公开(公告)号：US11920152B2

公开(公告)日：2024-03-05

申请号：US17099503

申请日：2020-11-16

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  James Angstman ,  Shengdar Tsai

IPC: C07H21/02 ,  C07K14/005 ,  C07K14/195 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N15/90

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12Y301/21004 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：US11905535B2

公开(公告)日：2024-02-20

申请号：US17812826

申请日：2022-07-15

Applicant: EMPYREAN NEUROSCIENCE, INC.

Inventor： Thomas Henley ,  Modassir Choudhry ,  Jose Fernandez-Gomez

IPC: C12N9/02 ,  A61K36/07 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88

CPC classification number: C12N9/0083 ,  A61K36/07 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/88 ,  C12Y114/99 ,  C12Y201/01 ,  C12Y207/01 ,  C12Y401/01

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

公开(公告)号：US20230372454A1

公开(公告)日：2023-11-23

申请号：US18248648

申请日：2021-10-12

Applicant: ANIMUSCURE INC.

Inventor： Jong Sun KANG ,  Hye Been KIM ,  Su Bin AN

IPC: A61K38/45 ,  A61P21/00 ,  G01N33/50

CPC classification number: A61K38/45 ,  C12Y201/01 ,  A61P21/00 ,  G01N33/5058 ,  G01N2333/91011

Abstract: The present invention relates to a use for, by using the protein arginine methyltransferase 1 (PRMT1) protein or a gene encoding the same, preventing or treating a neuromuscular disease induced by motor neurons, particularly, damage to motor neurons caused by oxidative stress in the neuromuscular junction; and a method for screening a candidate material for activating the expression of PRMT1. PRMT1 deficiency in the motor nerve or neuromuscular junction induces aggravated degenerative motor nerve damage caused by aging, and DNA damage caused by oxidative stress and inflammation, thereby enabling the induction of neuromuscular disease, and thus the disease may be treated through the overexpression and activity of the PRMT1 protein and a gene encoding the same.

公开(公告)号：US20230220357A1

公开(公告)日：2023-07-13

申请号：US17765692

申请日：2020-09-25

Applicant: Suntory Holdings Limited

Inventor： Noriko Nakamura ,  Naoko Okitsu ,  Yukihisa Katsumoto

IPC: C12N9/10 ,  C12N9/02 ,  C12N9/88 ,  C12N15/82 ,  A01H6/74 ,  A01H5/02

CPC classification number: C12N9/1051 ,  C12N9/0071 ,  C12N9/88 ,  C12N9/1007 ,  C12Y204/01 ,  C12Y114/14 ,  C12Y402/01105 ,  C12Y201/01 ,  C12N15/825 ,  A01H6/749 ,  A01H5/02

Abstract: Transgenic plants with blue flower color, or their inbred or outbred progeny, or their propagules, partial plant bodies, tissues or cells, are provided. A buckwheat-derived C-glucosyltransferase (CGT) gene or its homolog is transferred into a host plant to cause delphinidin-type anthocyanins and flavone mono-C-glycosides to be copresent in the plant cells.

公开(公告)号：US20190194707A1

公开(公告)日：2019-06-27

申请号：US15764644

申请日：2016-09-30

Applicant: SYMRISE AG ,  LEIBNITZ-INSTITUT FUER PFLANZENBIOCHEMIE

Inventor： Ludger A. WESSJOHANN ,  Susann HERRMANN ,  Martin DIPPE ,  Torsten GEISSLER ,  Katrin GEISSLER ,  Jakob Peter LEY

IPC: C12P17/06 ,  C12P7/42 ,  C12P7/22 ,  C12P17/10 ,  C12P7/26 ,  C12N9/10 ,  C12N9/02

CPC classification number: C12P17/06 ,  C12N9/0071 ,  C12N9/1007 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12P17/10 ,  C12Y114/14001 ,  C12Y201/01

Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.

公开(公告)号：US20180208921A1

公开(公告)日：2018-07-26

申请号：US15870659

申请日：2018-01-12

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  James Angstman ,  Jeffry D. Sander ,  Morgan Maeder ,  Shengdar Tsai

IPC: C12N15/10 ,  C07K14/005 ,  C12N9/22 ,  C12N9/96 ,  C12N15/85 ,  C12N9/02 ,  C12N15/63 ,  C12N9/16 ,  C07K14/195 ,  C12N9/10 ,  C12N15/01

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：US20180179561A1

公开(公告)日：2018-06-28

申请号：US15737021

申请日：2016-06-22

Applicant: Serturner Corp.

Inventor： Peter James Facchini ,  Jillian Hagel

IPC: C12P13/00

CPC classification number: C12P13/001 ,  C07C213/08 ,  C12N9/1007 ,  C12Y201/01 ,  C07C215/30

Abstract: Methods for making alkaloid compounds, including ephedrine and derivatives thereof. The methods involve the performance of an N-methyltransferase catalyzed chemical reaction.

公开(公告)号：US09885033B2

公开(公告)日：2018-02-06

申请号：US14776620

申请日：2014-03-14

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  James Angstman ,  Jeffry D. Sander ,  Morgan Maeder ,  Shengdar Tsai

IPC: C07H21/02 ,  C12N15/00 ,  A61K48/00 ,  C12N15/10 ,  C12N9/22 ,  C12N15/63 ,  C12N15/85 ,  C07K14/005 ,  C07K14/195 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/96 ,  C12N15/01

CPC classification number: C12N15/102 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：US20180010132A1

公开(公告)日：2018-01-11

申请号：US15510542

申请日：2015-09-09

Applicant: NOVARTIS AG

Inventor： Konstantinos John MAVRAKIS ,  Earl Robert MCDONALD, III ,  Frank Peter STEGMEIER

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/7088 ,  C07K16/40 ,  A61K39/395 ,  G01N33/574 ,  A61K39/00

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/10 ,  C12N2320/31 ,  C12Y201/01 ,  G01N33/574 ,  G01N33/57496 ,  G01N2800/52

Abstract: The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is MTAP-deficient and/or MTA-accumulating and thus amenable to therapeutic treatment with a PRMT5 inhibitor. Kits, methods of screening for candidate PRMT5 inhibitors, and associated methods of treatment are also provided.

公开(公告)号：US20170152508A1

公开(公告)日：2017-06-01

申请号：US15430218

申请日：2017-02-10

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  Jeffry D. Sander ,  Morgan Maeder ,  Yanfang Fu

IPC: C12N15/10 ,  C12N15/85

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).