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51.发明申请公开(公告)号：US20180305722A1
公开(公告)日：2018-10-25
申请号：US15763323
申请日：2016-09-15
Applicant: KANEKA CORPORATION
Inventor： Shingo KOBAYASHI , Hitoshi SASHIWA , Tetsuya FUJIKI
Abstract: An object of the invention is to improve the crystallization speed of a PHA copolymer which is to be slowly crystallized, and improve the melt workability and productivity. A microorganism is used which has genes encoding two or more different PHA synthases derived from the genus Aeromonas. The genes encoding the PHA synthases derived from the genus Aeromonas preferably include genes encoding at least two PHA synthases which are capable of synthesizing a copolymer PHA including, as monomer unit species, 3-hydroxybutyric acid and 3-hydroxyhexanoic acid, and which are different in substrate specificity toward 3-hydroxyhexanoic acid from each other. When this microorganism is cultured, a PHA mixture can be produced which includes three or more PHA species different in melting point from each other.
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公开(公告)号：US20180273993A1
公开(公告)日：2018-09-27
申请号：US15765148
申请日：2016-09-30
Applicant: API CORPORATION
Inventor： Ryoma MIYAKE , Hiroshi KAWABATA
IPC: C12P17/12
CPC classification number: C12P17/12 , C12N9/0016 , C12N9/0022 , C12N9/0071 , C12N9/1096 , C12N15/09 , C12Y114/11028
Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.
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公开(公告)号：US20180265878A1
公开(公告)日：2018-09-20
申请号：US15710849
申请日：2017-09-21
Applicant: NATIONAL TSING HUA UNIVERSITY , Chang Chun Plastics Co., Ltd. , Chang Chun Petrochemical Co., LTD.
Inventor： Yuan YAO , Bo-Fan HSEUH
CPC classification number: C12N15/70 , B01D3/4211 , C07H17/08 , C12N15/09 , C12Q1/18 , C12R1/465 , G01N30/52 , G01N30/8658 , G01N2030/889
Abstract: A method of real-time prognosis of a flooding phenomenon in a packed column includes steps as follows. An online data collection step is conducted, wherein a plurality of values of the pressure drop are collected from the packed column under operation. A calculation step is conducted, wherein the values of the pressure drop are used to calculate a plurality of values of a steadiness index. A statistical step is conducted, wherein a value of a monitoring statistic is calculated based on the values of the steadiness index. A control step is conducted, wherein the value of the monitoring statistic is compared to a control limit, and an alarm is triggered when the value of the monitoring statistic is greater than the control limit.
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公开(公告)号：US20180265553A1
公开(公告)日：2018-09-20
申请号：US15779106
申请日：2016-11-30
Applicant: IDEMITSU KOSAN CO., LTD.
Inventor： Kazutoshi SAWADA , Takeshi MATSUI
IPC: C07K14/005 , C12N7/00 , C07K14/25 , C07K14/245 , C07K14/28
CPC classification number: C07K14/005 , A01H5/00 , A23K20/195 , A61K36/28 , A61K39/00 , C07K14/245 , C07K14/25 , C07K14/28 , C07K14/405 , C07K19/00 , C07K2319/55 , C12N7/00 , C12N15/09 , C12N2750/14322
Abstract: According to the invention, immunogenicity of an antigenic peptide is increased by administering a fusion protein, which comprises an antigenic peptide and an adjuvant protein, wherein the adjuvant protein comprises two or more proteins selected from the group consisting of a Shiga toxin 2e B subunit (Stx2eB), an Escherichia coli heat-labile toxin B subunit (LTB), and a cholera toxin B subunit (CTB). or a transformant transformed by a gene coding for the fusion protein.
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公开(公告)号：US10077297B2
公开(公告)日：2018-09-18
申请号：US15552065
申请日：2016-02-19
Applicant: Kissei Pharmaceutical Co., Ltd.
Inventor： Takashi Sakamoto , Yoichi Inada , Kazumasa Yokoyama
IPC: A61K39/00 , C07K14/735
CPC classification number: C07K14/70535 , A61K38/16 , C07K14/705 , C07K16/18 , C07K19/00 , C07K2319/30 , C12N15/09
Abstract: Provided is an Fc fusion high affinity IgE receptor α-chain having excellent stability at low pH.An Fc fusion protein comprising: (i) a high affinity IgE receptor α-chain; and (ii) an Fc region of IgG1, wherein a linker fragment region between the (i) and the (ii) is the amino acid sequence shown in SEQ ID NO: 2.
