中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

101 records (took 0.026 seconds)

    Flame ionization detection for supercritical fluid chromatography employing a matched separation column and flame burner
    53.
    发明授权
    Flame ionization detection for supercritical fluid chromatography employing a matched separation column and flame burner 有权

    公开(公告)号：US09664654B2

    公开(公告)日：2017-05-30

    申请号：US14675865

    申请日：2015-04-01

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

    IPC: G01N30/68

    CPC classification number: G01N30/68

    Abstract: The present disclosure relates to flame based detection methods for compressed mobile phase chromatography. In particular, the present disclosure relates to the operation of a flame ionization detector for carbon dioxide based chromatography, such as supercritical fluid chromatography. The present disclosure includes a method of matching a chromatographic column with a flame ionization detector inner burner including providing a chromatographic column with an internal diameter, determining an optimal mobile phase flow rate for the chromatographic column, calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance, and providing a flame ionization detector inner burner having an inner diameter substantially equal to the calculated optimal inner diameter.

    THERMALLY MODULATED VARIABLE RESTRICTOR
    54.
    发明申请
    THERMALLY MODULATED VARIABLE RESTRICTOR 审中-公开
    热调制变量限制器

    公开(公告)号：US20160018366A1

    公开(公告)日：2016-01-21

    申请号：US14773780

    申请日：2014-01-27

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

    IPC: G01N30/30 ,  G01N30/32

    CPC classification number: G01N30/30 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N30/6004 ,  G01N2030/3038 ,  G01N2030/324 ,  G01N2030/6008

    Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

    Abstract translation: 色谱系统中使用的热调制可变限制器可独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 限流器包括具有流体通道的限流器主体，其具有从柱接收流动相的入口和流动相离开流体通道的出口。 设置在流体通道出口附近的限制器尖端具有小于流体通道的内径的出口开口。 热连接到流体通道在其入口和出口之间的子部分的加热元件加热通过流体通道的该部分的流动相。 限制器尖端响应于流动相的加热而产生的限制使得能够独立地控制柱内的流动相的系统压力和线性速度。

    SYSTEMS, DEVICES, AND METHODS FOR CONNECTING A CHROMATOGRAPHY SYSTEM TO A MASS SPECTROMETER
    55.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR CONNECTING A CHROMATOGRAPHY SYSTEM TO A MASS SPECTROMETER 审中-公开
    用于将色谱系统连接到质谱仪的系统，设备和方法

    公开(公告)号：US20150144782A1

    公开(公告)日：2015-05-28

    申请号：US14552872

    申请日：2014-11-25

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff C. Gerhardt

    IPC: H01J49/10 ,  H01J49/00 ,  H01J49/26 ,  H01J49/04

    CPC classification number: H01J49/10 ,  H01J49/0431 ,  Y10T29/5313

    Abstract: The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume.

    Abstract translation: 本发明提供分析仪器之间的界面，例如在色谱系统和质谱仪之间。 在一个示例性实施例中，提供离子源用于将基于二氧化碳的色谱装置连接到质谱仪。 离子源包括用于从色谱装置接收洗脱液的第一管道，用于加热所述第一管道的至少一部分的加热器，与第一管道流体连通的第二管道，用于从所述第二管道接收洗脱液并引入 所述洗脱液进入离子源区域以在所述离子源区域中形成气体和/或液体的羽流;以及电离促进入口，用于将离子化促进流体注入到所述离子源区域中以与所述羽流相互作用以促进至少 一些羽流。

    INSERTION SEALING DEVICE FOR A CHROMATOGRAPHY COLUMN
    57.
    发明申请
    INSERTION SEALING DEVICE FOR A CHROMATOGRAPHY COLUMN 有权

    公开(公告)号：US20240393299A1

    公开(公告)日：2024-11-28

    申请号：US18669944

    申请日：2024-05-21

    Applicant: Waters Technologies Corporation

    Inventor： Michael Scanlon ,  Joseph D. Michienzi ,  Wade P. Leveille

    IPC: G01N30/60 ,  B01D15/22

    Abstract: A device for sealing to a chromatographic column includes an insertion body and a tip assembly. The insertion body has an attachment end, a tip opposite to the attachment end and a fluidic channel extending between the attachment end and the tip. An attachment feature located near the attachment end secures the insertion body to an actuator. An axially movable sheath may be provided at the tip to protect the tip assembly prior to and during coupling to a column end nut and to assist in aligning the device to the column end nut. The device can be loaded by manual clamping or by an automated clamp mechanism to achieve sufficient force for a fluid tight seal in the column end nut. Devices are column agnostic and may be used in a column oven to enable a chromatography system to be quickly configured with a wide variety of columns.

    Dual mode sample manager
    58.
    发明授权
    Dual mode sample manager 有权

    公开(公告)号：US11573210B2

    公开(公告)日：2023-02-07

    申请号：US16826667

    申请日：2020-03-23

    Applicant: Waters Technologies Corporation

    Inventor： Sylvain Gilles Cormier ,  Joseph D. Michienzi

    IPC: G01N30/20 ,  G01N30/32 ,  G01N30/38 ,  G01N30/02

    Abstract: Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

Patent Agency Ranking