to apply pulses of fuel through nozzles (40–42) into each corresponding path (11–13) in turn. A plurality of diesel particulate filters (14) are disposed in the flow paths (11–13) upstream of the lean NOx trap (8). A diesel oxidation catalyst (53) is disposed downstream of the lean NOx trap.

摘要翻译： 单个贫NOx捕集器（8）具有带有挡板（18-20）的入口歧管（10），以将入口歧管分成三个流动路径（11-13）。 每个流路具有热重整器（24-26; CPO，（POX或ATR），电加热器通过相关线路提供电力（29-31），来自源（50）的燃料被控制（45-46） 依次通过喷嘴（40-42）将燃料的脉冲施加到每个对应的路径（11-13）中。多个柴油机微粒过滤器（14）设置在贫NOx捕集器上游的流路（11-13） （8），柴油氧化催化剂（53）设置在贫NOx捕集器的下游。