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Patent Agency Ranking
公开(公告)号：US20180251850A1
公开(公告)日：2018-09-06
申请号：US15753994
申请日：2016-08-23
Applicant: Astellas Pharma Inc. , National Cancer Center
Inventor： Hiroki Sasaki , Hitoshi Ichikawa
IPC: C12Q1/6886 , C12Q1/6853 , C12Q1/686
CPC classification number: C12Q1/6886 , C12N15/09 , C12Q1/68 , C12Q1/6853 , C12Q1/686 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an RP2 gene and a part of an ARHGAP6 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding RP2 and an antisense primer designed from a section encoding ARHGAP6.
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公开(公告)号：US20180237862A1
公开(公告)日：2018-08-23
申请号：US15753775
申请日：2016-08-23
Applicant: Astellas Pharma Inc. , National Cancer Center
Inventor： Hiroki Sasaki , Hitoshi Ichikawa , Makoto Asaumi , Kazuhisa Tsunoyama
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12N15/09 , C12Q1/68 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an OCLN gene and a part of an ARHGAP26 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding OCLN and an antisense primer designed from a section encoding ARHGAP26.
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公开(公告)号：US20180237803A1
公开(公告)日：2018-08-23
申请号：US15532826
申请日：2014-12-05
Applicant: HONDA MOTOR CO., LTD.
Inventor： Yoshiki Tsuchida , Norihiko Tsukagoshi , Ikumi Kurihara , Akihiko Aoyagi
Abstract: An object of the present invention is to obtain fermentative yeast having highly efficient ethanol production without introducing a foreign gene. A further object is to obtain a fermentative yeast that is resistant to proliferation inhibitors such as organic acids, which prevent the proliferation of the fermentative yeast. Meyerozyma guilliermondii that can produce ethanol effectively from pentose and hexose was isolated by breeding. Moreover, resistance was imparted to the fermentative yeast by introducing transaldolase and alcohol dehydrogenase genes derived from Meyerozyma guilliermondii into the fermentative yeast.
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公开(公告)号：US20180230205A1
公开(公告)日：2018-08-16
申请号：US15870532
申请日：2018-01-12
Inventor： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
IPC: C07K16/18 , A61K47/68 , C07K16/30 , G01N33/574 , G01N33/577 , C12N15/86 , C12N15/09 , C12N5/10 , C12N15/82 , C12N15/62 , A61K39/00
CPC classification number: C07K16/18 , A61K39/00 , A61K47/6843 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K16/3092 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/10 , C12N15/09 , C12N15/62 , C12N15/8258 , C12N15/86 , C12N2800/00 , C12N2810/859 , G01N33/574 , G01N33/577 , G01N2333/47 , G01N2333/4727 , G01N2800/7028
Abstract: Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.
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公开(公告)号：US20180228830A1
公开(公告)日：2018-08-16
申请号：US15749831
申请日：2016-10-21
Applicant: RENA THERAPEUTICS INC.
Inventor： Junichi YANO , Kazuaki TANIGAWARA , Takanori YOKOTA , Kotaro YOSHIOKA
IPC: A61K31/7105 , C12N15/113 , A61K47/26
CPC classification number: A61K31/7105 , A61K31/20 , A61K31/223 , A61K31/355 , A61K31/519 , A61K31/713 , A61K47/26 , A61K48/0075 , C12N15/09 , C12N15/113 , C12N2310/11 , C12N2310/313 , C12N2310/321 , C12N2310/3231 , C12N2310/35 , C12N2310/50
Abstract: [Problem to be Solved ] Provided is a nucleic acid complex, preferably a double-stranded nucleic acid complex, having an excellent effect of suppressing the expression of a target gene.[Solution] The problem is solved by using a nucleic acid complex, preferably a double-stranded nucleic acid complex, comprising an active moiety comprising an antisense nucleic acid complementary to a transcript, for example, a transcript of a target gene, and a carrier moiety comprising a nucleic acid complementary to the nucleic acid, and having at least one bulge structure.[Selected Drawing] None
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