Assays which screen for compounds that modulate bitter taste of chlorogenic lactone compounds
    51.
    发明授权
    Assays which screen for compounds that modulate bitter taste of chlorogenic lactone compounds 有权
    测定调节绿色内酯化合物苦味的化合物的筛选

    公开(公告)号:US07939276B2

    公开(公告)日:2011-05-10

    申请号:US11455693

    申请日:2006-06-20

    IPC分类号: G01N33/567 C07K14/705

    摘要: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.

    摘要翻译: 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现,即,至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。 本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品,饮料和药物中去除的配体的用途,以便 修改(阻断)T2R相关的苦味。 优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品,饮料和药物中的添加剂。

    Chimeric human sweet-umami and umami-sweet taste receptors
    52.
    发明授权
    Chimeric human sweet-umami and umami-sweet taste receptors 有权
    嵌合人类甜味和鲜味甜味受体

    公开(公告)号:US07906627B2

    公开(公告)日:2011-03-15

    申请号:US11583097

    申请日:2006-10-19

    摘要: This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.

    摘要翻译: 本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器,以及T1R1或其变体或片段的跨膜部分,T1R1或T1R2,优选与T1R3相关 多肽和合适的G蛋白。 这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。 此外,这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置,并阐明受体活化的机制。

    Method about protecting high layer service in the multilayer communication equipment
    53.
    发明授权
    Method about protecting high layer service in the multilayer communication equipment 有权
    在多层通信设备中保护高层服务的方法

    公开(公告)号:US07881186B2

    公开(公告)日:2011-02-01

    申请号:US10522057

    申请日:2003-07-17

    IPC分类号: H04L1/00

    CPC分类号: H04L12/437

    摘要: This invention relates to a method for protecting high layer service in the multi-layer communication equipment, include that low layer processing module which provides low layer transmission passages for high layer processing module, and high layer processing module which sets up transparent VP link passage from up and down node by the service of said module, in order to make the service processed by the said module avoid influence. Once detecting the fault of the said processing module, high layer processing module will message the low layer processing module, and the low layer processing module will set up bypass connection after detecting the fault of the high layer processing module, then isolate the failed high layer process module. According to the present invention, extra network passages are not necessary, the means of protecting network is not limited. The present invention aims to protect effectively ATM traffic when the processing ability of ATM layer invalidate between MSPP and MSTP. The present invention solves the problem that will influence the other node of the network beyond the said node service in the case of device maintenance.

    摘要翻译: 本发明涉及一种用于保护多层通信设备中的高层业务的方法,包括为高层处理模块提供低层传输通道的低层处理模块,以及建立透明VP链路通道的高层处理模块 通过所述模块的服务来上下节点,以使由所述模块处理的服务避免影响。 一旦检测到所述处理模块的故障,高层处理模块就会通知低层处理模块,低层处理模块将在检测到高层处理模块的故障后建立旁路连接,然后隔离故障高层 过程模块。 根据本发明,不需要额外的网络通道,保护网络的方式不受限制。 本发明旨在在ATM层的处理能力在MSPP与MSTP之间无效时有效保护ATM流量。 在设备维护的情况下,本发明解决了影响网络的其他节点超出所述节点业务的问题。

    CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS
    54.
    发明申请
    CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS 有权
    CHIMERIC人类SWEET-UMAMI和UMAMI-SWEET TASTE RECEPTORS

    公开(公告)号:US20100304402A9

    公开(公告)日:2010-12-02

    申请号:US11583097

    申请日:2006-10-19

    摘要: This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.

    摘要翻译: 本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器,以及T1R1或其变体或片段的跨膜部分,T1R1或T1R2,优选与T1R3相关 多肽和合适的G蛋白。 这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。 此外,这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置,并阐明受体活化的机制。

    System and method of delaying connection acceptance to support connection request processing at layer-7
    55.
    发明授权
    System and method of delaying connection acceptance to support connection request processing at layer-7 有权
    延迟连接验收的系统和方法,以支持第7层的连接请求处理

    公开(公告)号:US07743160B2

    公开(公告)日:2010-06-22

    申请号:US11780432

    申请日:2007-07-19

    IPC分类号: G06F15/16

    摘要: Techniques for suspending a TCP three-way handshake, offering the partial connection to an L-7 application or module at a proxy to perform further processing, and then allowing the L-7 application or module to instruct the proxy's network kernel to perform various actions are described. In various embodiments these actions may include: silently dropping the connection, verbosely rejecting the connection, accepting and processing the connection locally, or forwarding the connection to another proxy or the original destination. This additional functionality is provided, in one particular embodiment, via extensions to the POSIX socket API.

    摘要翻译: 用于暂停TCP三次握手的技术,向代理处的L-7应用或模块提供部分连接以执行进一步处理,然后允许L-7应用或模块指示代理的网络内核执行各种动作 被描述。 在各种实施例中,这些动作可以包括:静默地丢弃连接,详细地拒绝连接,本地接受和处理连接,或将连接转发到另一代理或原始目的地。 在一个特定实施例中,通过对POSIX套接字API的扩展来提供该附加功能。

    Slice-Based Prioritized Secure Video Streaming
    56.
    发明申请
    Slice-Based Prioritized Secure Video Streaming 有权
    基于片的优先安全视频流

    公开(公告)号:US20100002875A1

    公开(公告)日:2010-01-07

    申请号:US12140085

    申请日:2008-06-16

    申请人: Qing Li

    发明人: Qing Li

    IPC分类号: H04L9/18 H04L9/28 H04L9/08

    摘要: Slice-based prioritized secure video streaming comprises a transmitter receiving a slice comprising a plurality of macroblocks and selecting an encryption key based at least in part on a relative importance of secure transmission of the macroblocks. If the importance is high, a master key is selected. If the importance is medium, a first key derivable by applying a one-way function to the master key is selected. If the importance is low, a second key derivable by applying the one-way function to the first key is selected. The slice is encrypted using the encryption key. A receiver receives the encrypted slice, decrypts a header of the slice using the master key, to obtain an indication of a relative importance of secure transmission of the macroblocks. The receiver selects a decryption key based at least in part on the indication, and decrypts the slice using the decryption key.

    摘要翻译: 基于片段的优先安全视频流包括发射机,其接收包括多个宏块的切片,并且至少部分地基于宏块的安全传输的相对重要性来选择加密密钥。 如果重要性很高,则选择主密钥。 如果重要性是中等的,则选择通过对主密钥应用单向函数而导出的第一密钥。 如果重要性低,则选择通过将单向函数应用于第一密钥而导出的第二密钥。 使用加密密钥对切片进行加密。 接收器接收加密的片,使用主密钥解密片的头,以获得宏块的安全传输的相对重要性的指示。 所述接收机至少部分地基于所述指示来选择解密密钥,并且使用所述解密密钥来解密所述切片。

    Determining a power control group boundary of a power control group
    59.
    发明授权
    Determining a power control group boundary of a power control group 有权
    确定功率控制组的功率控制组边界

    公开(公告)号:US07558591B2

    公开(公告)日:2009-07-07

    申请号:US10963046

    申请日:2004-10-12

    IPC分类号: H04B7/00 H04Q7/20

    CPC分类号: H04W52/54

    摘要: Determining a power control group boundary includes receiving a plurality of samples having power control groups, where each power control group corresponds to a time period. The following are repeated for a predetermined number of iterations: a window is set at a point of a sample; a number of power control bits within the window at the point is determined; and the window is moved to a point of a next sample. A point at which the window has the largest number of power control bits is identified. A power control group boundary is determined in accordance with the window at the identified point.

    摘要翻译: 确定功率控制组边界包括接收具有功率控制组的多个样本,其中每个功率控制组对应于时间段。 对于预定次数的迭代重复以下操作:在样本点设置窗口; 确定该点内窗口内的多个功率控制位; 并将窗口移动到下一个样本的点。 识别窗口具有最大数量的功率控制位的点。 根据识别点处的窗口确定功率控制组边界。